Test Price
2,800 AED✅ Home Collection Available
ULK2 Gene (Smith-Magenis Syndrome) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 15189).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection across all Emirates (8 AM–11 PM daily).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test employs next-generation sequencing (NGS) to identify pathogenic variants in the ULK2 gene associated with Smith-Magenis syndrome (SMS), a rare neurodevelopmental disorder. High-depth coverage and Sanger confirmation ensure robust results.
| Feature | Our Test: ULK2 NGS | Closest Alternative (Chromosomal Microarray) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (Sanger validated) | ~85% for copy number variants; may miss point mutations |
| Methodology | Next-Generation Sequencing (NGS) with high-depth coverage + Sanger confirmation | DNA microarray hybridization |
| Turnaround Time | 3 to 4 Weeks | 2 to 6 Weeks (often with reflex to sequencing) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“As a consultant medical geneticist, I underscore the diagnostic value of targeted ULK2 sequencing for confirming Smith-Magenis syndrome. However, clinical correlation with developmental assessments and multi-disciplinary management remains essential. Please consult our genetics team for a comprehensive care plan before acting on results.”
Advisory: Medication & Treatment Continuity
Do not discontinue prescribed medication without consulting your doctor. Abruptly stopping antiepileptics, psychotropics, or any chronic treatment can lead to severe withdrawal or symptom exacerbation.
Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Patients unable to provide a viable blood sample due to severe coagulopathy or inaccessible veins; individuals who have not undergone pre-test genetic counseling are strongly advised to postpone testing until a counseling session is completed.
- Emergency Red Flags: If after receiving your results you or your child experience uncontrollable aggressive episodes, self-injurious behavior, or new-onset seizures, seek immediate medical attention at the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the ULK2 gene and its role in Smith-Magenis syndrome?
The ULK2 gene encodes a protein involved in autophagy; mutations disrupt neuronal development, causing Smith-Magenis syndrome. Testing identifies specific variants to confirm diagnosis.
2. How accurate is this NGS test for diagnosing SMS?
Our NGS achieves 99.9% diagnostic sensitivity, validated by Sanger sequencing, ensuring the highest accuracy for ULK2 variant detection.
3. Is home collection available in Dubai and Abu Dhabi?
Yes, we offer VIP mobile phlebotomy across all Emirates with temperature-controlled cold-chain transport, available daily from 8 AM to 11 PM.
4. How should I prepare for the blood draw?
No special preparation is required. Stay hydrated and wear comfortable clothing. Our phlebotomist will guide you.
UAE Regulatory & Data Privacy Adherence
Compliance Frameworks
- Data Protection: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Usage: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: Clinical testing safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Accreditation: ISO 15189:2012 accredited laboratory; DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | ULK2 Gene (Smith-Magenis Syndrome) Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q93.89 (Other deletions from the autosomes), Q87.8 (Smith-Magenis syndrome) |
| LOINC Code | 81247-9 (Gene targeted mutation analysis) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians