Test Price
2,800 AED✅ Home Collection Available
ABCB11 Gene Progressive Intrahepatic Cholestasis Type 2 (PFIC2) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next‑Generation Sequencing (NGS) for full ABCB11 gene analysis.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post‑test result interpretation by a Consultant Medical Genetics specialist.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing test comprehensively analyzes the entire coding region of the ABCB11 gene to diagnose progressive familial intrahepatic cholestasis type 2 (PFIC2) with 99.9% diagnostic sensitivity. A mandatory pre‑test genetic counselling session and pedigree chart are included to ensure informed decision‑making and accurate familial risk assessment.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Technology | Full Gene Next‑Generation Sequencing (NGS) | Targeted Mutation Panel / Biochemical Assays |
| Sensitivity | 99.9% | 70–85% (limited to known mutations) |
| Turnaround Time | 3–4 Weeks | Variable (often 6–8 weeks for send‑out) |
| Pre‑Test Genetic Counselling | Included (Mandatory Pedigree Charting) | Often not included |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that this NGS panel provides definitive molecular diagnosis for PFIC2. However, results must always be correlated with clinical symptoms, bile acid profiles, and liver biopsy when indicated. Genetic counselling is essential for understanding autosomal recessive inheritance and planning cascade testing for at‑risk family members. Never base treatment decisions solely on genetic findings without comprehensive specialist consultation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Mandatory Pre‑Test Genetic Counselling
A mandatory pre‑test genetic counselling session with pedigree charting is required before blood draw. This ensures the patient understands the implications of results, including recurrence risks and family screening options. The session is conducted by a qualified genetic counsellor and is included in the test price.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Recent blood transfusion (<2 weeks), inability to provide informed consent for genetic testing, active acute illness that may interfere with phlebotomy.
- Emergency Red Flags – Seek Immediate Medical Attention: Rapid onset of severe jaundice with coagulopathy, hepatic encephalopathy (confusion, asterixis), or intractable pruritus unresponsive to standard therapy.
Patient FAQ & Clinical Guidance
1. What is the ABCB11 gene test and why is it performed?
The ABCB11 gene test is a next‑generation sequencing‑based analysis that identifies mutations causing progressive familial intrahepatic cholestasis type 2 (PFIC2). It is recommended for patients with unexplained cholestasis, elevated bile acids, or a family history of PFIC syndromes. A positive result guides targeted therapy with ileal bile acid transporter inhibitors, surgical biliary diversion, or early liver transplant evaluation.
2. How is the sample collected and what is the turnaround time?
A small peripheral whole blood sample is collected via VIP Mobile Phlebotomy at your home or in our clinic. Results are delivered within 3 to 4 weeks using advanced sequencing technology. Our temperature‑controlled cold‑chain logistics ensure sample stability from collection to the ISO 9001:2015‑accredited laboratory. Mandatory genetic counselling is conducted before the blood draw.
3. What does a positive result indicate for the patient and family?
A positive result confirms a molecular diagnosis of PFIC2, enabling targeted treatment planning including specialized bile acid therapy, liver transplant evaluation, and family planning. Because PFIC2 follows autosomal recessive inheritance, cascade testing for at‑risk relatives is recommended. Genetic counselling can estimate recurrence risk for future pregnancies. Always discuss results with your hepatologist or clinical geneticist.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, anonymized, and stored on secure UAE‑based servers. Clinical testing safety and patient consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. Your privacy and data security are our highest priority.
Clinical & Logistical Metadata
| Test Name | ABCB11 Gene Progressive Intrahepatic Cholestasis Type 2 (PFIC2) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Full Gene Next‑Generation Sequencing (NGS) |
| ICD‑10‑CM Code | K76.8 |
| LOINC Code | 21629-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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