Test Price
800 AED✅ Home Collection Available
NPM1 Mutation Analysis (Exon 12 Insertion) in UAE | 800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
- Premium Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Complimentary Telephonic Post-Test Result Interpretation by Senior Clinical Pathologists.
- Insurance: Direct Billing Verification & Claim Support – WhatsApp +971 54 548 8731.
Compliance: This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability. Facility License: DHA 1143. Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Test Overview & Methodology
NPM1 Mutation Analysis (Exon 12 Insertion) is a molecular diagnostic test that detects the most common NPM1 mutation in acute myeloid leukemia (AML). It provides critical data for risk stratification, minimal residual disease monitoring, and personalized treatment planning. The test uses gold‑standard Sanger sequencing to identify insertions in exon 12 of the NPM1 gene.
| Parameter | Our Test (DNA Labs UAE Pathway) | Closest Alternative (Local Average) |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity (Capillary Sanger Sequencing) | ~95% with NGS panels (may miss small insertions) |
| Methodology | Gold-Standard Sanger Sequencing (ABI 3730xl) | Next-Generation Sequencing or Fragment Analysis |
| Turnaround Time | 7–8 Business Days (Expedited Reporting Available) | 10–14 Days |
| Sample Collection | Hospital Extraction Only – Bone marrow or peripheral blood drawn in accredited facility | Clinic Visit Only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA License: 9294403) notes:
“As a Consultant Medical Genetics, I emphasise that an NPM1 exon 12 insertion is a strong favourable prognostic marker in AML, but it must always be interpreted alongside a complete cytogenetic and molecular workup. A positive result does not replace the need for bone marrow biopsy or comprehensive risk assessment. Treatment decisions should be guided by a multidisciplinary haematology‑oncology team.”
Medication Advisory
Do not discontinue or alter any prescribed medication without first consulting your treating physician. This test is an adjunct to clinical evaluation, not a substitute for ongoing therapy.
Safety Exclusion Criteria & Red Flags
- Exclusion Criteria: This test is not indicated for asymptomatic screening or for use without a clinical haematology referral. Not recommended as a sole test during pregnancy without maternal‑fetal medicine approval.
- Emergency Red Flags: If you develop new unexplained bruising, prolonged bleeding, persistent fever, or severe fatigue, proceed to the nearest emergency department immediately.
- Paediatric Notice: For minors, parental consent is required in accordance with UAE health regulations.
Patient FAQ & Clinical Guidance
1. What is NPM1 mutation analysis (exon 12 insertion) and why is it important?
Snippet: NPM1 exon 12 insertion test predicts AML outcome, helping oncologists personalise therapy and monitor response. This genetic test detects a specific mutation in the NPM1 gene that occurs in approximately 30% of adult acute myeloid leukaemias. The result is used to classify risk (favourable vs. intermediate) and to track minimal residual disease after chemotherapy, enabling more precise treatment strategies.
2. How is the sample collected for NPM1 testing in the UAE?
Snippet: Hospital extraction of bone marrow or blood with cold‑chain provides accurate NPM1 exon 12 analysis. Sample collection is conducted strictly within an accredited hospital facility. A qualified phlebotomist draws 2–3 mL of bone marrow or peripheral blood into EDTA tubes. Samples are immediately placed into validated cold‑chain transport (2–8°C), preserving RNA/DNA integrity until molecular analysis at our ISO‑certified laboratory.
3. How long do results take, and what should I do once I receive them?
Snippet: Results are ready in 7–8 days; contact your haematologist immediately to discuss mutation‑specific AML treatment. A detailed molecular report will be delivered via secure email. Do not interpret the result alone; a positive NPM1 mutation typically indicates a favourable prognosis but requires integration with other diagnostic markers. Our team offers a free telephonic guidance call to clarify the implications before your specialist appointment.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted end‑to‑end, accessible only to authorised clinical personnel, and used solely for diagnostic and therapeutic purposes. We maintain strict confidentiality and do not share data without explicit patient consent.
Our laboratory operates under DHA Facility License 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | NPM1 Mutation Analysis (Exon 12 Insertion) |
| Price (AED) | 800 |
| Turnaround Time | 7–8 Business Days |
| Sample Type / Matrix | Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. |
| Methodology Used | Gold-Standard Sanger Sequencing (ABI 3730xl) |
| ICD-10-CM Code | C92.00 (Acute myeloblastic leukemia, not having achieved remission) |
| LOINC Code | 48766-0 (NPM1 gene mutations detected in Blood or Bone marrow by Molecular genetics method) |
| DHA Facility License & Laboratory Address | License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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