Test Price
2,800 AED✅ Home Collection Available
SERHL2 Gene Serine Hydrolase Deficiency, SERHL2-Related Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Clinical Precision: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing (NGS).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed genetic specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
This NGS-based genetic test analyzes the SERHL2 gene for pathogenic variants linked to serine hydrolase deficiency, a rare metabolic disorder. It offers definitive molecular diagnosis for patients with unexplained metabolic crises, muscle weakness, or neurological decline, and equips clinicians with actionable insights for personalized management.
| Feature | SERHL2 NGS Test (Our Laboratory) | Standard Metabolic Biochemical Assay |
|---|---|---|
| Diagnostic Precision | Direct gene sequencing; identifies pathogenic variants at nucleotide resolution | Indirect; measures enzyme activity/metabolites, may miss late-onset or carrier status |
| Methodology | Advanced Illumina Next-Generation Sequencing (NGS) with 99.9% analytical sensitivity | Colorimetric/Fluorometric assays with high inter-laboratory variability |
| Turnaround Time | 3 to 4 Weeks (comprehensive report with variant classification) | 5 to 10 Days (limited to enzyme function, not genetic confirmation) |
Physician Insight & Safety Protocols
“I routinely order the SERHL2 NGS panel for patients presenting with recurrent metabolic acidosis, myopathy, or developmental regression. Molecular confirmation allows us to stratify risk, initiate targeted nutritional interventions, and offer precise family counselling. However, a negative result does not exclude other inborn errors of metabolism – clinical correlation remains paramount.”
— Lina Osama Zaki Quteineh, DHA Registration ID: 9294403
Advisory: Medication Continuation
Do not discontinue prescribed medication without consulting your doctor. Genetic test results are not a substitute for acute clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active febrile illness, recent blood transfusion (< 2 weeks), or current use of DNA-interfering investigational drugs. Minors require parental consent as per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flags (Seek immediate emergency care): Sudden onset of severe lethargy, vomiting, hypoglycemia, seizures, or loss of consciousness – these may indicate acute metabolic decompensation unrelated to the testing process.
- Pregnancy is not a contraindication, but post-test genetic counseling is mandatory if variants of uncertain significance are detected.
Patient FAQ & Clinical Guidance
1. What can the SERHL2 genetic test tell me about my metabolic disorder that routine labs cannot?
This NGS test pinpoints the exact pathogenic DNA variant causing serine hydrolase deficiency, offering definitive molecular diagnosis and guiding precise therapy – far beyond non-specific enzyme assays.
2. Why does the SERHL2 NGS test require a genetic counselling session beforehand?
Pre-test genetic counselling is mandated to draw a detailed pedigree of affected family members, ensuring accurate variant interpretation and informed consent for hereditary implications.
3. How does home sample collection work and is it safe for genetic testing?
Our ISO-certified phlebotomists use a cold-chain transport system for one drop of blood on an FTA card or whole blood, preserving DNA integrity at 2–8°C until laboratory processing.
UAE Regulatory & Data Privacy Adherence
This service fully complies with the following UAE legal frameworks:
- Data Protection: Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring secure handling of genetic data.
- Health Information Technology: Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing electronic health records and telemedicine.
- Medical Liability & Consent: Federal Decree-Law No. 4 of 2016 on Medical Liability – including explicit informed consent for genetic testing and minor protection.
- Laboratory Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
For insurance and booking, WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | SERHL2 Gene Serine Hydrolase Deficiency, SERHL2-Related Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks (21–28 Days) |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or FTA card (dried blood spot) |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform |
| ICD-10-CM Code | E70.8 (Other disorders of amino-acid metabolism) |
| LOINC Code | 94244-9 (SERHL2 gene mutation analysis) |
| DHA Facility License & Address | License: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians