Test Price
2,800 AED✅ Home Collection Available
HSD17B10 Gene (X‑Linked Mental Retardation Type 17 / HSD10 Disease) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين HSD17B10 (التخلف العقلي المرتبط بالكروموسوم X النوع 17 / مرض HSD10) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Clinical Privileges
- ✓ Diagnostic Sensitivity: 99.9% analytical sensitivity for single nucleotide variants and indels, validated by ISO 15189:2022 gold-standard NGS pipeline.
- ✓ Premium Logistics: Paid hospital‑grade home collection via ISO‑certified cold‑chain transportation; VIP mobile phlebotomy at your doorstep (8 AM‑11 PM).
- ✓ Clinical Guidance: Complimentary 15‑minute telephonic post‑test interpretation with a DHA‑licensed genetic counselor.
- ✓ Insurance Assistance: Direct billing verification via WhatsApp at +971 54 548 8731 (reply within 1 hour).
ملخص تنفيذي
يضمن هذا الفحص الجيني المتقدم القائم على تقنية تسلسل الجيل التالي (NGS) لجين HSD17B10 تشخيصًا دقيقًا بنسبة 99.9% لحساسية الطفرات المسببة للتخلف العقلي المرتبط بالكروموسوم X (النوع 17) ومرض HSD10 الاستقلابي، مع خدمة سحب منزلي متميزة واستشارة وراثية مهنية معتمدة من هيئة الصحة بدبي. للتحقق من التغطية التأمينية، يُرجى التواصل عبر الواتساب على الرقم +971 54 548 8731.
UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) · CDS Law 2026 (Minor Consent) · UAE PDPL Data Protection · ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) · DHA Facility License 9834453
Test Overview & Technology Comparison
The HSD17B10 (HADH2) gene encodes 17‑beta‑hydroxysteroid dehydrogenase 10, a mitochondrial enzyme critical for isoleucine metabolism and neurodevelopment. Pathogenic variants cause X‑linked mental retardation type 17 (MRX17) / HSD10 disease, presenting with intellectual disability, choreoathetosis, and neurodegeneration. Our NGS‑based test covers the entire gene with unmatched precision, enabling definitive molecular diagnosis.
| Feature | GENOS UAE NGS Test | Sanger Sequencing (Single Gene) | Whole Exome Sequencing |
|---|---|---|---|
| Method | Next‑Generation Sequencing (NovaSeq) | Capillary electrophoresis | NGS with exome capture |
| Diagnostic Sensitivity | 99.9% | ~95% (limited to targeted exons) | ~98% (coverage gaps possible) |
| Turnaround Time | 3–4 weeks | 4–6 weeks | 6–8 weeks |
| Intronic Variant Detection | Deep intronic (≥10 bp) | Not covered | Limited |
| Clinical Report | ACMG‑classified, family‑correlated | Basic variant call | Broad, may require reanalysis |
Physician Insight & Safety Protocol
“As the Clinical Pathologist overseeing genetic diagnostics, I must emphasise that while this NGS test detects HSD17B10 mutations with the highest technical confidence, the final diagnosis must be integrated with thorough neurological and metabolic evaluation. I strongly encourage families to work closely with their pediatric neurologist and geneticist to interpret the result in the context of the child’s unique clinical picture.” — Dr. Prabhakar Reddy, DHA License 61713011
⚠️ Medication Warning
Do not discontinue prescribed medication or supplements without consulting your doctor. Genetic results are diagnostic, not prescriptive; treatment changes must be made under specialist supervision.
Patient Safety – Exclusion Criteria & Red Flags
- 🚫 Inability to consent: Test requires signed informed consent from a legal guardian for minors, in full compliance with CDS Law 2026 (Dubai). Verbal assent not accepted.
- 🚫 Acute medical instability: Patients currently hospitalised with uncontrolled seizures, metabolic crises, or respiratory distress should not undergo elective venipuncture.
- 🚨 Emergency red flags: Seek immediate medical attention if you notice sudden loss of developmental milestones, prolonged seizures, severe lethargy, or vomiting suggestive of metabolic acidosis.
Patient FAQ & Virtual Genetic Guidance
What does the HSD17B10 NGS test diagnose?
This NGS assay identifies pathogenic mutations in the HSD17B10 gene responsible for X‑linked mental retardation type 17, HSD10 mitochondrial disease, and related neurodegeneration.
يحدد هذا التحليل الطفرات المرضية في جين HSD17B10 المسببة للتخلف العقلي المرتبط بالكروموسوم X من النوع 17 ومرض الميتوكوندريا HSD10 والأعراض العصبية المصاحبة.
How accurate is the Genetic Test for MRX17 / HSD10 disease?
The achieves 99.9% diagnostic sensitivity for single nucleotide changes and small insertions/deletions, validated through ISO‑15189 accredited bioinformatics and orthogonal confirmation.
تصل حساسية هذا الاختبار التشخيصية إلى 99.9% للتغيرات النوكليوتيدية المفردة والحذف/الإدراج الصغير، معتمدة عبر معلوماتية حيوية معززة وطرق تحقق متعامدة.
What sample is needed and how long do results take?
A simple blood draw (or one drop on FTA card) is collected at your home by a DHA‑licensed phlebotomist, and the final genetic report is ready in 3–4 weeks.
يتم سحب عينة دم بسيطة (أو قطرة واحدة على بطاقة FTA) في منزلك بواسطة مسعف مرخص، ويكون التقرير الجيني النهائي جاهزًا خلال 3–4 أسابيع.
Licensed genetic testing · ISO accredited · DHA‑governed service
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians