Test Price
2,800 AED✅ Home Collection Available
ARHGEF9 Gene (Early Infantile Epileptic Encephalopathy Type 8) NGS Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ARHGEF9 للاعتلال الدماغي الصرعي الطفولي المبكر من النوع 8 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي
اختبار تسلسل الجين ARHGEF9 بدقة تشخيصية تبلغ 99.9% عبر مختبر معتمد ISO 9001:2015. خدمة جمع العينات منزلية (سلسلة تبريد معتمدة) وتفسير إكلينيكي عبر الهاتف بعد النتيجة. تحقق من تغطية التأمين عبر واتساب: +971 54 548 8731
Overview
The ARHGEF9 gene NGS test precisely identifies pathogenic variants linked to Early Infantile Epileptic Encephalopathy Type 8 (EIEE8), a severe neurodevelopmental disorder. This advanced sequencing analysis aids in definitive diagnosis, guides personalized antiepileptic therapy, and informs family recurrence risk. يُقدم هذا التحليل الجيني تشخيصًا دقيقًا لاعتلال الدماغ الصرعي الطفولي المبكر من النوع 8 باستخدام تقنية التسلسل من الجيل القادم.
| Feature | Our Test (NovaSeq NGS) | Whole Exome Sequencing (WES) |
|---|---|---|
| Precision | 100% coverage of ARHGEF9 coding exons ±10 bp, >30x depth | Broader scan, may miss deep intronic variants or have lower coverage for this gene |
| Methodology | NGS (Illumina NovaSeq) with bioinformatic pipeline tuned for EIEE8 | Exome capture, variable depth; often requires secondary targeted confirmation |
| TAT | 21–28 working days | 6–8 weeks (plus time for confirmatory Sanger if needed) |
| Clinical Interpretation | Dedicated EIEE8 report with ACMG classification and pharmacogenomic insights | Broad report, may lack focused paediatric epilepsy commentary |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy, Consultant Neurologist (DHA: 61713011): “As a clinician managing early-onset epileptic encephalopathies, I stress that this genetic result must be correlated with the child’s electroclinical phenotype. A positive finding confirms the aetiology but does not replace bedside assessment; a negative result does not exclude the diagnosis.”
Medication Safety Warning
Do not discontinue prescribed antiepileptic medication without consulting your doctor.
Abrupt withdrawal of antiseizure drugs can provoke severe breakthrough seizures or status epilepticus; any adjustment must be supervised by a specialist.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Acute febrile illness (temperature >38°C) at time of sample collection; uncooperative child unable to remain still for venipuncture; dried blood spots that are clotted, hemolyzed, or insufficient.
- ER Red Flags After Sample Collection: New onset unprovoked cluster seizures within 24 h of draw, prolonged lethargy, or signs of allergic reaction at puncture site with spreading redness or fever – seek immediate medical attention.
- Specimen Rejection: Improperly labelled tubes, samples >48 h old, or those not transported in approved cold-chain kit will be rejected and recollection arranged.
Patient FAQ & Clinical Guidance
1. What does the ARHGEF9 gene test detect and how accurate is it?
This test identifies single nucleotide variants, small insertions/deletions, and copy number changes in the ARHGEF9 gene with 99.9% sensitivity. It pinpoints the exact molecular cause of early infantile epileptic encephalopathy type 8, enabling targeted treatment decisions and accurate genetic counselling.
يكشف التحليل عن الطفرات المسببة للاعتلال الدماغي الصرعي من النوع 8 بدقة تصل إلى 99.9%، مما يوجه العلاج ويساعد العائلة.
2. How is the sample collected and is home collection available?
A certified phlebotomist visits your home from 8 AM to 11 PM to draw 2–3 mL of venous blood (or a painless finger prick for an FTA card). The sample is immediately placed in an ISO-validated cold chain and transported to our genetics lab.
نوفر خدمة جمع العينات في المنزل طوال أيام الأسبوع (8 صباحًا – 11 مساءً) مع سلسلة تبريد معتمدة لضمان جودة العينة.
3. Can I use insurance to cover the cost of this test?
We provide direct billing verification via WhatsApp at +971 54 548 8731; simply send your insurance card image and we confirm coverage within one hour. The fee is 2800 AED; many UAE insurers cover genetic testing for epilepsy when medically indicated.
تحقق من تغطية التأمين عبر واتساب على الرقم 971545488731+ – نرسل لك الموافقة خلال ساعة. رسوم الاختبار 2800 درهم إماراتي.
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Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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