Test Price
2,800 AED✅ Home Collection Available
TMEM127 Gene Pheochromocytoma Type 8 Genetic Test in UAE | 2800 AED | Accredited Molecular Diagnostics
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next Generation Sequencing (NGS) Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM, ensuring sample integrity from your residence to the laboratory.
- Clinical Guidance: Telephonic Post-Test Genetic Counselling and result interpretation provided by a board-certified Consultant Medical Geneticist.
- Insurance Support: Direct Billing Verification via WhatsApp +971 54 548 8731; subject to your insurer's coverage terms.
- Corporate Oversight: Laboratory operations supervised by Consultant Medical Geneticist Lina Osama Zaki Quteineh (DHA Registration ID: 9294403).
Test Overview & Methodology
The TMEM127 gene test utilizes Next Generation Sequencing (NGS) to detect germline mutations associated with familial pheochromocytoma type 8. This comprehensive molecular analysis enables precise risk stratification for individuals with a personal or family history of pheochromocytoma, facilitating tailored surveillance strategies and early intervention. The assay achieves a diagnostic sensitivity of 99.9% through deep bioinformatic analysis covering all coding exons and splice sites of the TMEM127 gene.
| Aspect | TMEM127 NGS (Our Test) | Single-Gene Sanger Sequencing |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; comprehensive variant detection including large deletions and duplications | ~97% sensitivity; limited to known point mutations within amplified fragments |
| Method | Next Generation Sequencing (NGS) with bioinformatic deep analysis across entire gene coding region | Sanger sequencing with single exon coverage per reaction |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
Physician Insight & Safety Protocols
Consultant Medical Geneticist Insight:
"The TMEM127 gene test represents a validated molecular tool for clarifying hereditary pheochromocytoma risk. However, results must always be interpreted within the full clinical picture, including biochemical markers and family pedigree analysis. Genetic counselling before and after testing is essential to ensure informed decision-making and appropriate cascade screening for at-risk relatives." — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403.
Important Advisory
Medication Notice: Do not discontinue, alter, or adjust any prescribed medication—including antihypertensives or alpha-blockers—without direct consultation with your treating physician. Genetic test results may influence future management decisions but should never prompt abrupt medication changes independently.
Exclusion Criteria & Emergency Red Flags
- This test is not indicated for individuals under 18 years without legal guardian consent, in accordance with UAE Federal Law No. 2 of 2019 concerning health data protections for minors.
- Pregnant women should consult their obstetrician before testing; mandatory genetic counselling is required as part of the testing pathway.
- Emergency Red Flags: If you experience sudden severe headache, palpitations, excessive sweating, or dangerously high blood pressure, seek immediate emergency medical attention—these may indicate a pheochromocytoma crisis requiring urgent intervention.
- Genetic privacy is strictly protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL); results are disclosed solely to the ordering physician or the patient's legal representative.
Patient FAQ & Clinical Guidance
1. What is the TMEM127 gene test used for?
This test detects germline mutations in the TMEM127 gene that cause familial pheochromocytoma type 8, a hereditary endocrine tumor syndrome. It enables early identification of at-risk individuals, guiding personalized surveillance to detect tumors at a treatable stage and allowing cascade testing for family members.
Clinical utility extends to preoperative risk assessment, surveillance planning for mutation carriers, and clarifying the genetic basis of apparently sporadic pheochromocytoma cases with young-onset or bilateral presentation.
2. What sample is required for the TMEM127 genetic test?
A standard peripheral whole blood sample (2–5 mL in an EDTA tube) is required. Our VIP Mobile Phlebotomy service will collect the sample at your home between 8 AM and 11 PM, utilizing temperature-controlled cold-chain transport to preserve DNA integrity.
Alternatively, extracted DNA or dried blood spot (FTA card) samples are acceptable if provided by your referring physician or hospital laboratory.
3. How long does it take to get results?
Results are typically available within three to four weeks from sample receipt at the laboratory. This timeline ensures thorough NGS sequencing, bioinformatic analysis, variant interpretation against population databases, and expert review by our Consultant Medical Geneticist.
You will receive a secure digital report and can schedule a telephonic consultation with the geneticist to discuss findings, implications, and recommended follow-up steps.
4. Is genetic counselling included with the test?
Yes, pre-test and post-test genetic counselling is a mandatory component of this testing pathway. Our Consultant Medical Geneticist will discuss the implications of possible results, including the potential for incidental findings, before sample collection.
After results are available, a dedicated telephonic session provides personalized interpretation, risk communication, and cascade testing recommendations for at-risk family members, all compliant with UAE privacy regulations.
5. What insurance plans cover the TMEM127 test?
Coverage varies by insurer and policy. We offer direct billing verification through WhatsApp at +971 54 548 8731 to confirm your eligibility before testing.
Our team will assist with pre-authorization documentation and provide a detailed invoice for insurance reimbursement if direct billing is not applicable.
UAE Regulatory & Data Privacy Adherence
Legal & Regulatory Compliance Framework:
- Personal Data Protection: All genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring your genomic information remains confidential and is used solely for diagnostic purposes with your explicit consent.
- Health Information Governance: Laboratory information systems and data handling procedures adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, securing electronic health records and genetic test results against unauthorized access.
- Clinical Safety & Patient Consent: Testing protocols and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all genetic testing is performed with informed consent and that results are communicated responsibly by qualified healthcare professionals.
- Quality Accreditation: The laboratory operates under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and DHA Facility License No. 1143, undergoing regular audits to maintain the highest standards of diagnostic accuracy and data security.
Clinical & Logistical Metadata
| Test Name | TMEM127 Gene Pheochromocytoma Type 8 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA), extracted DNA, or FTA card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next Generation Sequencing (NGS) – comprehensive gene sequencing covering all coding exons and splice sites |
| ICD-10-CM Code | Z15.09 (Genetic susceptibility to other malignant neoplasm), D44.7 (Neoplasm of uncertain behavior of adrenal gland) |
| LOINC Code | 74883-4 (TMEM127 gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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