Test Price
2,800 AED✅ Home Collection Available
NDE1 Gene Lissencephaly Type 4 with Microcephaly Genetic Test in UAE | 2800 AED | DHA License 1143
Executive Summary & Core Metrics
✅ Accuracy Guarantee: >99.9% diagnostic sensitivity via ISO 15189 accredited next‑generation sequencing
🧪 Premium Logistics: VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection (daily 8 AM–11 PM)
👨⚕️ Clinical Guidance: Post‑test telephonic counselling with consultant medical geneticist
💰 Insurance: Direct billing verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
This genetic assay analyses the NDE1 gene using a robust next‑generation sequencing (NGS) panel that covers all coding exons and exon‑intron boundaries. It definitively detects disease‑causing mutations in lissencephaly type 4 with microcephaly, a severe neurodevelopmental disorder. The test provides a molecular diagnosis, informs recurrence risk, and guides targeted clinical management.
| Feature | Our Test (NDE1 NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Precision | >99.9% analytical sensitivity for all coding exons | ~95% sensitivity, limited to known hotspots |
| Method | Next‑generation sequencing (Illumina platform) | Capillary electrophoresis, single amplicon |
| Turnaround Time | 3–4 weeks | 5–7 weeks |
Physician Insight & Safety Protocols
“As a consultant in medical genetics caring for families affected by lissencephaly, I emphasise that this NGS test provides definitive diagnostic clarity. Results must always be interpreted alongside clinical findings, neuroimaging, and a detailed family pedigree. Please do not discontinue any prescribed medication without consulting your treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration: 9294403
⚠️ Medication Advisory
Do not discontinue any prescribed anti‑epileptic or neuroprotective medication without explicit instruction from your neurologist or geneticist.
Exclusion Criteria & Emergency Red Flags
Exclusion criteria for outpatient home collection:
- No clinical suspicion of lissencephaly or microcephaly without a prior genetic counselling referral
- Patient unable to provide informed consent (or guardian consent for minors)
🚨 Emergency red flags – seek immediate medical attention if:
- New‑onset seizures or prolonged seizure activity
- Severe respiratory distress or apnea
- Inability to feed or signs of dehydration in infants
Patient FAQ & Clinical Guidance
1. What is the NDE1 gene lissencephaly type 4 test?
This NGS test analyses the entire NDE1 gene to confirm disease‑causing mutations in lissencephaly type 4 with microcephaly. It detects point mutations, small deletions/insertions, and copy number variations, offering a definitive molecular diagnosis and informing recurrence risk for families.
2. How long does it take to receive my results?
The standard turnaround time is 3–4 weeks from receipt of a blood or DNA sample at our ISO‑accredited laboratory. Urgent prenatal or pre‑surgical cases can be expedited to 2–3 weeks after discussion with our genetic counselling team. Your referring physician receives the report via encrypted DHA‑compliant channels.
3. Is this genetic test covered by UAE health insurance?
Many UAE‑based insurers cover the test when a neurologist or clinical geneticist provides a letter of medical necessity and a pre‑authorisation code (ICD‑10 Q04.3, Q02, Z15.81). Our team offers free insurance verification via WhatsApp (+971 54 548 8731) before sample collection. If coverage is partial, the self‑pay price remains 2,800 AED.
UAE Regulatory & Data Privacy Adherence
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA License No. 1143). All patient data are processed in strict accordance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree‑Law No. 4 of 2016 on Medical Liability
Sample transport and storage comply with ISO 15189 standards and DHA cold‑chain regulations. Your genomic data remain confidential and are accessible only to the authorised clinical team.
Clinical & Logistical Metadata
| Test Name | NDE1 Gene Lissencephaly Type 4 with Microcephaly Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (expedited 2–3 weeks available for urgent cases) |
| Sample Type / Matrix | Peripheral whole blood (4 mL in EDTA tube) or extracted genomic DNA; VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection available daily 8 AM–11 PM |
| Methodology Used | Next‑generation sequencing (NGS) – Illumina platform, full coding exons ± 20 bp flanking intronic regions |
| ICD‑10‑CM Code | Q04.3, Q02, Z15.81 |
| LOINC Code | 100116-6 |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Laboratory: DNA Labs UAE |
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