Test Price
2,800 AED✅ Home Collection Available
TECPR2 Gene SPG49 Genetic Test in Dubai | 2,800 AED | Next-Generation Sequencing
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% via Next‑Generation Sequencing with ISO 9001:2015‑certified processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection, available daily from 8 AM to 11 PM.
- Integrated Genetic Counseling: Post‑test telephonic consultation with a Consultant Medical Geneticist for result interpretation.
- Insurance & Billing: Direct coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The TECPR2 Gene SPG49 Genetic Test uses next‑generation sequencing (NGS) to detect pathogenic variants in the TECPR2 gene, confirming autosomal recessive spastic paraplegia type 49 (SPG49) with 99.9% diagnostic sensitivity. Full gene sequencing includes deep intronic regions and copy‑number variant (CNV) detection, providing a molecular diagnosis that guides prognosis and family counseling.
| Feature | Our Test – TECPR2 NGS | Closest Alternative – Sanger Sequencing |
|---|---|---|
| Precision / Coverage | Full gene sequencing + deep intronic regions + CNV detection | Only coding exons; no copy‑number variant detection |
| Methodology | Next‑Generation Sequencing (Illumina®) with bioinformatic validation | Sanger capillary electrophoresis; reads individual amplicons |
| Turnaround Time | 3–4 weeks from sample receipt | 4–6 weeks; dependent on sequential amplicon analysis |
Pre‑Test Requirements & Genetic Counseling
- Clinical History: Provide comprehensive neurological history of the patient, including age of onset and progression.
- Genetic Counseling Session: Mandatory pre‑test genetic counselling to construct a pedigree chart of family members affected by TECPR2‑associated conditions.
- Informed Consent: Signed consent after thorough discussion of potential outcomes, limitations, and incidental findings in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Sample Collection Options: Blood draw, extracted DNA, or dried blood spot on an FTA card – performed by certified phlebotomist.
- Paediatric Compliance: For minors, guardian consent and mandatory child‑appropriate genetic counseling are required under UAE regulatory standards.
Physician Insight & Safety Protocols
“A definitive molecular diagnosis of SPG49 empowers families with accurate recurrence risk assessment and enables tailored supportive care. This NGS‑based test offers comprehensive coverage of the TECPR2 gene, minimizing diagnostic odyssey for patients presenting with progressive spastic paraplegia.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Important Clinical Advisory
Do not discontinue or modify any prescribed therapy without prior discussion with your treating physician. Genetic test results should be interpreted in conjunction with full clinical evaluation and neurological assessment.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Refusal of pre‑test genetic counseling; inability to provide valid informed consent; age under 18 without guardian consent per Federal Decree‑Law No. 4 of 2016 on Medical Liability; active coagulopathy or contraindication to venipuncture.
- Red Flags – Seek Immediate Medical Attention: Acute worsening of gait instability, rapid cognitive decline, new‑onset seizures, or signs of raised intracranial pressure (severe headache, vomiting).
- Data Privacy: All genetic data is handled under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of ICT in Health Fields; samples are coded and stored securely.
Patient FAQ & Clinical Guidance
1. What is the purpose of the TECPR2 SPG49 genetic test?
This test detects pathogenic mutations in TECPR2 to confirm autosomal recessive spastic paraplegia type 49, enabling definitive diagnosis and family counseling. It is the most accurate method to distinguish SPG49 from other hereditary spastic paraplegias, guiding prognosis and targeted management strategies.
2. How is the sample collected for this test?
A simple blood draw, extracted DNA, or a dried blood spot on an FTA card is all that is required for high‑quality sequencing. Our VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection service uses ISO‑certified logistics, and the procedure is quick and minimally invasive.
3. How long do results take and how are they interpreted?
Results are ready in 3–4 weeks and include a comprehensive report interpreted by a Consultant Medical Geneticist for prognostic guidance. We provide a telephonic consultation to explain the findings and their implications for you and at‑risk relatives.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance & Data Privacy
This test is performed at DNA Labs UAE, a DHA‑licensed facility (License No. 1143) operating in full compliance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring your genetic data is collected, processed, and stored with the highest privacy standards.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing secure digital health records and telemedicine practices.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – establishing the legal framework for informed consent and patient safety in clinical genetic testing.
Clinical & Logistical Metadata
| Test Name | TECPR2 Gene SPG49 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole blood, extracted DNA, or dried blood spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (Illumina®) with bioinformatic validation |
| ICD-10-CM Code | G11.4 (Hereditary spastic paraplegia), Z13.7 (Encounter for screening for genetic abnormalities), Z14.8 (Genetic carrier status) |
| LOINC Code | 69548-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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