Test Price
2,800 AED✅ Home Collection Available
ICOS Gene Common Variable Immunodeficiency Type 1 (CVID1) Next‑Generation Sequencing (Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين ICOS لعوز المناعة المتغير الشائع من النوع الأول (CVID1) بتقنية التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical & Patient Executive Summary
ملخص تنفيذي: يقدم هذا الفحص الجيني المتقدم تحليلًا شاملاً لجين ICOS للكشف عن الطفرات المسببة لعوز المناعة المتغير الشائع من النوع الأول (CVID1)، بدقة تشخيصية تصل إلى 99.9% عبر معالجة مختبرية معتمدة وفق معيار ISO 9001:2015. تشمل الخدمة جمع العينات المنزلية بسلسلة تبريد معتمدة، واستشارة طبية بعد الفحص، ودعم التأمين الصحي المباشر.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain & VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by a senior genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
This advanced NGS panel targets the full coding region of the ICOS gene to diagnose common variable immunodeficiency type 1 (CVID1), an inherited primary immunodeficiency. يكشف الفحص الطفرات المسببة للمرض ويدعم التشخيص المبكر وتقييم أفراد العائلة المعرضين للخطر.
Early identification allows tailored immunoglobulin replacement therapy, infection prophylaxis, and genetic counselling.
| Feature | Our NGS Test | Closest Alternative (Sanger Seq.) |
|---|---|---|
| Precision | >99.9% analytical sensitivity & specificity for single-nucleotide, indel & copy number variants | ~99% accuracy for known single-site variants; low sensitivity for novel/large rearrangements |
| Methodology | Targeted NGS (Next‑Generation Sequencing) with ACMG/AMP-compliant variant interpretation | Sanger sequencing of specific exons or a known familial mutation |
| Turnaround Time | 3–4 Weeks (expedited options available) | 2–4 Weeks, but limited to single-variant analysis |
Physician Insight & Safety Protocol
“As a board‑certified dermatologist and clinical observer in immunogenetics (DHA license 61713011), I urge every patient and family to understand that a genetic variant in ICOS provides a piece of the puzzle — it must be correlated with immunological work‑up and symptomatic history. A positive result alone does not constitute a diagnosis; it warrants referral to a clinical immunologist. Please do not discontinue prescribed immunoglobulin or prophylactic treatments without your specialist’s explicit guidance.” — Dr. PRABHAKAR REDDY
⚠️ Medication Warning:
Do not discontinue prescribed medication (e.g., immunoglobulin replacement, antibiotics, corticosteroids) without consulting your treating physician. Stopping immunosuppressive or replacement therapy abruptly can trigger severe infections or autoimmune crises.
Safety & Exclusion Criteria
- Exclusion criteria: Severe coagulopathy, active systemic infection with haemodynamic instability, or inability to provide a minimum volume of blood/DNA specimen.
- FTA card collection: May be refused if the sample appears compromised or insufficient; a repeat venipuncture may be required.
- Emergency red flags – seek immediate medical attention: Signs of a severe infection (high fever, rigors, difficulty breathing), acute autoimmune flare (e.g., haemolytic crisis, pneumonitis), or anaphylaxis after any test-related procedure.
- Paediatric consent: In compliance with UAE CDS Law 2026, a legal guardian’s written consent is mandatory for individuals under 18 years.
Patient FAQ & Clinical Guidance
1. What does the ICOS gene test detect, and why is it ordered?
This analyzes the ICOS gene for pathogenic variants linked to common variable immunodeficiency type 1, helping confirm a suspected diagnosis and guide family screening. يكشف التحليل الطفرات المسببة لعوز المناعة المتغير الشائع من النوع الأول ويُستخدم لتأكيد التشخيص وفحص الأقارب.
2. How is the sample collected, and what preparation is required?
A hospital-grade home phlebotomist collects a blood sample (or an accepted DNA/FTA card specimen); a dedicated genetic counselling session beforehand helps draw a detailed pedigree. يتم جمع عينة الدم منزلياً بواسطة أخصائي معتمد، وتُجرى جلسة استشارة وراثية لتوثيق تاريخ العائلة.
3. Will insurance cover the 2800 AED cost, and how quickly are results available?
Many UAE insurers provide coverage for medically indicated genetic testing; our team verifies eligibility directly via WhatsApp, and results are delivered in 3–4 weeks with optional express processing. تغطي كثير من شركات التأمين الفحص إذا كان مبرراً طبياً، ونحن نتحقق من التغطية مباشرة عبر واتساب، وتصدر النتائج خلال 3–4 أسابيع.
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians