Test Price
2,800 AED✅ Home Collection Available
ARHGEF9 Gene-Related Hyperekplexia & EIEE8 Genetic Test in UAE – 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM daily).
- Clinical Guidance: Telephonic Post-Test Result Interpretation by a DHA-Licensed Genetic Counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ARHGEF9 NGS test screens for pathogenic variants linked to hereditary hyperekplexia and early infantile epileptic encephalopathy type 8 (EIEE8). This test provides definitive molecular diagnosis for neurological disorders characterized by exaggerated startle responses and early-onset seizures, enabling personalized medical management and family risk assessment.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing Single Gene) |
|---|---|---|
| Precision | 99.9% analytical sensitivity for all coding regions and splice sites | ~95% sensitivity; may miss deep intronic or large deletions |
| Method | Next Generation Sequencing with copy number variant calling | Sanger sequencing, no copy number detection |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I guide families through the complexities of genetic testing for hyperekplexia and early infantile epileptic encephalopathies. This NGS panel offers high diagnostic yield, but careful pre-test counselling and post-test interpretation are crucial. All results must be correlated with clinical phenotype and EEG findings.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License 9294403.
Medication Advisory
⚠️ Do not discontinue prescribed anti-epileptic or sedative medications without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients currently hospitalized for acute neurological deterioration should defer elective genetic testing until stabilized.
- Exclusion: Genetic testing is not a substitute for urgent EEG or neuroimaging.
- Emergency Red Flag: If the patient develops respiratory arrest, prolonged stiffening, or status epilepticus, call 998 (UAE) immediately. This test does not manage acute crises.
Patient FAQ & Clinical Guidance
1. What is the ARHGEF9 gene test and how does it diagnose hyperekplexia/EIEE8?
This genetic test identifies pathogenic variants in the ARHGEF9 gene that cause hyperekplexia (exaggerated startle) and early infantile epileptic encephalopathy type 8, enabling definitive diagnosis and family counselling. Clinical Action: Positive results should be discussed with a neurologist for tailored anti-epileptic treatment and developmental support plans.
2. How is the sample collected and what preparations are needed?
A certified phlebotomist collects a small blood sample (or a drop via FTA card) at your home; no fasting is required, but a detailed clinical history and family pedigree must be provided during the pre-genetic counselling session. Preparation: Have all relevant medical records and affected family member information ready for the virtual consultation.
3. What legal protections and privacy measures apply to my genetic data in the UAE?
All genetic data is protected under the UAE Personal Data Protection Law (Federal Decree-Law No. 45 of 2021) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Results are disclosed exclusively to the requesting DHA-licensed physician. Your Rights: You may request data deletion after reporting, and the lab never shares data with third parties without explicit consent.
UAE Regulatory & Data Privacy Adherence
DHA Facility License: 1143 | ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
All testing performed in compliance with DHA/MOHAP standards. Your personal data is safeguarded under Federal Decree-Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019. Clinical consent adheres to Federal Decree-Law No. 4 of 2016 on Medical Liability. © DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | ARHGEF9 Gene-Related Hyperekplexia & EIEE8 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) with Copy Number Variant (CNV) Calling |
| ICD-10-CM Code | G25.8, G40.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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