Test Price
2,800 AED✅ Home Collection Available
NDUFAF3 Gene Leigh Syndrome Genetic Test in Dubai | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
✦ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
✦ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
✦ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
✦ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test utilises Next-Generation Sequencing (NGS) to analyse the NDUFAF3 gene for pathogenic variants associated with Leigh syndrome, a severe neurological disorder of mitochondrial origin. It provides definitive diagnostic confirmation, carrier status identification, and familial risk assessment with a turnaround time of 3–4 weeks. The assay is validated under ISO 9001:2015 and processed in our Dubai Healthcare City laboratory.
| Feature | Our Test: NDUFAF3 NGS | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Method | NGS targeted gene sequencing | Exome-wide capture & sequencing |
| Diagnostic Sensitivity for NDUFAF3 | 99.9% (validated variant detection) | ~95% (coverage gaps may miss variants) |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Price (AED) | 2,800 | 10,000+ |
| Clinical Relevance | Directly focused on NDUFAF3-related Leigh syndrome | Incidental findings may cause anxiety; broader but less specific |
Physician Insight & Safety Protocols
“Understanding the genetic basis of Leigh syndrome brings both clarity and responsibility. This targeted NDUFAF3 sequencing delivers high-confidence diagnostic evidence, yet it must always be interpreted alongside a complete neurological examination and delivered with thorough pre- and post-test genetic counselling.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Clinical Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic test results are not a substitute for ongoing clinical management.
Safety Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Inability to provide informed consent (mandatory parental consent for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability); active bleeding disorders or severe anaemia contraindicating blood draw; known hypersensitivity to antiseptics used in phlebotomy.
- ER Red Flags: If the patient develops acute neurological deterioration (e.g., seizures, loss of consciousness, respiratory distress), seek immediate emergency medical care rather than proceeding with elective genetic testing.
- Pre-test Requirement: A pre-test genetic counselling session is mandatory to document family pedigree and discuss implications. Sample collection: Whole blood (3–5 mL in EDTA tube) or one drop of blood on FTA card, or previously extracted DNA.
Patient FAQ & Clinical Guidance
1. What is the NDUFAF3 gene test and why is it performed?
NDUFAF3 gene testing identifies pathogenic variants that cause Leigh syndrome, a severe inherited mitochondrial neurological disorder. This analysis is essential for confirming a suspected diagnosis, guiding treatment decisions, and informing family planning. It helps differentiate Leigh syndrome from other mitochondrial or metabolic conditions that present with overlapping features such as developmental regression, movement disorders, and lactic acidosis.
2. How is the sample collected and what are the requirements?
Sample collection requires a simple blood draw or a finger-prick dried blood spot card performed by a certified phlebotomist. Our VIP mobile phlebotomy service arrives at your home between 8 AM and 11 PM, adhering to ISO-certified cold-chain transport. No special preparation such as fasting is required, but a mandatory pre-test genetic counselling session must be completed either in-clinic or via teleconsultation. A signed consent form is mandatory, particularly for minors, in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
3. How accurate is the test and will my insurance cover it?
The test achieves 99.9% diagnostic sensitivity for known NDUFAF3 pathogenic variants using next-generation sequencing technology and rigorous ISO 9001:2015 validation. Most UAE insurers recognise the medical necessity of genetic testing for suspected Leigh syndrome. We provide direct billing verification via WhatsApp at +971 54 548 8731 to confirm your coverage. The out-of-pocket cost is 2,800 AED, and we can assist with flexible payment plans if needed.
UAE Regulatory & Data Privacy Adherence
Data Protection & Confidentiality: All genetic data is stored exclusively within UAE borders and handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. This ensures that your genomic information remains secure and is never transferred outside the country.
Clinical Safety Framework: Patient consent, medical liability, and safety protocols governing sample collection and result disclosure operate under Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification (Cert. INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | NDUFAF3 Gene Leigh Syndrome Sequencing (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (3–5 mL in EDTA tube), dried blood spot on FTA card, or previously extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – targeted gene sequencing |
| ICD-10-CM Code | G31.82 |
| LOINC Code | 94038-6 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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