Test Price
2,800 AED✅ Home Collection Available
TREM2 Gene Sequencing for Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (Nasu-Hakola Disease) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين TREM2 لمرض التكلس العظمي الشحمي الغشائي المتعدد الكيسات مع تلين الدماغ الأبيض (داء ناسو-هاكولا) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary (الملخص التنفيذي)
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed neurologist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ضمان دقة تشخيصية بنسبة 99.9٪ عبر خدمات منزلية معتمدة، واستشارة سريرية هاتفية لنتائجكم.
Why This Test Matters: Nasu-Hakola Disease Genetic Analysis
The TREM2 Gene Sequencing test detects pathogenic variants responsible for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease—a rare autosomal-recessive disorder characterized by progressive presenile dementia and bone cysts. This NGS-based analysis empowers precise diagnosis, aids family planning, and differentiates PLOSL from other neurodegenerative or skeletal dysplasias.
| Feature | Our TREM2 NGS Test | Alternate (Single-Gene Sanger) |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) with full coding region & splice site analysis, >99% coverage | Sanger sequencing of select exons |
| Variant Detection | SNVs, indels, copy number variants (CNVs) via advanced bioinformatics | Point mutations only; may miss large deletions/duplications |
| Turnaround Time | 3–4 Weeks, with expedited reporting for urgent cases | 2–3 Weeks but limited scope |
Physician Insight & Safety Protocol
From Dr. Prabhakar Reddy (DHA License: 61713011): “A positive TREM2 mutation confirms Nasu-Hakola disease, but clinical correlation with neuroimaging and skeletal surveys is essential. Genetic counselling is strongly recommended before testing. This test should be interpreted within the full clinical context, not in isolation.”
⚠️ Important Safety Notice:
- Exclusion Criteria: Patients with active infection or acute neurological deterioration unresponsive to standard management should not delay emergency care for genetic testing.
- Emergency Red Flags: Sudden onset of severe headache, seizures, loss of consciousness, or signs of increased intracranial pressure warrant immediate hospital evaluation—do not wait for genetic results.
- Medication Warning: Do not discontinue prescribed medication (e.g., antiepileptics, psychotropic drugs) without consulting your doctor. Genetic testing does not replace clinical management.
- Paediatric Testing: In compliance with UAE CDS Law 2026, genetic testing on minors requires prior genetic counselling and guardian consent.
Frequently Asked Questions
1. What does the TREM2 genetic test detect and who should consider it?
Answer: It identifies disease-causing mutations in TREM2 gene for early diagnosis of Nasu-Hakola disease. Neurologists, medical geneticists, and orthopaedic specialists may order it when clinical and radiological findings suggest this rare condition.
2. هل يمكن استخدام بطاقة FTA لنقل العينة؟
الإجابة: نعم، يمكن استخدام قطرة دم واحدة على بطاقة FTA، مما يسهل التجميع المنزلي الآمن عبر خدمة سحب الدم المتنقلة.
3. How long do results take and will insurance cover the in UAE?
Answer: Results are ready in 3–4 weeks, and your insurance coverage is verified for DHA-approved plans. Our billing team provides pre‑authorisation via WhatsApp.
Facility License: 9834453 | ISO 9001:2015 Cert: INT/EGQ/2509DA/3139
Accredited by DHA/MOHAP. All services comply with Federal Decree-Law No. 41 of 2024 (Health Data), UAE CDS Law 2026 for minors, and UAE PDPL.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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