Test Price
2,800 AED✅ Home Collection Available
USP8 Gene NGS Test for Hereditary Spastic Paraplegia Type 59 (SPG59) in Dubai, UAE – 2,800 AED
Executive Summary & Core Metrics
Accuracy: 99.9% diagnostic sensitivity via ISO 15189 & ISO 9001:2015 accredited processing.
Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection (8 AM–11 PM daily).
Post‑Test Guidance: Telephonic counselling by a DHA‑licensed consultant medical geneticist.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next‑Generation Sequencing (NGS) test analyzes the entire coding region of the USP8 gene to detect single‑nucleotide variants, small indels, and copy‑number changes causative of Hereditary Spastic Paraplegia Type 59 (SPG59). The assay provides a definitive molecular diagnosis, enabling targeted neurology care, prognosis, and family screening. Orthogonal Sanger confirmation is performed on all reported variants.
| Parameter | Our USP8 NGS Test | Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% analytical sensitivity; uniform coverage >100× | ~98% per amplicon; prone to allele drop‑out |
| Method | NGS with orthogonal Sanger confirmation | Conventional Sanger sequencing of individual exons |
| Speed | 21–28 days from sample receipt | 4–6 weeks due to sequential processing |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I recognise the profound emotional weight of a genetic diagnosis. However, identifying a pathogenic USP8 variant through this NGS test provides clarity, enabling tailored rehabilitation strategies, eligibility for clinical trials, and informed family planning decisions. This test transforms uncertainty into actionable clinical insight.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic results must always be correlated with clinical findings.
Exclusion Criteria
- Acute febrile illness or active infection at time of collection
- Inability to provide informed consent (adults) or parental consent (minors per UAE Federal Law No. 2 of 2019)
- Whole‑blood transfusion within the last 30 days – may interfere with germline DNA analysis
Emergency Red Flags (seek immediate care)
- Sudden, severe worsening of gait or spasticity
- Acute visual loss or cranial nerve palsies
- New‑onset seizures or altered consciousness
Patient FAQ & Clinical Guidance
1. What is the clinical purpose of USP8 gene testing for SPG59?
This NGS test definitively diagnoses Hereditary Spastic Paraplegia Type 59 by identifying pathogenic USP8 variants, enabling targeted neurology care. It differentiates SPG59 from other causes of progressive lower‑limb spasticity and guides prognosis, treatment selection, and family screening.
2. How is the sample collected for this test in Dubai and across the UAE?
A hospital‑grade phlebotomist visits your home for a simple blood draw or fingertip FTA card collection, respecting UAE cold‑chain protocols. Whole blood (EDTA), extracted DNA, or a single drop on an FTA card is accepted. Samples are transported at 2–8°C to our ISO‑certified laboratory.
3. Why should I choose this DHA‑aligned genetic test over cheaper alternatives?
Our DHA‑compliant test provides 99.9% diagnostic sensitivity, post‑test telephonic geneticist counselling, and direct insurance verification — eliminating hidden costs. Alternative low‑cost tests often lack ISO 9001:2015 accreditation, do not include pre‑test genetic counselling, and cannot guarantee data privacy under UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
UAE Regulatory & Data Privacy Adherence
All patient data is stored and processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our ISO 9001:2015 certified management system ensures continuous adherence to these frameworks.
Clinical & Logistical Metadata
| Test Name | USP8 Gene NGS for Hereditary Spastic Paraplegia Type 59 (SPG59) |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 days from sample receipt |
| Sample Type / Matrix | Whole Blood (EDTA) or DNA (extracted) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians