Test Price
2,800 AED✅ Home Collection Available
ICOS Gene Common Variable Immunodeficiency Type 1 (CVID1) Next‑Generation Sequencing – Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical & Patient Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post‑Test Genetic Counselling for result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS panel targets the full coding region of the ICOS gene to diagnose common variable immunodeficiency type 1 (CVID1), an inherited primary immunodeficiency. The assay detects single‑nucleotide variants, small insertions/deletions, and copy‑number alterations with analytical sensitivity >99.9%. Early identification allows tailored immunoglobulin replacement therapy, infection prophylaxis, and informed genetic counselling.
| Feature | Our NGS Test | Closest Alternative (Sanger Seq.) |
|---|---|---|
| Precision | >99.9% analytical sensitivity & specificity for single‑nucleotide, indel & copy‑number variants | ~99% accuracy for known single‑site variants; low sensitivity for novel/large rearrangements |
| Methodology | Targeted NGS (Next‑Generation Sequencing) with ACMG/AMP‑compliant variant interpretation | Sanger sequencing of specific exons or a known familial mutation |
| Turnaround Time | 3–4 Weeks (expedited options available) | 2–4 Weeks, but limited to single‑variant analysis |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist (DHA License 9294403), I emphasise that a germline variant in ICOS is one piece of the immunological puzzle – it must always be correlated with quantitative immunoglobulins, lymphocyte subsets, and a detailed infection history. A positive result alone does not establish a diagnosis; it mandates a referral to a clinical immunologist. Please do not modify any prescribed immunoglobulin, antibiotic, or immunosuppressive therapy without your specialist’s explicit guidance.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics
Advisory & Medication Caution
⚠️ Important Medication Warning
Do not discontinue prescribed medication (e.g., immunoglobulin replacement, antibiotics, corticosteroids) without consulting your treating physician. Abrupt cessation of immunosuppressive or replacement therapy can trigger severe infections or autoimmune crises.
Safety & Exclusion Criteria
- Exclusion criteria: Severe coagulopathy, active systemic infection with haemodynamic instability, or inability to provide a minimum volume of blood/DNA specimen.
- FTA card collection: May be refused if the sample appears compromised or insufficient; a repeat venipuncture may be required.
- Emergency red flags – seek immediate medical attention: Signs of a severe infection (high fever, rigors, difficulty breathing), acute autoimmune flare (e.g., haemolytic crisis, pneumonitis), or anaphylaxis after any test‑related procedure.
- Paediatric consent: In compliance with UAE Federal Law No. 2 of 2019, a legal guardian’s written consent is mandatory for individuals under 18 years.
Patient FAQ & Clinical Guidance
1. What does the ICOS gene test detect, and why is it ordered?
This test analyzes the ICOS gene for pathogenic variants linked to common variable immunodeficiency type 1 (CVID1). It helps confirm a suspected diagnosis, guide immunoglobulin replacement decisions, and facilitate carrier testing among at‑risk family members.
2. How is the sample collected, and what preparation is required?
A hospital‑grade home phlebotomist collects a peripheral blood sample under strict cold‑chain logistics. A dedicated genetic counselling session is provided beforehand to document family history and obtain informed consent. No special preparation (fasting) is needed.
3. Will insurance cover the 2800 AED cost, and how quickly are results available?
Many UAE insurers cover medically indicated genetic testing; our team verifies eligibility directly via WhatsApp (+971 54 548 8731). Results are delivered within 3–4 weeks, with optional express processing available on request.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- Personal Data Protection: All patient data processed in strict adherence to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Security: Digital infrastructure complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields to ensure confidentiality, integrity and availability of health records.
- Medical Liability: Clinical safety and patient consent follow the provisions of Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ICOS Gene Common Variable Immunodeficiency Type 1 (CVID1) Next‑Generation Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks (expedited options available) |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA), or DNA extracted from blood. FTA cards accepted with pre‑approval. |
| Methodology Used | Targeted Next‑Generation Sequencing (NGS) – Illumina platform, full coding region + splice sites, ACMG/AMP variant interpretation |
| ICD‑10‑CM Code | D83.0 (Common variable immunodeficiency with predominant abnormalities in B‑cell numbers and function) |
| LOINC Code | 101377‑5 (ICOS gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Laboratory: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians