Test Price
1,600 AED✅ Home Collection Available
cKIT Mutation Screening (Exons 9, 11, 13, 17) in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Specimen Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval for archival tumor tissue (FFPE blocks or biopsy slides).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The cKIT mutation screening examines exons 9, 11, 13, and 17 of the KIT gene in tumor tissue to confirm a diagnosis of gastrointestinal stromal tumor (GIST) and guide targeted therapy with tyrosine kinase inhibitors. This ISO-certified Sanger sequencing test, priced at AED 1,600 with a 7–8 day turnaround time, provides precise mutation profiling essential for prognostic and therapeutic decision-making.
| Feature | Our cKIT Sanger Sequencing | Comprehensive NGS GIST Panel |
|---|---|---|
| Precision | >99.9% analytical sensitivity for targeted exons | High sensitivity for multiple genes but may miss low-frequency variants |
| Methodology | Gold-standard Sanger Sequencing (ISO 9001:2015) | Next-Generation Sequencing (NGS) with bioinformatics complexity |
| Turnaround Time | 7–8 days | 10–14 days typical |
| Cost in UAE | AED 1,600 | AED 4,500+ |
| Clinical Focus | Direct detection of activating and resistance mutations in KIT necessary for imatinib therapy | Broad profiling including PDGFRA, SDH, etc.; may overcomplicate for initial GIST diagnosis |
Physician Insight & Safety Protocols
Mr. Prabhakar Reddy Kalathoor (Specialist Diagnostic Radiology, DHA License: 61713011) states: "This screening is a cornerstone in personalizing GIST therapy. A positive cKIT mutation, especially in exon 11, strongly predicts response to imatinib. However, even a negative result must be correlated with histopathology and clinical presentation, as rare PDGFRA or wild-type GISTs exist. I always counsel patients that mutation testing empowers treatment but does not replace comprehensive oncologic evaluation."
Medication Advisory
IMPORTANT: Do not discontinue any prescribed medication, especially tyrosine kinase inhibitors, without consulting your oncologist. Abrupt cessation can lead to disease flare.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion criteria: Active, uncontrolled bleeding from tumor site; hemodynamic instability. Pregnancy — test only if essential and with specialist consultation. Children under 18 years require parental consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flags (Seek immediate ER if): Sudden, severe abdominal pain or peritoneal signs; hematemesis or melena; signs of tumor lysis syndrome (muscle cramps, cardiac arrhythmia, oliguria); acute onset of neurological deficits. Do not wait for test results.
If you experience any of the above, call emergency 998 or visit the nearest hospital immediately.
Patient FAQ & Clinical Guidance
1. What does a positive cKIT mutation in exon 11 mean for my GIST treatment?
A positive cKIT exon 11 mutation predicts an excellent response to imatinib therapy, guiding your oncologist to a highly effective targeted treatment plan.
2. Is a 7–8 day turnaround time fast enough for urgent treatment decisions?
Our optimized Sanger sequencing and logistics guarantee reliable results within 7–8 days, supporting timely initiation of targeted therapy without compromising accuracy.
3. Can this test be performed using blood instead of tumor tissue?
cKIT mutation screening requires tumor tissue from biopsy or surgical resection; blood-based liquid biopsies are not validated for exon-specific GIST mutations. Secure Medical Courier Solid Tissue Specimen Retrieval is used for all archival tissue samples.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed under strict confidentiality protocols with secure encryption and access control measures. Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | cKIT Mutation Screening (Exons 9, 11, 13, 17) |
| Price (AED) | 1,600 |
| Turnaround Time | 7–8 days |
| Sample Type / Matrix | Tumor Tissue (FFPE block or biopsy slide) |
| Methodology Used | Sanger Sequencing (ISO 9001:2015) |
| ICD-10-CM Code | C49.9 |
| LOINC Code | 21661-6 |
| DHA Facility License & Laboratory Address Invariants | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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