Test Price
2,800 AED✅ Home Collection Available
WWOX Gene Spinocerebellar Ataxia Type 12, Autosomal Recessive Next‑Generation Sequencing (NGS) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
Precision Genetic Diagnosis
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary post‑test telephonic interpretation session with a DHA‑licensed medical genetics consultant.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731 – instant confirmation for most UAE networks.
Test Overview & Methodology
The WWOX gene (WW domain‑containing oxidoreductase) is critical for neuronal survival; biallelic pathogenic variants cause autosomal recessive spinocerebellar ataxia type 12 (SCAR12), a progressive neurodegenerative disorder. Our NGS assay targets all coding exons and intron‑exon boundaries with unmatched coverage, enabling identification of SNVs, indels, and copy number variants in a single workflow – a decisive upgrade over conventional Sanger sequencing.
| Parameter | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Illumina NovaSeq X Plus NGS | Capillary electrophoresis (Sanger) |
| Clinical Sensitivity (SNVs/indels) | 99.9% (with orthogonal confirmation) | ~90% (limited by amplicon design) |
| Copy Number Variants Detection | Included (bioinformatic CNV caller) | Not available; requires MLPA add‑on |
| Turnaround Time (TAT) | 3‑4 weeks | 4‑8 weeks (if reflex to NGS needed) |
Physician Insight & Safety Protocols
“This NGS test provides a definitive molecular diagnosis for SCAR12, but the results must be interpreted in the full context of the patient's clinical presentation, family history, and neurological examination. The identification of a pathogenic variant empowers families with actionable information, yet it does not replace ongoing specialist care. Always correlate findings with your treating neurologist or medical geneticist.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Medication & Safety Advisory
Do not discontinue, modify, or skip any prescribed medication based on this test result without explicit advice from your treating physician. Abrupt cessation of anti‑epileptics, baclofen, or other neuro‑modulators can provoke dangerous withdrawal seizures or rebound spasticity.
Exclusion Criteria & Emergency Red Flags
- Inability to provide written informed consent, or legal guardian refusal (mandatory for minors as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Recent allogeneic blood transfusion (<2 weeks) if whole blood is the submitted sample – use extracted DNA or buccal swab instead.
- Emergency Red Flags: Sudden‑onset severe ataxia, difficulty breathing, altered consciousness, or acute vision loss – proceed to the nearest emergency department immediately.
- Red Flag: Post‑test result showing a pathogenic variant – schedule an urgent neurology follow‑up; do not delay.
Patient FAQ & Clinical Guidance
1. What is the WWOX gene and its role in Spinocerebellar Ataxia Type 12, autosomal recessive?
A: WWOX gene mutations cause autosomal recessive spinocerebellar ataxia 12 (SCAR12), a progressive neurodegenerative disorder characterised by cerebellar ataxia, dysarthria, and nystagmus. This test identifies pathogenic variants that confirm the clinical diagnosis and guide family risk assessment.
2. How accurate is the NGS test for WWOX gene sequencing?
A: Our NGS test achieves 99.9% diagnostic sensitivity for single nucleotide variants and small indels across the entire WWOX coding region, verified by an ISO 9001:2015‑certified laboratory with orthogonal confirmation of clinically significant findings.
3. Do I need a doctor’s referral to take this test in the UAE?
A: A referral from a neurologist or medical geneticist is recommended but not mandatory; we provide a mandatory genetic counselling session to ensure proper pre‑test education and post‑test interpretation.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Framework
- Licensed by DHA under Facility License Number: 1143.
- Operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genomic data stored on encrypted, UAE‑based servers.
- Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure processing of medical data.
- Clinical safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified (Cert. INT/EGQ/2509DA/3139) – covering sample collection, NGS laboratory workflow, and reporting.
Clinical & Logistical Metadata
| Test Name | WWOX Gene Spinocerebellar Ataxia Type 12, Autosomal Recessive Next‑Generation Sequencing (NGS) Genetic Test |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3‑4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Serum, or Plasma – VIP Mobile Phlebotomy Available |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina NovaSeq X Plus |
| G11.8 – Other hereditary ataxias; Z15.09 – Genetic susceptibility to other disease; Z13.71 – Encounter for screening for genetic disorders | |
| 81658‑3 – WWOX gene targeted mutation analysis by Sequencing | |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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