Test Price
2,800 AEDโ Home Collection Available
CRBN Gene Genetic Test for Autosomal Recessive Intellectual Disability Type 2 (MRT2) | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity achieved through ISO-compliant next-generation sequencing with Sanger confirmation.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across Dubai and the Northern Emirates.
- Clinical Guidance: Post-test telephonic consultation with a consultant medical geneticist to interpret results and discuss familial implications.
- Insurance Facilitation: Direct billing verification and prior authorization support via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This molecular genetic test employs next-generation sequencing (NGS) to analyze the complete coding region and splice-site boundaries of the CRBN gene. Pathogenic variants in CRBN cause autosomal recessive intellectual disability type 2 (MRT2), a neurodevelopmental disorder characterized by moderate to severe cognitive impairment, delayed speech and motor milestones, and variable behavioral features. Our validated pipeline delivers 99.9% analytical sensitivity and specificity, with all clinically significant variants confirmed by Sanger sequencing before reporting.
| Feature | Our NGS Test | Alternative (Sanger Sequencing) |
|---|---|---|
| Analytical Sensitivity | 99.9% | ~95% |
| Methodology | Next-Generation Sequencing with Sanger confirmation | Sanger sequencing only |
| Turnaround Time | 21โ28 days (3โ4 weeks) | 42โ56 days (6โ8 weeks) |
| Accreditation | ISO 9001:2015 (Certificate INT/EGQ/2509DA/3139) | Not guaranteed |
Physician Insight & Safety Protocols
โThe NGS-based analysis of the CRBN gene provides exceptional resolution for detecting pathogenic variants responsible for autosomal recessive intellectual disability type 2. However, a negative result does not rule out other genetic or environmental contributors to the clinical phenotype. All findings must be correlated with the patientโs developmental history, neurological examination, and family pedigree. I strongly recommend a post-test genetic counseling session to fully contextualize the results and guide reproductive or management decisions.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory: Pre-Test Clinical Requirements
A thorough clinical history and a formal genetic counseling session to construct a three-generation pedigree chart documenting all family members affected with CRBN-related intellectual disability are mandatory prior to sample collection. Patients must avoid blood transfusions for at least two weeks before phlebotomy to prevent donor DNA contamination.
Exclusion Criteria & Emergency Indicators
- Exclusion Criteria: Active skin infection or rash at the venipuncture site, uncorrected severe bleeding disorder without medical clearance, and receipt of a blood transfusion within the preceding 14 days.
- Post-Collection Emergency Signs: Persistent hemorrhage from the puncture site, syncope or presyncope, and signs of anaphylaxis. Seek immediate emergency medical care if any of these occur.
Patient FAQ & Clinical Guidance
1. What is the CRBN gene test for autosomal recessive intellectual disability type 2?
This test uses next-generation sequencing to read the entire coding region of the CRBN gene and detect disease-causing mutations. It is indicated for individuals with unexplained moderate to severe intellectual disability, especially those with a family history suggestive of autosomal recessive inheritance. The test confirms a clinical diagnosis, enables carrier testing for at-risk family members, and informs reproductive planning.
2. How is the sample collected and what is the turnaround time?
A certified phlebotomist collects a peripheral whole blood sample (2โ5 mL in an EDTA tube), extracted DNA, or a dried blood spot on an FTA card. Our VIP mobile phlebotomy service operates daily from 8 AM to 11 PM, including weekends and public holidays in Dubai. Results are reported within 21 to 28 calendar days from sample receipt at the laboratory.
3. Is this test covered by UAE health insurance?
Many UAE-based health insurers cover medically indicated genetic testing when ordered by a licensed specialist and preceded by a formal pre-authorization request. We provide direct billing verification and assistance with the authorization process via WhatsApp at +971 54 548 8731. Coverage varies by insurer and policy; we recommend verifying your specific plan details before scheduling a collection.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance: All patient data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Laboratory Accreditation: ISO 9001:2015 certified (Certificate No. INT/EGQ/2509DA/3139). Facility licensed by the Dubai Health Authority (DHA License No. 1143).
Patient Support: Test scheduling, insurance verification, and result inquiries are handled via WhatsApp at +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | CRBN Gene Sequencing for Autosomal Recessive Intellectual Disability Type 2 (MRT2) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21โ28 Days (3โ4 Weeks) |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot on FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | F78.9, Z14.8, Z84.8 |
| LOINC Code | 103354-1 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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