Test Price
2,800 AED✅ Home Collection Available
KRT16 Gene Palmoplantar Keratoderma, Nonepidermolytic, Focal Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Excellence Guarantee
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
This advanced genetic test employs next-generation sequencing (NGS) to deliver a definitive molecular diagnosis of focal nonepidermolytic palmoplantar keratoderma caused by pathogenic KRT16 variants, achieving 99.9% analytical sensitivity within an ISO 9001:2015 accredited laboratory. A mandatory pre-test genetic counselling session for pedigree charting of affected family members is required prior to sample collection.
Test Overview & Methodology
The KRT16 gene test identifies pathogenic variants in the KRT16 gene responsible for focal nonepidermolytic palmoplantar keratoderma, enabling precise diagnosis and personalized management. This next-generation sequencing (NGS) analysis provides comprehensive coding region coverage with 99.9% analytical sensitivity, delivering clinically actionable results for hereditary palmoplantar keratoderma in UAE patients.
Pre-test Requirement: A genetic counselling session to draw a pedigree chart of family members affected with KRT16 gene palmoplantar keratoderma, nonepidermolytic, focal is mandatory before sample collection.
Comparative Analysis of Testing Methods
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Method | Next-Generation Sequencing (NGS) | Sanger Sequencing (single exon) |
| Gene Coverage | Full KRT16 gene (all exons ±20 bp) | Limited to known mutations |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Diagnostic Yield | >99% for coding variants | ~70% if hotspot only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403: “As a consultant medical geneticist, I emphasize that while this NGS-based test provides definitive molecular confirmation of KRT16-related keratoderma, clinical correlation with physical findings and family history remains essential. This result should guide but not replace ongoing dermatologic and genetic care. Please discuss all treatment options, including topical keratolytics and systemic retinoids, with your doctor before making any changes.”
Advisory Notice
Medication Warning
Do not discontinue or alter prescribed medication without consulting your doctor. Genetic test results must be integrated into a comprehensive treatment plan managed by a qualified physician. Abrupt changes may lead to adverse outcomes.
Exclusion Criteria & Safety Precautions
Contraindications for Sample Collection
- Active infection or open lesions at the blood collection site.
- Inability to provide informed consent (pediatric patients require legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Severe bleeding diathesis or current anticoagulant therapy not yet cleared by physician.
Emergency Red Flags: Seek immediate medical attention if you experience rapid progression of skin thickening, severe pain, signs of secondary bacterial infection (pus, foul odor, fever), or allergic reaction after sample collection.
Patient FAQ & Clinical Guidance
1. What is the KRT16 gene test?
The KRT16 genetic test detects mutations in the KRT16 gene causing focal nonepidermolytic palmoplantar keratoderma with high precision. It uses next-generation sequencing to analyze all coding exons of the gene, enabling a definitive molecular diagnosis for inherited thickening of the palms and soles.
2. How is the sample collected?
A simple blood draw, extracted DNA, or a drop of blood on an FTA card is collected through our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service, available daily from 8 AM to 11 PM. The collection is performed by a DHA-licensed phlebotomist using sterile, single-use equipment.
3. What is the turnaround time for results?
Results are typically ready within 3 to 4 weeks, with a comprehensive report reviewed by our consultant medical geneticist. The report includes variant classification according to ACMG standards, clinical interpretation, and actionable recommendations.
4. Is pre-test genetic counselling required?
Yes, a mandatory pre-test genetic counselling session is required to draw a pedigree chart of family members affected with KRT16-related palmoplantar keratoderma. This ensures informed consent and appropriate test selection.
5. Can this test be done during pregnancy?
Prenatal genetic testing for KRT16 is possible but requires specialized counselling and coordination with a maternal-fetal medicine specialist. Please contact our genetic counselling team for individualized guidance.
UAE Regulatory & Data Privacy Adherence
Data Protection & Healthcare Compliance Framework
DNA Labs UAE operates under the strict regulatory oversight of the Dubai Health Authority (DHA) and complies with all applicable UAE federal laws governing patient data privacy and healthcare information security.
- Personal Data Protection: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Governance: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability & Patient Consent: All clinical procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring informed consent and patient safety.
Your genetic data is encrypted, stored securely, and never shared with third parties without your explicit written consent. You retain the right to access, correct, or request deletion of your data in accordance with PDPL provisions.
Clinical & Logistical Metadata
| Test Name | KRT16 Gene Palmoplantar Keratoderma, Nonepidermolytic, Focal Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS), Full KRT16 Gene Coverage (All Exons ±20 bp) |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 94321-1 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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