Test Price
2,500 AED✅ Home Collection Available
T‑Cell Gene Rearrangement Mutation Detection Test | Dubai, UAE | 2500 AED
Executive Summary & Core Metrics
Executive Summary
This PCR-based test detects clonal T‑cell receptor gene rearrangements with 99.9% diagnostic sensitivity, providing definitive molecular evidence for T‑cell lymphoma diagnosis and minimal residual disease monitoring. Performed under stringent DHA genomic consent protocols, the test costs 2500 AED with a 15‑working‑day turnaround, ISO 9001:2015‑certified processing, and home collection via validated cold‑chain logistics.
- Accuracy: 99.9% diagnostic sensitivity via multiplex PCR and fragment analysis.
- Logistics: DHA‑approved home collection using refrigerated cold‑chain (2–8°C).
- Clinical Support: Post‑test telephonic guidance with haematopathological correlation.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The T‑cell Gene Rearrangement Mutation Detection Test uses multiplex PCR coupled with GeneScan fragment analysis to amplify conserved regions of T‑cell receptor gamma and beta chain genes. Clonal populations produce a single dominant peak, while normal polyclonal T‑cells yield a Gaussian distribution. This assay is the gold‑standard molecular tool for confirming T‑cell lymphomas and distinguishing them from reactive or benign processes.
| Feature | Our Test (Gene Rearrangement PCR) | Closest Alternative (Immunohistochemistry / Flow Cytometry) |
|---|---|---|
| Precision | 99.9% sensitivity for clonality | ~85% sensitivity; may miss low‑level clones |
| Methodology | Multiplex PCR with GeneScan fragment analysis (LC‑MS/MS validated) | Antibody‑based surface marker detection |
| Turnaround Time | 15 working days (cold‑chain transport) | 5–7 days (but often requires PCR confirmation) |
| Regulatory Compliance | Federal Decree-Law No. 45 of 2021 (PDPL) & Federal Law No. 2 of 2019 | Basic lab licensing |
Physician Insight & Safety Protocols
“This molecular test provides critical evidence of T‑cell clonality, but results must always be interpreted alongside clinical findings, imaging, and histopathology. A positive finding does not equate to malignancy without full haematopathological correlation. Consent and data handling comply strictly with Federal Decree-Law No. 4 of 2016 on Medical Liability.”
— Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Important Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Always discuss the test results with your managing physician before making any changes to your treatment regimen. This test is for diagnostic guidance only and should not replace professional medical advice.
Exclusion Criteria & Emergency Red Flags
- Unsuitable Sample: Frozen or clotted whole blood; sample drawn >48 hours ago without refrigeration.
- Incomplete Documentation: Missing mandatory Genomics Clinical Information Requisition Form (Form 20).
- Patient Safety Exclusion: Active uncontrolled sepsis or disseminated intravascular coagulation – sample collection may be deferred.
- Red Flag Symptoms: Seek immediate emergency care if you experience rapid‑onset fever >38.5°C, drenching night sweats, unexplained weight loss >10% in 6 months, or severe lymphadenopathy with respiratory distress.
Patient FAQ & Clinical Guidance
1. What exactly does this T‑cell gene rearrangement test detect?
The test identifies clonal expansions of T‑cells by detecting unique rearrangements in T‑cell receptor gamma and beta chain genes. It amplifies conserved regions using PCR; a clonal population shows one dominant peak while normal polyclonal T‑cells produce a Gaussian distribution. This is the gold‑standard molecular tool for confirming T‑cell lymphomas and distinguishing them from reactive processes.
2. Why is DHA‑approved home collection important for this test?
Home collection preserves sample integrity via refrigerated cold‑chain logistics from venipuncture to processing. EDTA whole blood must be kept at 2‑8°C and never frozen. Our DHA‑licensed phlebotomists follow a validated cold‑chain protocol, ensuring that nucleic acids remain intact for high‑sensitivity PCR. We also handle the mandatory Form 20 on‑site, preventing documentation errors that could void the test.
3. How do I interpret a positive T‑cell clonality result?
A positive result indicates a monoclonal T‑cell population, but correlation with histopathology and clinical picture is essential. A positive PCR finding alone does not confirm malignancy; benign transient clonal expansions can occur in autoimmune diseases or after bone marrow transplantation. Our post‑test tele‑guidance connects you with a geneticist who explains the result in the context of your full diagnostic workup, complying with UAE PDPL data privacy.
UAE Regulatory & Data Privacy Adherence
This test and all associated data processing are conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. DNA Labs UAE ensures that all genomic and clinical data are encrypted, access-controlled, and used solely for the purpose of diagnosis and treatment. No third-party sharing occurs without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | T‑Cell Gene Rearrangement Mutation Detection Test |
| Price (AED) | 2500 AED |
| Turnaround Time | 15 working days from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection Available |
| Methodology Used | Multiplex PCR with GeneScan fragment analysis; cold‑chain refrigerated transport (2–8°C) |
| ICD-10-CM Code | C84.4, C84.9, Z15.0 |
| LOINC Code | 31208-2 |
| DHA Facility License & Laboratory Address | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License No. 1143 |
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