Test Price
2,800 AEDโ Home Collection Available
DDHD2 Gene SPG54 Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Genetic Counseling by a Consultant Medical Geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This advanced genetic test delivers precise diagnosis of DDHD2 gene mutations causing hereditary spastic paraplegia type 54 (SPG54) through next-generation sequencing technology operating under ISO quality standards. Service includes premium home phlebotomy, a DHA-certified medical report, and post-result specialist consultation.
Test Overview & Methodology
A high-precision genetic test that sequences the entire DDHD2 gene to diagnose hereditary spastic paraplegia type 54 (SPG54), a rare progressive neurological disorder characterized by lower-limb spasticity and weakness. Targeted next-generation sequencing provides comprehensive coverage of all coding exons and splice sites to identify pathogenic single nucleotide variants and small insertions or deletions.
| Feature | Our DDHD2 SPG54 NGS Test | Conventional Sequencing |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) with full gene coverage | Sanger sequencing of select exons only |
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | >95% but limited to targeted regions |
| Turnaround Time | 3 to 4 weeks with digital report | 6 to 8 weeks |
Physician Insight & Safety Protocols
โThis DDHD2 gene test offers a definitive molecular diagnosis for families confronting progressive spastic paraplegia. A negative result does not eliminate other genetic or acquired causes of spastic paraplegia; therefore, careful clinical correlation with neuroimaging and electrophysiological studies remains indispensable. All findings must be interpreted within the context of a complete neurological workup, and therapeutic adjustments should never be undertaken without specialist consultation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory โ Medication & Management Caution
โ ๏ธ Important Clinical Reminder
Do not discontinue any prescribed antispastic or neuroprotective medication without direct guidance from your treating physician. Genetic test results serve as a supplementary diagnostic resource and do not replace clinical judgment or ongoing therapeutic monitoring.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to obtain informed consent from a legal guardian for minors; patients with known mosaicism may require tissue-specific analysis.
- Emergency Red Flags: Development of acute paraplegia, seizures, vision loss, dysphagia, or respiratory distress โ visit the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the role of this genetic test in confirming SPG54?
Yes, next-generation sequencing of the DDHD2 gene provides definitive genetic confirmation of hereditary spastic paraplegia type 54 in symptomatic individuals. The test identifies pathogenic variants responsible for the disease, enabling accurate family counseling and prognosis estimation.
2. How is the sample collected for this genetic analysis?
Our certified phlebotomist performs a painless home blood draw using standard venipuncture or a simple finger-prick dried blood spot card. Sample collection is available from 8 AM to 11 PM across all emirates, ensuring minimal disruption to your daily routine.
3. What is the turnaround time and who interprets the results?
Results are reported within 3 to 4 weeks and are interpreted by a consultant medical geneticist during a telephonic post-test consultation. The report includes variant classification, clinical significance, and personalized management recommendations.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework: This test operates under the governance of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere strictly to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted and handled in accordance with UAE health data protection standards.
Laboratory Credentials: DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE โ ISO 9001:2015 Certified.
Clinical & Logistical Metadata
| Test Name | DDHD2 Gene SPG54 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 94244-1 |
| DHA Facility License & Laboratory Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians