Test Price
2,800 AEDโ Home Collection Available
MATR3 Gene Amyotrophic Lateral Sclerosis Type 21 (ALS21) Genetic Test in UAE | 2,800 AED | DHA Licensed Facility
Executive Summary & Core Metrics
- ๐งฌ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). Full coding region analysis of MATR3 with NGS technology.
- ๐ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM by DHA-licensed professionals. Sample integrity ensured from draw to lab.
- ๐ฉบ Clinical Guidance: Post-test telephonic genetic counseling by certified genetics consultants. Results interpreted in English with actionable recommendations for you and your treating physician.
- ๐ Insurance: Direct billing verification available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test analyzes the complete coding region of the MATR3 gene to detect pathogenic variants responsible for Amyotrophic Lateral Sclerosis type 21 (ALS21), a severe motor neuron disorder with autosomal dominant inheritance. Utilizing next-generation sequencing (NGS) on the Illumina NovaSeq platform, the assay achieves comprehensive coverage of all exons and splice sites, enabling the detection of single nucleotide variants, small insertions and deletions, and copy number alterations with >99.9% sensitivity. Bioinformatic analysis employs validated pipelines aligned with ACMG guidelines for variant classification.
| Feature | Our MATR3 ALS21 NGS Test | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Precision | Full gene coverage: SNVs, indels, CNVs detected in coding and splice regions | Limited to selected exons only; CNVs not detectable |
| Methodology | NGS (Illumina NovaSeq) with bioinformatic analysis >99.9% sensitivity | Sanger sequencing; lower throughput, higher per-base cost |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks |
Physician Insight & Safety Protocols
โAs a consultant medical geneticist, I stress that a positive MATR3 result must be contextualized within the patientโs full neurological examination, family pedigree, and clinical trajectory. Genetic findings are one piece of a larger diagnostic mosaic. My team and I ensure every patient receives dedicated post-test counseling to navigate the medical and emotional dimensions of this diagnosis. Never initiate, adjust, or discontinue any prescribed therapy based exclusively on this genetic report without direct consultation with your treating neurologist.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Best Practice Guidelines
Informed consent must be obtained prior to sample collection, with clear communication regarding the potential for uncovering presymptomatic disease risk, implications for blood relatives, and the psychosocial impact of results. Pre-test genetic counseling to construct a three-generation pedigree is strongly recommended. Testing of minors requires explicit legal guardian consent per UAE federal regulations. Pregnant individuals should defer testing unless there is immediate clinical necessity evaluated by a specialist.
Safety Exclusion & Emergency Red Flags
- Exclusion Criteria: Testing is not performed on individuals without valid informed consent. Acute psychiatric instability or inability to comprehend the implications of testing requires deferral until capacity is restored.
- Emergency Signs: Sudden worsening of muscle weakness, difficulty breathing, choking while swallowing, or acute loss of speech โ call 998 immediately. This genetic test does not replace emergency neurological evaluation.
- Medication Warning: Do not stop or modify prescribed medications such as riluzole, edaravone, or any supportive therapy without direct guidance from your treating specialist.
Patient FAQ & Clinical Guidance
1. What is the MATR3 gene and how does it relate to ALS type 21?
Pathogenic mutations in the MATR3 gene disrupt ribonucleoprotein metabolism within motor neurons, leading to progressive degeneration characteristic of ALS type 21. This test identifies disease-causing variants across the entire coding region, enabling a molecular diagnosis that guides prognosis and family counseling.
2. Who should consider this genetic test?
Individuals with a clinical diagnosis of ALS and a family history suggestive of autosomal dominant inheritance should pursue MATR3 testing. Asymptomatic adult relatives of a known mutation carrier may also be tested after thorough pre-test genetic counseling. A neurologist or medical geneticist referral is required.
3. How is the test performed and what sample is required?
A peripheral whole blood sample (3โ5 mL in an EDTA tube) is collected by a DHA-licensed phlebotomist during a home visit or at a clinic. Samples are transported under strict temperature-controlled cold chain to our ISO 9001:2015 accredited laboratory. DNA is extracted and analyzed by NGS. Results are reported within 3โ4 weeks.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is never shared with third parties without explicit written authorization.
Clinical & Logistical Metadata
| Test Name | MATR3 Gene ALS21 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA Tube) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Illumina NovaSeq Platform |
| ICD-10-CM Code | G12.21 (Familial amyotrophic lateral sclerosis) |
| LOINC Code | 94765-5 (MATR3 gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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