Prenatal Chromosomal Aneuploidy Screening (Karyotyping + FISH for Chromosomes 13, 18, 21, X, Y) in UAE | 2,400 AED

Executive Summary & Core Metrics

Executive Summary

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

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Test Overview & Methodology

This advanced prenatal diagnostic test combines full karyotyping with Fluorescence In‑Situ Hybridization (FISH) to detect numerical abnormalities of chromosomes 13, 18, 21, X, and Y in fetal cells obtained via amniocentesis or chorionic villus sampling (CVS). It delivers definitive aneuploidy results with unmatched specificity, enabling informed pregnancy decisions.

Feature	Our Test (Karyotyping + FISH)	Closest Alternative (NIPT)
Precision	Diagnostic – detects mosaicism, structural anomalies, and trisomies	Screening only; may miss mosaicism and structural rearrangements
Methodology	Cell culture + G‑banded karyotyping + targeted FISH	Cell‑free fetal DNA analysis from maternal blood
Turnaround	15–20 days (FISH preliminary in 48‑72 h)	5–7 days

Physician Insight & Safety Protocols

“As a genetic consultant, I stress that this test offers definitive chromosomal information, but results must always be integrated with detailed ultrasound findings and maternal clinical history. Shared decision-making with your obstetrician and genetic counselor is essential for optimal pregnancy management.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory Guidance

Important Safety Considerations

Correlate all genetic results with detailed anatomic ultrasound and maternal serum screening.
Discuss the risk of procedure-related miscarriage (approximately 1 in 300 to 1 in 500) and alternative screening options before consent.
Results may reveal incidental findings; pre-test counseling should address potential psychological impact.

Exclusion Criteria & ER Red Flags

Active vaginal bleeding, suspected amniotic fluid leakage, or fever (>38°C) at the time of sampling.
Known allergy to local anaesthetic agents (if used).
Emergency signs post‑procedure: heavy bleeding, severe abdominal pain, fever >38°C, or clear fluid gush – seek immediate ER care.

Patient FAQ & Clinical Guidance

1. What exactly does this prenatal test detect?

This diagnostic test definitively identifies numerical abnormalities of chromosomes 13, 18, 21, X, and Y using combined karyotyping and FISH. It can reveal trisomies (e.g., Down syndrome, Edwards, Patau), monosomy X (Turner), and sex chromosome variations, including mosaic patterns and certain structural rearrangements.

2. How is the fetal sample collected, and is it painful?

The sample is obtained via amniocentesis (amniotic fluid) or chorionic villus sampling (CVS) under continuous ultrasound guidance to ensure safety. A thin needle is inserted through the abdomen; local anaesthesia minimises discomfort, and the procedure is usually completed within a few minutes.

3. Is the procedure safe for both mother and baby?

When performed by an experienced specialist, the risk of procedure‑related miscarriage is approximately 1 in 300 to 1 in 500. Your doctor will assess individual risk factors and discuss all benefits and limitations before proceeding.

UAE Regulatory & Data Privacy Adherence

Regulatory Compliance

This prenatal diagnostic service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is securely handled in accordance with these regulations.

DHA Facility License Number: 1143 | Laboratory Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE

Corporate Lab Branding: DNA Labs UAE

Clinical & Logistical Metadata

Test Name	Prenatal Chromosomal Aneuploidy Screening (Karyotyping + FISH for Chromosomes 13, 18, 21, X, Y)
Price (AED)	2,400
Turnaround Time	15–20 days (FISH preliminary in 48–72 h)
Sample Type / Matrix	Amniotic fluid or Chorionic villus (CVS) – Hospital Extraction Only
Methodology Used	Cell culture + G‑banded karyotyping + targeted FISH
ICD-10-CM Code	Z36.0
LOINC Code	34513-0
DHA Facility License & Laboratory Address	License #1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE