Test Price
700 AED✅ Home Collection Available
High-Resolution HLA-B*1502 Genotyping (Carbamazepine) – DHA Licensed Pharmacogenetic Screening
Executive Summary & Core Metrics
This single-gene pharmacogenetic assay delivers 99.9% diagnostic sensitivity for carbamazepine-induced severe cutaneous adverse reactions (SCARs) via ISO 9001:2015-accredited bidirectional Sanger sequencing. Designed as a definitive pre-therapy screening tool, it identifies the HLA-B*1502 allele to prevent life-threatening Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in at-risk populations.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Sanger Sequencing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Genetic Counseling by a DHA-Licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodological Precision
The HLA-B*1502 allele is a critical pharmacogenetic marker strongly associated with carbamazepine-induced SJS and TEN, particularly in Han Chinese, Thai, and other Southeast Asian populations. This definitive DNA-based test identifies at-risk individuals before therapy begins, directly aligning with DHA precision medicine mandates and international clinical guidelines.
| Feature | Gold-Standard Sanger Sequencing | Closest Alternative (PCR-SSO Strip) |
|---|---|---|
| Precision | Nucleotide-level resolution; 100% specificity for HLA-B*1502 | Probe-based; may miss rare variants or cross-react |
| Methodology | Bidirectional Sanger Sequencing of exon 2–3 | Reverse SSO hybridization |
| Turnaround | 10 Working Days | 7–14 Days (Often Outsourced) |
| Regulatory | DHA/MOHAP Compliant, ISO 9001:2015, LOINC 79529-5 | Varies; Often No UAE-Specific Validation |
Clinical Oversight & Safety Governance
"As a Consultant Medical Genetics specialist at DNA Labs UAE, I emphasize that HLA-B*1502 screening is a non-negotiable prerequisite for initiating carbamazepine in patients of Asian descent. This single-gene assay provides the definitive molecular evidence needed to prevent catastrophic SCARs. However, a negative result does not entirely eliminate the need for clinical vigilance regarding idiosyncratic drug reactions."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ CRITICAL SAFETY NOTICE
Do not discontinue prescribed medication without consulting your doctor. Abrupt withdrawal of carbamazepine may provoke seizures or severe mood destabilization.
Urgent ER Red Flags: If you develop a rapidly spreading rash, blisters on skin or mucous membranes, fever, or conjunctivitis after starting carbamazepine, seek emergency care immediately—do not wait for test results.
Exclusion Criteria for Home Collection
Known active severe skin reaction requiring hospitalization; ongoing chemotherapy causing pancytopenia; inability to provide informed consent (guardian required for minors per UAE Federal Law). A physician’s prescription is generally required unless the test is performed for pre-surgical clearance or travel abroad—please consult our support team.
Patient FAQ & Clinical Guidance
1. What is HLA-B*1502 genotyping, and why is it essential before carbamazepine therapy?
This genetic test detects a high-risk allele that can predict severe, potentially fatal skin reactions to carbamazepine, enabling safer prescribing. Clinical guidelines strongly recommend screening in at-risk ethnic groups prior to initiating treatment; a negative result allows carbamazepine use with significantly reduced risk, while a positive result necessitates alternative anticonvulsant therapy.
2. How does the home collection process ensure sample integrity?
Our DHA-licensed mobile phlebotomists use ISO-certified cold-chain transport (2–8°C) to keep your blood sample stable until laboratory processing. A single venipuncture from your arm is performed at your residence or office, with real-time temperature monitoring and full chain-of-custody documentation to guarantee specimen viability for sequencing.
3. How will I receive my results, and what is the next step?
Results are delivered within 10 working days via a secure PDF report that clearly states HLA-B*1502 positivity or negativity. A positive result indicates high risk for carbamazepine hypersensitivity—your physician will consider alternative anticonvulsants or mood stabilizers. A complimentary telephonic consultation with our genetic counselor is available to discuss clinical implications.
4. Does insurance cover this pharmacogenetic test?
Coverage varies by insurance provider and plan. Our support team facilitates direct billing verification; you can initiate this process by sending a copy of your insurance card via WhatsApp to +971 54 548 8731. We will confirm your outpatient genetic testing benefits prior to sample collection.
UAE Regulatory & Data Privacy Adherence
Governance & Legal Frameworks
DNA Labs UAE strictly processes all patient data under the provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety, patient consent, and medical liability protocols are rigorously aligned with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | HLA-B*1502 Genotyping (Carbamazepine Pharmacogenetics) |
| Price (AED) | 700 |
| Turnaround Time | 10 Working Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA Tube) |
| Methodology Used | Gold-Standard Bidirectional Sanger Sequencing (Exon 2–3) |
| ICD-10-CM Code | Z13.89 |
| LOINC Code | 79529-5 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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