Test Price
2,800 AED✅ Home Collection Available
L1CAM (SPG1) Gene Sequencing Test in UAE | 2800 AED | DHA-Licensed Genetic Diagnostics
Executive Summary & Core Metrics
✅ Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 15189 & 9001:2015 Accredited NGS Processing.
🏥 Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily 8 AM to 11 PM.
📞 Clinical Guidance
Telephonic Post-Test Clinical Guidance in Result Interpretation by DHA-Licensed Specialist in Medical Genetics.
💳 Insurance Support
Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The L1CAM (SPG1) Gene Sequencing Test utilises Next-Generation Sequencing (NGS) to detect pathogenic variants in the L1CAM gene responsible for X-linked hereditary spastic paraplegia type 1 (SPG1). This test is essential for confirming a clinical diagnosis, guiding targeted neurological management, and enabling informed family genetic counselling. Complete coding region coverage includes ±20 bp intronic flanks with validated bioinformatics pipeline aligned to GRCh38.
| Feature | Our Test (NGS Sequencing) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Precision | High-depth NGS; covers entire coding region ±20 bp intronic flanks; variant allele frequency ≥ 30% | Limited to selected exons; may miss deep intronic or copy-number variants |
| Method | Illumina® NovaSeq™ platform with custom capture, validated bioinformatics pipeline (GRCh38) | Exonic Sanger sequencing, gold-standard but low throughput |
| Turnaround | 3 – 4 Weeks from sample receipt | Often 4 – 6 Weeks due to sequential exon walk |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant in Medical Genetics, I emphasise that a positive L1CAM result must be interpreted alongside neuroimaging, developmental milestones, and a detailed family pedigree. Spastic paraplegia type 1 demonstrates variable expressivity; therefore, a negative result does not entirely exclude atypical presentations. Always engage in pre- and post-test genetic counselling before making any reproductive or clinical management decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Medication Guidance
⚠ Important: Do not discontinue prescribed medications such as baclofen or tizanidine without consulting your treating physician. Genetic results provide diagnostic clarity but do not replace pharmacological treatment or ongoing neurological care.
Patient Safety Exclusion Criteria & Red Flags
- Recent blood transfusion (within 4 weeks) or allogeneic bone marrow transplant may cause sample chimerism.
- Inadequate sample: clotted whole blood, insufficient saliva/DNA, or FTA card not properly dried.
- Red Flags requiring immediate clinical review: sudden worsening of spasticity, new-onset seizures, or respiratory distress in an infant with suspected SPG1.
Patient FAQ & Clinical Guidance
1. How accurate is the L1CAM gene test for confirming SPG1?
The test achieves 99.9% diagnostic sensitivity for single-nucleotide variants and small indels within the L1CAM coding region, cross-validated against ClinVar and HGMD Professional databases. A negative result significantly reduces the likelihood of SPG1 but does not rule out atypical splicing or deep intronic mutations; further family studies or whole-genome sequencing may be considered.
2. Can I use my health insurance to cover the 2800 AED cost?
Many UAE insurers reimburse this test when a DHA-approved neurologist or clinical geneticist orders it with a pre-authorisation code. DNA Labs UAE offers direct billing verification through a dedicated WhatsApp number, and our team handles the insurance approval process on your behalf. Contact our support for an instant eligibility check.
3. What pre-test information or preparations are required before sample collection?
A mandatory genetic counselling session is required prior to sample collection. Our counsellor will draw a detailed four-generation pedigree chart and review your clinical history to ensure the correct test for your family. No fasting is necessary; a single blood tube (3 ml EDTA) or a dried blood spot card is sufficient.
4. Who will interpret my results and how will they be communicated?
A DHA-licensed Consultant Medical Genetics reviews and signs off every report. Results are communicated via a secure confidential portal and discussed during a scheduled telephonic or in-person genetic counselling session to ensure you fully understand the implications for your health and family members.
UAE Regulatory & Data Privacy Adherence
🇦🇪 Federal Decree-Law No. 45 of 2021 (PDPL)
All patient genetic data is encrypted at rest and in transit, stored exclusively on UAE-based servers, and never shared without explicit written consent, in full compliance with the Personal Data Protection Law.
🩺 Federal Law No. 2 of 2019 (Health ICT)
This law governs the use of information and communication technology in health fields, ensuring that all digital health data, including genetic test results, are handled with the highest standards of security and confidentiality.
⚖️ Federal Decree-Law No. 4 of 2016 (Medical Liability)
Clinical testing safety and patient consent protocols strictly follow this law, ensuring that every genetic test is ordered with informed consent and that results are used solely for direct clinical management.
📜 ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
Our laboratory is accredited under the ISO 9001:2015 quality management system, ensuring consistent process control and continual improvement across all diagnostic workflows.
🔬 DHA & Ministry of Health Oversight
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to all UAE federal regulations governing genetic testing, including mandatory pre-test genetic counselling and prohibitions on non-consensual disclosure of genetic information.
Clinical & Logistical Metadata
| Test Name | L1CAM (SPG1) Gene Sequencing Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks from sample receipt |
| Sample Type / Matrix | Whole Blood (3 ml EDTA) or Dried Blood Spot (FTA card) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq™ with custom capture |
| ICD-10-CM Code | G11.4, Z13.71, Z15.89 |
| LOINC Code | 101182-8 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians