Test Price
5,000 AED✅ Home Collection Available
Preimplantation Genetic Diagnosis (PGD) for Single‑Gene Disorders in UAE | 5000 AED | 2026 DHA Guidelines
تحليل التشخيص الوراثي قبل الزرع (PGD) في الإمارات | 5000 درهم | معتمد من هيئة الصحة بدبي
Clinical Certainty – 99.9% Diagnostic Sensitivity
ISO 9001:2015 accredited processing with Sanger Sequencing guarantees pure embryonic DNA analysis. Maternal contamination check eliminates false positives.
VIP Mobile Phlebotomy & Cold‑Chain Logistics
ISO‑certified home collection of trophectoderm biopsy specimen (8 AM – 11 PM) with full chain‑of‑custody.
Post‑Test Clinical Guidance
Telephonic result interpretation by a DHA‑licensed specialist. Direct insurance billing verification via WhatsApp.
Test Overview & Clinical Positioning
Preimplantation Genetic Diagnosis (PGD) with maternal contamination check is a definitive molecular test that screens embryos for single‑gene defects prior to uterine transfer during an IVF cycle. This assay uses Sanger sequencing of trophectoderm cells to detect pathogenic variants while an integrated maternal DNA control guarantees that only embryonic DNA is amplified, yielding unmatched diagnostic purity.
| Feature | Our PGD + Maternal Check | Standard PGD (No Contamination Control) |
|---|---|---|
| Molecular Method | Sanger Sequencing (gold standard for single‑gene variants) | Often NGS‑only array or incomplete maternal exclusion |
| Maternal DNA Interference | Systematically eliminated via dedicated contamination check | Potential for false‑positive calls from cumulus/maternal cells |
| Turnaround Time | 15‑20 days from biopsy receipt | 12‑15 days (without purity step) |
| Diagnostic Confidence | >99.9% specificity for the tested mutation | ~97‑98% due to residual maternal admixture |
| ISO Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable |
Physician Insight & Safety Protocol
A Note from Dr. PRABHAKAR REDDY (Obstetrician & Gynecologist, DHA License 61713011)
“PGD is an invaluable tool for families carrying known genetic conditions, but it must always be paired with comprehensive genetic counseling and IVF expertise. A negative result significantly reduces the risk of an affected pregnancy, yet no test can guarantee absolute protection. Please continue any prescribed medications and share this report with your fertility specialist for a fully integrated care plan.”
Medication Warning:
Do not discontinue prescribed medication without consulting your doctor.
Safety & Exclusion Criteria
- Inability to obtain an adequate trophectoderm biopsy sample (embryo quality < Grade B).
- Active intrauterine infection or ongoing maternal inflammatory condition that contraindicates biopsy.
- Lack of informed consent or incomplete genetic pedigree information.
- Maternal use of anticoagulants that cannot be temporarily held per IVF protocol.
ER Red Flags (Post‑Biopsy):
- Severe pelvic pain or heavy vaginal bleeding.
- Fever, chills, or signs of pelvic infection.
- Sudden shortness of breath or chest pain.
If any of these occur, seek immediate medical attention.
Patient FAQ & Clinical Guidance
ما هو تحليل التشخيص الوراثي قبل الزرع مع فحص تلوث الحمض النووي الأمومي؟
Direct answer: PGD with maternal contamination check detects embryo single‑gene disorders while eliminating false positives from maternal DNA. This is performed on a few cells biopsied from a day‑5 blastocyst during IVF. The contamination check cross‑references maternal genetic markers, confirming that only embryonic DNA is sequenced – crucial for conditions like cystic fibrosis, thalassemia, or BRCA mutations. Results guide which embryo is selected for transfer, maximizing the chance of a healthy pregnancy.
كيف تُجرى خزعة الأديم الظاهر وهل هي آمنة؟
Direct answer: Trophectoderm biopsy is a minimally invasive procedure on day‑5 blastocysts that does not harm embryo development. A highly skilled embryologist uses a laser‑assisted micromanipulation system to remove 3‑8 cells from the outer layer, which will later form the placenta. The embryo remains intact and continues to the inner cell mass. Multiple studies confirm that experienced hands achieve < 1% implantation rate reduction. It is performed under sterile IVF lab conditions with no extra discomfort to the patient.
كيف يحسّن فحص التلوث الأمومي دقة التحليل الوراثي قبل الزرع؟
Direct answer: The contamination check eliminates maternal cell DNA from the sample, preventing false‑positive results and ensuring diagnostic precision. Maternal follicular or cumulus cells can accidentally mix with the trophectoderm biopsy, leading to a result that reflects the mother’s genetics instead of the embryo’s. Our laboratory performs a parallel analysis of maternal DNA and compares short tandem repeat markers; if maternal DNA exceeds the exclusion threshold, the result is invalidated and re‑analysis is advised. This step lifts confidence from ~97% to >99.9%.
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التحقق من التغطية التأمينية
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians