Test Price
2,800 AEDโ Home Collection Available
ARSI Gene SPG66 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This advanced genetic test decodes the ARSI gene to diagnose hereditary spastic paraplegia type 66 (SPG66), a progressive neurological disorder. The analysis uses Next-Generation Sequencing (NGS) under ISO 9001:2015 accreditation, delivering diagnostic sensitivity >99.9%. Services include DHA-licensed home phlebotomy with cold-chain logistics, post-test telephone counselling, and direct insurance verification.
Test Overview & Methodology
The ARSI SPG66 genetic test utilizes Next-Generation Sequencing (NGS) to provide full coverage of the ARSI gene. This technology detects pathogenic variants responsible for hereditary spastic paraplegia type 66 with high analytical sensitivity and specificity. The test is performed on peripheral whole blood collected in EDTA tubes.
| Feature | Our NGS Test (DHA-Certified) | Conventional Sequencing |
|---|---|---|
| Precision | >99.9% analytical sensitivity & specificity | Variable, often <98% for rare variants |
| Methodology | Next-Generation Sequencing (NGS) with full gene coverage | Sanger sequencing (targeted exons only) |
| Turnaround Time | 3โ4 weeks with clinical report | 6โ8 weeks typical |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I emphasize that interpreting ARSI variants requires correlation with the patient's clinical history and family pedigree. A positive result does not always confirm disease onset, and a negative result does not exclude other genetic causes. Always discuss findings with a neurologist or genetic counsellor." โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ Clinical Notice: Do not discontinue prescribed medication without consulting your doctor. Genetic test results inform long-term management but should never replace immediate medical advice.
Safety Exclusion Criteria & Red Flags
- Inability to provide informed consent (guardian required for minors as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Recent blood transfusion (<2 weeks) may interfere with DNA extraction from whole blood.
- Severe haemodynamic instability that precludes safe venipuncture.
- ER red flag: If you experience sudden worsening of muscle weakness, falls, or speech difficulties, visit the nearest emergency departmentโdo not wait for genetic results.
Patient FAQ & Clinical Guidance
1. What exactly does the ARSI gene test detect, and why is it important for UAE patients?
It identifies mutations in the ARSI gene that cause spastic paraplegia type 66, enabling early intervention and family risk assessmentโcrucial in consanguineous populations where recessive disorders are more prevalent.
2. How long do the results take, and will I receive a clinical report?
Results are delivered within 3 to 4 weeks with an interpretive clinical report listing variants, pathogenicity classification, and recommendations for neurological follow-up.
3. Is home sample collection available across all UAE emirates?
Yes, we provide DHA-licensed VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection services from 8 AM to 11 PM daily, covering Dubai, Abu Dhabi, Sharjah, and the Northern Emirates.
UAE Regulatory & Data Privacy Adherence
This genetic testing service complies with the following UAE federal laws and standards:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ safeguarding genetic and health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ regulating digital health records and telemedicine.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ governing informed consent and clinical safety.
The laboratory is ISO 9001:2015 certified (certificate: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | ARSI Gene SPG66 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 weeks (clinical report included) |
| Sample Type / Matrix | Peripheral whole blood (EDTA) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM โ 11 PM, daily) |
| Methodology Used | Next-Generation Sequencing (NGS) โ full ARSI gene coverage |
| ICD-10-CM Code | G11.4 (Hereditary spastic paraplegia) |
| LOINC Code | 95836-5 (ARSI gene mutation analysis) |
| DHA Facility License & Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians