Test Price
2,800 AED✅ Home Collection Available
SOS1 Gene Noonan Syndrome Type 4 Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next-generation sequencing (NGS) processing.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation provided directly by a Consultant Medical Geneticist.
- Insurance & Billing: Direct billing verification available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SOS1 Gene Noonan Syndrome Type 4 Genetic Test is a high-resolution next-generation sequencing (NGS) assay that comprehensively screens the coding region of the SOS1 gene. This test is indicated for pediatric and adult patients presenting with dysmorphic features, short stature, congenital heart defects, or a positive family history of Noonan syndrome. It serves as a definitive molecular tool for clinical management, genetic counseling, and cancer surveillance planning.
By utilizing robust full exon capture technology, the assay delivers a mean read depth exceeding 100x, ensuring confident detection of single nucleotide variants and small insertions or deletions. Positive findings are confirmed via orthogonal sequencing methods to guarantee accuracy.
| Feature | Our Test: SOS1 NGS | Closest Alternative: Standard Noonan Panel |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for coding variants | 90-95% sensitivity across multiple genes |
| Methodology | Next Generation Sequencing (NGS) with full exon capture | NGS multi-gene panel |
| Turnaround Time | 14 – 21 Business Days (fast-track available) | 4 – 6 Weeks |
Physician Insight & Safety Protocols
Dr. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes: “An SOS1 gene test can provide families with long-awaited answers, but a positive result is only the beginning. It must be interpreted in the full clinical context by a multidisciplinary team. Genetic counseling is essential to understand implications for the child, parents, and future pregnancies.”
Clinical Advisory & Best Practices
Important Clinical Guidance
This genetic test is designed for diagnostic confirmation and risk assessment. It does not replace routine clinical examinations or ongoing medical management. Patients are advised to provide a complete family history to facilitate accurate interpretation of results.
Patient Exclusion Criteria & Precautions
Contraindications for Sample Collection
- Inability to provide informed consent (or legal guardian consent for minors, adhering to Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Uncontrolled bleeding disorder prior to venous sample collection; discuss with your referring physician.
- Active febrile illness – postpone collection unless medically urgent.
Patient FAQ & Clinical Guidance
1. What is the SOS1 gene test, and why is it ordered?
This test detects pathogenic SOS1 gene variants responsible for Noonan syndrome type 4, ensuring precise clinical diagnosis and genetic counseling. It is typically ordered for children or adults with characteristic facial features, congenital heart defects, short stature, or a family history suggestive of Noonan syndrome. Results guide medical surveillance, treatment planning, and family risk assessment.
2. How is the sample collected, and is it safe for children?
A certified phlebotomist performs a standard venous blood draw using pediatric-friendly techniques, or a single buccal swab can be used for minimal discomfort. The procedure is quick, safe, and fully compliant with UAE pediatric care standards. Alternatively, pre-extracted DNA may be submitted if available.
3. Does a negative SOS1 result rule out all forms of Noonan syndrome?
A negative result only excludes the SOS1 subtype; other genes (e.g., PTPN11, KRAS, RAF1) can also cause Noonan syndrome, so further testing may be recommended if clinical suspicion remains high. Genetic counseling will help interpret the result and decide on next steps.
UAE Regulatory & Data Privacy Adherence
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed under full confidentiality and patient rights protection. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). DHA/MOHAP standard nomenclature applied.
Clinical & Logistical Metadata
| Test Name | SOS1 Gene Noonan Syndrome Type 4 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 14 – 21 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood or Buccal Swab (VIP Mobile Phlebotomy & Home Collection Available) |
| Methodology Used | Next Generation Sequencing (NGS) with Full Exon Capture |
| ICD-10-CM Code | Q87.1 |
| LOINC Code | 21735-5 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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