Test Price
2,800 AED✅ Home Collection Available
RNF170 Gene Ataxia Sensory Type 1 Autosomal Dominant Genetic Test in UAE | 2800 AED | DHA-Compliant NGS Panel
Executive Summary & Core Metrics
✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity for single nucleotide variants and indels within the RNF170 gene, achieved via ISO 9001:2015 accredited NGS processing and orthogonal confirmation.
✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM, ensuring DNA integrity from collection to sequencing.
✓ Clinical Guidance: Mandatory pre- and post-test genetic counselling. Telephonic Post-Test Clinical Guidance in result interpretation provided by a DHA-licensed clinical geneticist.
✓ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. We handle pre-approval for your neurological genetic testing.
Test Overview & Methodology
The RNF170 Gene Test utilizes Next-Generation Sequencing (NGS) to detect autosomal dominant mutations causing Sensory Ataxia Type 1, a progressive neurodegenerative disorder. This analysis is the definitive diagnostic standard, distinguishing hereditary sensory neuropathy from acquired mimics with high clinical specificity. Full gene sequencing includes deep intronic regions and flanking splice sites up to ±5 base pairs, ensuring comprehensive variant detection across the entire coding and regulatory landscape.
| Feature | Our RNF170 NGS Test (Premium) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Diagnostic Precision | Full gene sequencing including deep intronic ±5bp splice sites | Targeted mutation analysis only; misses novel or rare variants |
| Analytical Methodology | NGS with 100x mean coverage; confirmed by orthogonal ddPCR or Sanger | Polymerase Chain Reaction (PCR) and Sanger sequencing of select exons |
| Clinical Turnaround Speed | 3 to 4 Weeks with comprehensive clinical report | 4 to 6 Weeks; may require reflex testing |
Physician Insight & Safety Protocols
Empathetic Note from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA License: 9294403)
“A diagnosis of hereditary ataxia begins with a patient’s story, not just a lab slip. This test translates your clinical narrative into a molecular truth, but it demands careful correlation with your neurological examination. We are here to guide your family through what the genes reveal, not just to sequence them.”
Advisory: Medication Stability & Clinical Monitoring
MEDICATION SAFETY NOTICE: Do not discontinue any prescribed neurological or metabolic medication without explicit instruction from your supervising consultant. Abrupt cessation can trigger severe symptom exacerbation. Maintain a symptom diary and report any new or worsening neurological deficits to your managing physician immediately.
Exclusion Criteria & Emergency Referral Protocol
- Exclusion Criteria: This test is contraindicated for patients with an active hematologic malignancy that may contribute somatic variants to the blood sample. Alternative germline DNA sources (e.g., skin biopsy) must be discussed.
- Exclusion Criteria: Minors under 18 years require a court order for predictive testing in asymptomatic individuals per Federal Decree-Law No. 4 of 2016 on Medical Liability, unless medically urgent diagnostic testing is justified by a DHA-licensed Pediatric Neurologist.
- Emergency Red Flag: If a patient develops acute-onset cerebellar signs such as explosive dysarthria or acute truncal ataxia during the waiting period, they must proceed to a tertiary hospital Emergency Department immediately; this protocol is not for acute presentations.
Patient FAQ & Clinical Guidance
1. What will this RNF170 test actually tell my neurologist about my condition?
The RNF170 NGS test provides a definitive molecular diagnosis by identifying pathogenic autosomal dominant variants that confirm sensory ataxia type 1, directly informing prognosis, familial risk, and eligibility for precision therapy or clinical trials.
2. Is home sample collection safe for genetic testing, and how is my DNA preserved?
DHA-trained VIP phlebotomists use ISO-certified cold-chain logistics to collect whole blood or FTA card samples, immediately stabilizing your DNA at the point of collection to prevent degradation during rapid transport to our UAE-based sequencing laboratory.
3. Why does my whole family need a genetic counselling session before I get this blood test?
Pre- genetic counselling is legally mandated in the UAE to construct an accurate pedigree chart of family members affected by autosomal dominant ataxia, ensuring you understand the 50% inheritance risk to your offspring before receiving your result.
UAE Regulatory & Data Privacy Adherence
All genetic data generated by this test is processed exclusively within the UAE under the protections of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genomic information is anonymized at the point of sequencing, stored on encrypted UAE-based servers, and never shared with third parties without explicit written consent. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring your rights to informed decision-making and medical accountability are preserved at every stage of the testing pathway.
Clinical & Logistical Metadata
| Test Name | RNF170 Gene Ataxia Sensory Type 1 Autosomal Dominant Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card Sample |
| Methodology Used | Next-Generation Sequencing (NGS) with 100x Mean Coverage; Orthogonal Confirmation via ddPCR or Sanger Sequencing |
| ICD-10-CM Code | G60.0 |
| LOINC Code | 94233-3 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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