Test Price
2,800 AED✅ Home Collection Available
RELN Gene Lissencephaly Type 2 (Norman‑Roberts Syndrome) Genetic Test in UAE 2800 AED
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This targeted Next‑Generation Sequencing (NGS) test analyzes the full coding region and exon‑intron boundaries of the RELN gene, providing a definitive diagnosis for Norman‑Roberts syndrome—a severe cortical malformation characterized by lissencephaly, cerebellar hypoplasia, and profound neurodevelopmental delay. The test is essential for affected neonates and for families seeking accurate genetic counselling and prenatal risk assessment.
| Feature | Our Test (RELN NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Method | Next‑Generation Sequencing (full gene coverage, including deep intronic regions) | Sanger sequencing (limited to coding exons ±20 bp; may miss non‑canonical variants) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sensitivity | >99.9% for point mutations, small indels, splice‑site variants | ~95% in targeted regions; no copy‑number variation detection |
| Pre‑Test Requirements | Clinical history + genetic counselling pedigree | Often direct‑to‑consumer; no mandatory counselling |
| Price | 2800 AED | 2600–3000 AED (variable) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA: 9294403)
“This genetic test provides a definitive molecular diagnosis for Norman‑Roberts syndrome. However, results must be interpreted in conjunction with clinical findings, imaging, and family history. Genetic counselling is essential for understanding inheritance patterns and reproductive options. Please do not base management decisions solely on this report—consult a clinical geneticist.”
Medication Advisory
Patients should not alter or stop any current medications without explicit instruction from their treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Sample collected without a completed clinical history form and signed genetic counselling consent.
- Exclusion: Inadequate sample (haemolysed blood, insufficient DNA on FTA card) – recollection will be requested.
- Emergency: If the child experiences acute neurological deterioration, uncontrolled seizures, or respiratory distress, seek emergency care immediately.
- Emergency: Do not delay urgent medical management while awaiting genetic test results.
Patient FAQ & Clinical Guidance
1. What is the RELN gene lissencephaly type 2 test and who should consider it?
Snippet Answer: This NGS‑based genetic test detects pathogenic variants in the RELN gene associated with Norman‑Roberts syndrome, a severe brain malformation, recommended for neonates with lissencephaly or families with a known history.
The test is indicated for newborns presenting with profound hypotonia, microcephaly, and characteristic MRI findings of lissencephaly and cerebellar hypoplasia. It is also crucial for at‑risk families seeking preconception or prenatal planning, as the disorder follows autosomal recessive inheritance. A mandatory genetic counseling session will help interpret results and guide reproductive options.
2. How accurate is this genetic test and what is the turnaround time in the UAE?
Snippet Answer: With >99.9% analytical sensitivity, our ISO‑certified sequencing identifies all mutation types and delivers results in 3 to 4 weeks.
The NGS workflow is performed in an ISO 9001:2015 facility, ensuring robust coverage of the entire RELN coding region. Sanger confirmation of detected variants and rigorous bioinformatic pipelines guarantee clinical‑grade accuracy. The turnaround time of 3–4 weeks includes DNA extraction, library preparation, sequencing, data analysis, and a comprehensive medical report.
3. Is home sample collection available across all Emirates, and how do I prepare?
Snippet Answer: Yes, our VIP phlebotomy service covers Dubai, Abu Dhabi, Sharjah, and all Northern Emirates, requiring only a clinical history form and a genetic counseling session beforehand.
Our certified mobile team reaches every emirate daily until 11 PM. Before collection, please ensure the patient’s clinical history and signed genetic counselling consent are provided; a family pedigree chart must be drawn. Samples accepted: whole blood (EDTA), extracted DNA, or a single blood drop on an FTA card. All samples are transported under validated cold‑chain conditions to preserve DNA integrity.
UAE Regulatory & Data Privacy Adherence
At DNA Labs UAE, we adhere to the highest standards of data protection and patient privacy as mandated by UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA facility license number 1143 and premises at Dubai Healthcare City ensure full compliance with local regulations.
Clinical & Logistical Metadata
| Test Name | RELN Gene Lissencephaly Type 2 (Norman‑Roberts Syndrome) Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage including Intronic Regions |
| ICD-10-CM Code | Q04.3 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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