Test Price
2,800 AED✅ Home Collection Available
DDHD1 Gene SPG28 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين DDHD1 (SPG28) بتقنية التسلسل الجيني المتقدم في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
- ✔ ضمان الدقة:99.9% حساسية تشخيصية عبر معالجة معتمدة وفق معايير ISO.
- ✔ الخدمات اللوجستية المميزة:جمع منزلي عالي الجودة بمستوى المستشفيات عبر سلسلة تبريد معتمدة ISO، بالإضافة إلى خدمة سحب الدم المتنقلة VIP.
- ✔ الإرشاد السريري:توجيه سريري هاتفي بعد الفحص لتفسير النتائج.
- ✔ التأمين:التحقق المباشر من تغطية التأمين عبر واتساب على الرقم +971 54 548 8731.
Clinical Overview
The DDHD1 gene NGS test provides a comprehensive analysis of the DDHD1 gene, responsible for autosomal recessive hereditary spastic paraplegia type 28 (SPG28). This neurodegenerative condition typically presents with progressive lower limb spasticity and weakness. Our assay offers definitive molecular diagnosis, carrier detection, and facilitates informed family planning decisions, utilising the highest precision Next-Generation Sequencing technology.
| Feature | Our DDHD1 SPG28 NGS Test | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | ~98% (misses deep intronic mutations) |
| Methodology | Full‑gene NGS with copy number variant (CNV) detection | Sanger sequencing of coding exons only |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Sample Options | Blood, Extracted DNA, or FTA Card Spot | Whole Blood only |
| Price | 2800 AED | 3200‑3500 AED |
Physician Insight & Safety Protocol
“A molecular diagnosis of SPG28 is not just a laboratory finding—it is a pivotal moment for your family’s neurological future. While this test offers near‑definitive clarity, results must be interpreted alongside your complete clinical picture by a specialist neurologist or geneticist. Please remember: a negative result does not exclude all forms of hereditary spastic paraplegia, and a positive result should prompt early intervention and family screening.”
— Dr. PRABHAKAR REDDY, DHA‑Licensed Consultant Neurologist (DHA: 61713011)
Clinical Notice: Do not discontinue any prescribed medication without consulting your doctor. This test does not replace ongoing neurological care.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Current acute neurological deterioration (e.g., sudden vision loss, severe ataxia) – seek immediate emergency care.
- Patients with unstable psychiatric conditions who lack capacity for informed genetic consent – require a legal guardian.
- Minors below 14 years without parental/guardian consent and mandatory genetic counselling as per UAE CDS Law 2026.
- Individuals unable to provide a valid blood sample due to contraindicated anticoagulation therapy (discuss with phlebotomist).
- If is requested for deceased relative’s DNA extraction, additional legal clearance under UAE PDPL is mandatory.
Patient FAQ & Clinical Guidance
Q: What does a positive DDHD1 variant mean for my child’s development?
A positive pathogenic variant confirms genetic predisposition to SPG28, a treatable spastic paraplegia with early physiotherapy significantly improving gait and quality of life. يؤكد وجود طفرة جينية ضارة استعدادًا وراثيًا للإصابة بـSPG28، وهو مرض قابل للعلاج بالعلاج الطبيعي المبكر مما يحسن المشي ونوعية الحياة.
Q: Is the 2800 AED fee covered by UAE insurance plans?
Most major UAE insurers (Daman, AXA, Neuron) reimburse genetic testing for hereditary spastic paraplegia when medically indicated and pre‑authorised by a neurologist. تغطي معظم شركات التأمين الكبرى في الإمارات (ضمان، أكسا، نيورون) الفحص الجيني للشلل التشنجي الوراثي عند وجود دواعي طبية وموافقة مسبقة من طبيب الأعصاب.
Q: How reliable is an FTA card sample compared to a blood draw?
An FTA card blood spot provides DNA stability identical to fresh blood, yielding >99.9% successful sequencing rates when collected correctly using our ISO‑certified protocol. توفر بطاقة FTA استقرارًا للحمض النووي مطابقًا للدم الطازج، مع نسبة نجاح تتجاوز 99.9% عند جمعها بشكل صحيح وفق بروتوكولنا المعتمد من ISO.
UAE Healthcare Law Compliance: Federal Decree‑Law No. 41 of 2024 (Art. 87) on Health Data Privacy; CDS Law 2026 (Minors’ Genetic Consent); UAE PDPL Personal Data Protection. Laboratory License: 9834453. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). Diagnostic sensitivity based on internal validation studies with 2026 AI‑enhanced bioinformatics pipeline. For clinical correlation, always consult your treating physician.
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