Test Price
2,800 AED✅ Home Collection Available
FLRT1 Genetic Testing (SPG68) in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation by a Consultant Medical Geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FLRT1 genetic test utilizes next-generation sequencing (NGS) to analyze all coding exons and flanking intronic regions of the FLRT1 gene, associated with autosomal recessive spastic paraplegia type 68 (SPG68). This high-resolution assay is essential for confirming a clinical diagnosis, guiding neurological management, and informing family planning decisions.
Targeted NGS with orthogonal Sanger confirmation of all identified variants ensures 99.9% analytical sensitivity and specificity. The test detects point mutations, small insertions or deletions, and copy number variations within the FLRT1 gene, providing definitive molecular results for individuals presenting with progressive lower-limb spasticity and a suspected hereditary aetiology.
| Feature | Our Test (FLRT1 NGS) | Standard HSP Panel |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity for FLRT1 | May include FLRT1 but with lower depth; not guaranteed full exon coverage |
| Methodology | Targeted NGS with Sanger confirmation of all variants | Multiplex panel NGS; confirmatory sequencing often omitted |
| Speed (TAT) | 3–4 Weeks | 4–8 Weeks (high-volume reference lab delays) |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I recognise the complex clinical and emotional considerations that accompany hereditary spastic paraplegia testing. A confirmed pathogenic FLRT1 variant demands careful neurological correlation and detailed family history review; a negative result does not exclude other genetic causes and may warrant further investigation. My role is to support you through each step of interpretation and counselling."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory – Medication and Clinical Precautions
Important Safety Advisory
DO NOT DISCONTINUE OR ALTER ANY PRESCRIBED MEDICATION WITHOUT CONSULTING YOUR TREATING PHYSICIAN.
If you are on anticoagulant therapy, discuss the need for a temporary pause 24 hours prior to blood collection with your doctor. Maintain normal hydration and inform our phlebotomist of any active infections or bleeding concerns before the procedure.
Patient Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Individuals under 18 years without a legally authorised guardian providing informed written consent.
- Active systemic infection or uncontrolled bleeding disorder that cannot be safely managed prior to venipuncture.
- Inability to safely pause anticoagulant medication for the required window before blood draw (only if clinically permissible).
Emergency Red Flags – Seek Immediate Care
- Sudden severe headache, vision loss, or rapidly worsening muscle weakness – go to the nearest emergency department.
- New-onset seizures, loss of consciousness, or acute confusion – call 998 or visit the closest ER without delay.
Patient FAQ & Clinical Guidance
1. What is the FLRT1 gene test for SPG68?
This NGS test identifies pathogenic variants in the FLRT1 gene responsible for SPG68, a form of hereditary spastic paraplegia.
The assay sequences all coding exons and flanking regions of FLRT1, detecting point mutations, small insertions or deletions, and copy number changes that cause autosomal recessive SPG68. It is recommended for individuals with progressive lower-limb spasticity and a suspected genetic origin, particularly when family history supports recessive inheritance.
2. How is the sample collected and what are the pre-test requirements?
A whole blood sample or extracted DNA is collected via VIP mobile phlebotomy; a mandatory pre-test genetic counselling session is required.
Our trained phlebotomist visits your home within an ISO-certified cold-chain transport framework. Before sampling, you must complete a genetic counselling session to document a three-generation pedigree and review relevant family history. Avoid non-essential supplementation for 48 hours beforehand and maintain normal hydration.
3. What is the turnaround time and how will I receive my results?
Results are ready in 3 to 4 weeks, delivered via encrypted email followed by a telephonic clinical guidance session.
The final report includes detailed variant interpretation, clinical correlation notes, and family screening recommendations. Our Consultant Medical Geneticist will call you to explain the findings, answer your questions, and coordinate any necessary follow-up with your neurologist.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is processed, stored, and transmitted under strict PDPL safeguards, ensuring your personal and clinical information remains confidential and protected.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Our digital health infrastructure complies fully with this law, governing the secure handling of electronic medical records and telemedicine communications.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: All clinical procedures, including genetic counselling and sample collection, adhere to the standards of medical liability defined under this decree, safeguarding patient rights and clinical accountability.
Clinical & Logistical Metadata
| Test Name | FLRT1 Genetic Testing (SPG68) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks (21–28 Days) |
| Sample Type / Matrix | Whole Blood or Extracted DNA |
| Methodology Used | Targeted NGS with Sanger Confirmation |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians