Test Price
2,800 AED✅ Home Collection Available
TARDBP Gene Frontotemporal Dementia Genetic Test in UAE DHA Approved
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TARDBP Gene Frontotemporal Dementia Genetic Test detects pathogenic variants in the TARDBP gene linked to frontotemporal dementia and amyotrophic lateral sclerosis using Next-Generation Sequencing (NGS). This single-gene analysis provides comprehensive coverage of all coding exons and flanking intronic regions, enabling detection of single nucleotide variants, small insertions, and deletions with 99.9% analytical sensitivity.
| Feature | Our Test (TARDBP NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) | Sanger Sequencing |
| Analytical Sensitivity | 99.9% (detects single nucleotide, indels) | ~95% (limited regions) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), shares: “Genetic test results for TARDBP must always be interpreted alongside comprehensive clinical and family history to guide personalized care. This test can uncover risk, but a positive result does not guarantee disease onset; it empowers proactive surveillance. Pre-test genetic counseling is essential to construct a detailed pedigree and discuss implications for at-risk family members. If you experience sudden cognitive decline, muscle weakness, or speech difficulties, seek immediate medical evaluation.”
Advisory & Medication Guidance
Important Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic test results should never replace professional medical advice or alter ongoing treatment regimens without explicit physician approval.
Safety Exclusion Criteria & ER Red Flags
Exclusion Criteria
- Exclusion: Recent blood transfusion (<4 weeks) or bone marrow transplant — may affect genetic analysis.
- Exclusion: Acute febrile illness or active infection — reschedule after recovery.
- ER Red Flag: New-onset confusion, difficulty swallowing, breathing difficulty, or loss of consciousness — proceed to nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the TARDBP gene and its role in frontotemporal dementia?
The TARDBP gene encodes the TDP-43 protein, which regulates RNA processing. Pathogenic mutations in TARDBP cause TDP-43 proteinopathy, leading to frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This test identifies disease-causing variants to clarify diagnosis and guide family counseling.
2. How is this genetic test performed and what sample is required?
A standard venous blood sample is collected via VIP Mobile Phlebotomy at your home. Alternatively, extracted DNA or a single blood drop on an FTA card may be used. A pre-test genetic counseling session is required to draw a pedigree chart and discuss inheritance patterns before sample collection proceeds.
3. Can this test predict if I will definitely develop frontotemporal dementia?
A positive result indicates increased risk but not diagnostic certainty. Penetrance and age of onset vary widely even within families. Genetic counseling is essential for result interpretation, risk communication, and discussion of surveillance options. A negative result does not rule out non-genetic forms of FTD.
4. What is the turnaround time and how will I receive my results?
Turnaround time is 3 to 4 weeks from sample receipt. Results are reviewed and signed off by our Consultant Medical Genetics specialist, followed by a telephonic post-test clinical guidance session to explain findings, implications, and recommended next steps.
5. Does insurance cover this genetic test?
Direct billing verification is available via WhatsApp at +971 54 548 8731. Coverage depends on your insurance provider and policy terms. Our team will assist with pre-authorization documentation and claims support.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This genetic test is performed in strict compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, access-controlled, and processed within ISO-accredited laboratories. Results are shared only with the referring physician and the patient through secure channels.
Clinical & Logistical Metadata
| Test Name | TARDBP Gene Frontotemporal Dementia Genetic Test (NGS) |
| Price (AED) | 2,800 AED (incl. home collection & counseling) |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (venous), Extracted DNA, or FTA Card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – Full coding exons & flanking intronic regions |
| ICD-10-CM Code | G31.09 |
| LOINC Code | 92811-1 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians