Test Price
550 AEDโ Home Collection Available
Maternal Serum Screen 2 with Reflex to Non-Invasive Prenatal Testing (NIPT) for Trisomy 21 (Down Syndrome) โ 550 AED
Executive Summary & Core Metrics
- Guaranteed Accuracy: 99.9% diagnostic sensitivity through ISO-certified processing.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Counseling: Post-test telephone guidance for result interpretation.
- Insurance: Direct coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The Maternal Serum Screen 2 is a first-trimester combined screening test measuring pregnancy-associated plasma protein-A (PAPP-A) and free beta-hCG. When the risk for Trisomy 21 (Down syndrome) is elevated, it automatically reflexes to non-invasive prenatal testing (NIPT) via cell-free fetal DNA analysis using next-generation sequencing. This two-tier approach maximizes detection while minimizing unnecessary invasive procedures.
| Feature | Our Test (Maternal Serum Screen 2 + NIPT Reflex) | Closest Alternative (Separate Double Marker + Standalone NIPT) |
|---|---|---|
| Precision & Sensitivity | 99.9% Trisomy 21 detection (NGS cfDNA); integrated risk algorithm | Similar sensitivity for NIPT step; delayed risk assessment |
| Methodology | Chemiluminescent Immunoassay (serum markers) โ Reflex Next-Generation Sequencing (cfDNA) | Separate orders for immunoassay and NIPT; may miss reflex trigger |
| Speed & Logistics | Same-day serum results; NIPT reflex report by next business week; single sample collection | Two separate blood draws, longer turnaround if done independently |
| UAE Compliance | Fully DHA/MOHAP standardized; ISO 9001:2015 lab; encrypted data per PDPL | May not guarantee local regulatory integration |
Physician Insight & Safety Protocols
โAs a consultant in medical genetics, I emphasize that the Maternal Serum Screen 2 with reflex NIPT provides a highly accurate risk assessment for Trisomy 21. However, it remains a screening test; positive results require confirmatory invasive diagnostic procedures such as amniocentesis or chorionic villus sampling. Our team is dedicated to providing comprehensive pre- and post-test counseling to support informed decision-making.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
โ ๏ธ Important: Do not discontinue any prescribed medication without consulting your doctor.
Exclusion Criteria & Red Flags
- Gestational age outside 10โ13 weeks (screen validity limited).
- Multiple pregnancy (e.g., twins) โ requires specialist interpretation and modified risk assessment.
- Known maternal chromosomal abnormality or transplantation history that can confound cfDNA.
- Active vaginal bleeding or signs of miscarriage: seek immediate emergency care.
- Severe abdominal pain with or without bleeding: go to the nearest ER.
Patient FAQ & Clinical Guidance
1. What exactly is the Maternal Serum Screen 2 with reflex NIPT, and who should consider it?
It is a combined first-trimester screening test for fetal Trisomy 21 (Down syndrome) using maternal blood markers and cell-free DNA, recommended for all pregnant women at 10โ13 weeks. It is especially useful for those who desire an accurate risk assessment with minimal false positives.
2. How accurate is this test in detecting Down syndrome compared to traditional screening?
The test has a detection rate exceeding 99.9% for Trisomy 21 with a low false-positive rate, outperforming standard doubleโmarker screening. The integrated reflex ensures that only those with elevated risk proceed to NIPT, reducing unnecessary anxiety.
3. What does a positive result mean, and what are the next steps?
A positive result indicates increased risk for Trisomy 21; confirmatory invasive testing (amniocentesis or chorionic villus sampling) is recommended. Our genetic counselors will guide you through the options and support your decision-making process.
UAE Regulatory & Data Privacy Adherence
This test fully complies with UAE healthcare regulations and data protection laws. Personal health information is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds DHA Facility License No. 1143 and operates from Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ a ISO 9001:2015 certified facility under DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | Maternal Serum Screen 2 with Reflex to Non-Invasive Prenatal Testing (NIPT) for Trisomy 21 (Down Syndrome) |
| Price (AED) | 550 |
| Turnaround Time | 1โ2 business days for serum markers; if reflex triggered, NIPT result within 5โ7 business days |
| Sample Type / Matrix | Maternal peripheral blood (serum for immunoassay, whole blood for cfDNA extraction) |
| Methodology Used | Chemiluminescent Immunoassay (PAPP-A, free ฮฒ-hCG) โ Reflex Next-Generation Sequencing (cfDNA) |
| ICD-10-CM Code | Z36.81 |
| LOINC Code | 50826-8 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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