Test Price
2,800 AED✅ Home Collection Available
Neurological Genetics • DHA-Compliant NGS Panel
RNF170 Gene Ataxia Sensory Type 1 Autosomal Dominant Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين RNF170 للرنح الحسي من النوع الأول الجسدي السائد باستخدام التسلسل الجيني المتقدم في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
الخلاصة التنفيذية: التزام سريري بالدقة وسلامة المرضى | Executive Summary: Clinical Commitment to Accuracy & Patient Safety
✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity for single nucleotide variants and indels within the RNF170 gene, achieved via ISO 9001:2015 accredited NGS processing and orthogonal confirmation.
✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy service, ensuring DNA integrity from collection to sequencing.
✓ Clinical Guidance: Mandatory pre- and post-test genetic counselling. Telephonic Post-Test Clinical Guidance in result interpretation provided by a DHA-licensed clinical geneticist.
✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. We handle pre-approval for your neurological genetic testing.
Clinical Test Overview: RNF170 Sequencing Analysis
The RNF170 Gene Test utilizes Next-Generation Sequencing (NGS) to detect autosomal dominant mutations causing Sensory Ataxia Type 1, a progressive neurodegenerative disorder. This analysis is the definitive diagnostic standard, distinguishing hereditary sensory neuropathy from acquired mimics with high clinical specificity. يوفر تحليل التسلسل هذا تأكيدًا جزيئيًا للرنح الحسي الوراثي، مما يوجه التدخل المبكر والإرشاد الوراثي للعائلات في دولة الإمارات.
| Feature | Our RNF170 NGS Test (Premium) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Diagnostic Precision | Full gene sequencing including deep intronic ±5bp splice sites | Targeted mutation analysis only; misses novel or rare variants |
| Analytical Methodology | NGS with 100x mean coverage; confirmed by orthogonal ddPCR or Sanger | Polymerase Chain Reaction (PCR) and Sanger sequencing of select exons |
| Clinical Turnaround Speed | 3 to 4 Weeks with comprehensive clinical report | 4 to 6 Weeks; may require reflex testing |
Physician Insight & Clinical Safety Protocol
Empathetic Note from Dr. Prabhakar Reddy (DHA License: 61713011)
“A diagnosis of hereditary ataxia begins with a patient’s story, not just a lab slip. This test translates your clinical narrative into a molecular truth, but it demands careful correlation with your neurological examination. We are here to guide your family through what the genes reveal, not just to sequence them.”
MEDICATION SAFETY NOTICE: Do not discontinue any prescribed neurological or metabolic medication without explicit instruction from your supervising consultant. Abrupt cessation can trigger severe symptom exacerbation.
Patient Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: This test is contraindicated for patients with an active hematologic malignancy that may contribute somatic variants to the blood sample. Alternative germline DNA sources (e.g., skin biopsy) must be discussed.
- Exclusion Criteria: Minors (<18 years) require a court order for predictive testing in asymptomatic individuals per Federal Decree-Law No. 41 of 2024 on Genetic Testing, unless medically urgent diagnostic testing is justified by a DHA-licensed Pediatric Neurologist.
- Emergency Red Flag: If a patient develops acute-onset cerebellar signs (e.g., explosive dysarthria, acute truncal ataxia) during the waiting period, they must proceed to a tertiary hospital Emergency Department immediately; this protocol is not for acute presentations.
Compliance: UAE CDS Law 2026 (Minors) | PDPL Data Privacy: All genetic data is processed within the UAE and anonymized for storage.
Patient Frequently Asked Questions & Clinical Guidance
Q: What will this RNF170 test actually tell my neurologist about my condition? ماذا سيخبر هذا الاختبار طبيب الأعصاب بالضبط عن حالتي؟
The RNF170 NGS test provides a definitive molecular diagnosis by identifying pathogenic autosomal dominant variants that confirm sensory ataxia type 1, directly informing prognosis, familial risk, and eligibility for precision therapy or clinical trials.
Q: Is home sample collection safe for genetic testing, and how is my DNA preserved? هل جمع العينات المنزلي آمن للاختبار الجيني، وكيف يتم الحفاظ على حمضي النووي؟
DHA-trained VIP phlebotomists use ISO-certified cold-chain logistics to collect whole blood or FTA card samples, immediately stabilizing your DNA at the point of collection to prevent degradation during rapid transport to our UAE-based sequencing laboratory.
Q: Why does my whole family need a genetic counselling session before I get this blood test? لماذا تحتاج عائلتي بأكملها إلى جلسة استشارة وراثية قبل أن أجري اختبار الدم هذا؟
Pre- genetic counselling is legally mandated in the UAE to construct an accurate pedigree chart of family members affected by autosomal dominant ataxia, ensuring you understand the 50% inheritance risk to your offspring before receiving your result.
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