Test Price
2,800 AED✅ Home Collection Available
TGM6 Gene Sequencing Test for Spinocerebellar Ataxia Type 35 (SCA35) – Autosomal Dominant – Dubai, UAE
Executive Summary & Core Metrics
Executive Summary
- Accuracy: 99.9% diagnostic sensitivity via ISO‑certified NGS with full Sanger confirmation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (daily 8 AM–11 PM).
- Clinical Guidance: Telephonic post‑test genetic counselling included.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) test analyzes the entire coding region of the TGM6 gene to detect pathogenic variants responsible for spinocerebellar ataxia type 35 (SCA35), an autosomal dominant neurodegenerative disorder. Sanger sequencing confirms all pathogenic findings.
| Feature | Our Test (TGM6 NGS) | Closest Alternative (Multi‑Gene Ataxia Panel) |
|---|---|---|
| Precision | Single‑gene deep sequencing with >99% analytical sensitivity | Broad coverage but may miss deep intronic variants in TGM6 |
| Methodology | NGS (Illumina) + Sanger confirmation | Whole Exome Sequencing / panel‑based NGS |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (often requires reflex to single‑gene testing) |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I understand the emotional weight of hereditary ataxia testing. This TGM6 sequencing test provides definitive molecular confirmation, enabling precise prognosis and informed family planning. Always correlate with a complete clinical and pedigree evaluation."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory – Medication Continuation
Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Genetic test results are intended to complement clinical management, not replace it.
Exclusion Criteria & Red Flags
- Exclusion Criteria: Acute encephalopathy or uncontrolled seizures interfering with informed consent; inability to provide a blood sample.
- ER Red Flags (this test is not for acute diagnosis): Rapidly worsening ataxia with loss of independent ambulation within weeks, new‑onset dysphagia with aspiration risk, acute vision loss, severe headache, or altered consciousness.
Patient FAQ & Clinical Guidance
1. What is the TGM6 gene test for SCA35?
The TGM6 sequencing test detects pathogenic variants in the TGM6 gene causing spinocerebellar ataxia type 35, an autosomal dominant disorder.
2. How should I prepare for the test?
Provide a detailed clinical history of ataxia symptoms and neurological examination findings; genetic counselling with a pedigree chart is required before sample collection.
3. Can the test be used for prenatal or predictive testing?
Yes, after thorough genetic counselling and informed consent, it can be applied in predictive or prenatal settings following UAE genetic testing regulations.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring patient data privacy and security.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing health data exchange and ICT use.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – regulating clinical safety and patient consent.
Clinical & Logistical Metadata
| Test Name | TGM6 Gene Sequencing (Spinocerebellar Ataxia Type 35) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA) – VIP Mobile Phlebotomy & Cold‑Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (Illumina) + Sanger Confirmation |
| ICD‑10‑CM Code | G11.8 (Other hereditary ataxias) |
| LOINC Code | 55233-1 (Genetic analysis) |
| DHA Facility License & Address | License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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