Test Price
2,800 AED✅ Home Collection Available
TRPM7 Gene Susceptibility Test for ALS‑Parkinsonism/Dementia Complex in UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015‑Accredited NGS Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Daily 8 AM–11 PM).
Clinical Guidance: Complimentary Telephonic Post‑Test Clinical Correlation with a DHA‑Licensed Consultant Medical Geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) test detects pathogenic variants in the TRPM7 gene associated with autosomal dominant susceptibility to the ALS‑parkinsonism/dementia complex, enabling early risk stratification, family planning, and neurologist‑guided preventive interventions. The test employs Illumina NovaSeq X Plus technology with LC‑MS/MS validation for full coding region coverage.
| Feature | Our Test (NGS, ISO Certified) | Closest Alternative (Single‑Gene PCR) |
|---|---|---|
| Precision | 99.9% analytical sensitivity, full coding region coverage | Limited to targeted mutations only |
| Methodology | Illumina NovaSeq X Plus, LC‑MS/MS‑validated | PCR with Sanger verification |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist with DHA Registration ID 9294403, I emphasize that a pathogenic TRPM7 variant indicates increased lifetime susceptibility—not a confirmed clinical diagnosis. Result interpretation must incorporate full neurological examination, family pedigree analysis, and multidisciplinary specialist input. Predictive genetic testing should never replace standard clinical surveillance or emergency care.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics
Safety Advisory
Exclusion Criteria & Urgent Care Guidance
- This test is not intended for individuals in acute psychiatric crisis or those unable to provide informed consent for genetic testing.
- For minors (under 18 years), parental or guardian consent plus a court order is required for predictive genetic assessment in compliance with UAE regulations.
- If you experience sudden onset weakness, speech difficulty, or severe confusion, seek immediate emergency care by calling 998—these symptoms require urgent medical attention independent of any scheduled blood draw.
Medication Advisory
Important: Do not discontinue any prescribed medication without consulting your treating physician. This genetic test provides risk information and does not replace clinical management or treatment decisions.
Patient FAQ & Clinical Guidance
1. What does a positive TRPM7 variant mean for my risk of ALS‑parkinsonism/dementia?
A positive result identifies a pathogenic or likely pathogenic variant that increases lifetime risk, but penetrance is incomplete; clinical correlation with a DHA‑licensed neurologist is essential for personalized surveillance.
2. How is the sample collected, and is home service available in the UAE?
We offer VIP home phlebotomy across all emirates (8 AM–11 PM) using ISO‑certified cold‑chain logistics; simply provide 4 mL of whole blood in an EDTA tube, or a single drop on an FTA card.
3. Is the test DHA‑licensed and accredited?
Yes, our laboratory holds DHA Facility License Number 1143 and is ISO 9001:2015 accredited, with all genetic analyses performed under DHA regulatory oversight.
4. How long does it take to receive results, and how will they be reported?
Turnaround time is 3–4 weeks from sample receipt. Results are delivered electronically with a detailed clinical interpretation report that includes variant classification per ACMG guidelines.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the processing of genetic and health data.
- Federal Law No. 2 of 2019 – Concerning the Use of Information and Communication Technology in Health Fields, ensuring secure digital health information exchange.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing clinical safety standards and patient consent requirements for diagnostic procedures.
All genetic testing is performed under the oversight of the Dubai Health Authority (DHA), with strict adherence to informed consent protocols and patient data confidentiality.
Clinical & Logistical Metadata
| Test Name | TRPM7 Gene Susceptibility Test for ALS‑Parkinsonism/Dementia Complex |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA tube) or FTA Card (Dried Blood Spot) |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq X Plus) with LC‑MS/MS Validation |
| ICD-10-CM Code | Z15.89 (Genetic susceptibility to other disease) |
| LOINC Code | 21636-5 (Gene mutations identified in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Lab Address | License No. 1143 · Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE · DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians