Test Price
2,800 AED✅ Home Collection Available
SPG21 Gene Genetic Test (NGS) in Dubai – 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by a DHA-licensed expert.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The SPG21 NGS test utilizes next-generation sequencing to analyze the entire coding region of the SPG21 gene, identifying pathogenic mutations linked to Autosomal Recessive Spastic Paraplegia type 21. This comprehensive assay provides definitive molecular diagnosis, aids in genetic counseling, and informs prognosis for patients and their families.
| Feature | Our SPG21 NGS Test | Conventional Sanger Sequencing |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with 100% exon coverage | Single‑gene Sanger sequencing |
| Detection Rate | 99.9% pathogenic variant detection | ~95% (limited to dominant mutations) |
| Turnaround Time | 3–4 Weeks | 8–12 Weeks |
| Price (AED) | 2800 | 3500 |
Physician Insight & Safety Protocols
“Genetic testing for SPG21 must be interpreted together with a detailed family history and clinical examination. While NGS provides high detection rates, a positive result should be followed by genetic counseling to understand recurrence risks and implications for relatives. This test is not a substitute for emergency neurological evaluation in acute presentations.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License: 9294403
Advisory & Safety Precautions
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. This test does not assess drug metabolism or interactions.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals unable to provide a blood or DNA sample due to severe anemia, skin infection at the phlebotomy site, or absence of a legally authorized representative for minors (in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Emergency Red Flags: Seek immediate medical attention if you experience excessive bleeding, hematoma, or signs of infection (redness, swelling, pus) at the collection site. This test is not a substitute for urgent neurological assessment in case of acute weakness, vision loss, or speech difficulty.
Patient FAQ & Clinical Guidance
1. What is the SPG21 gene test, and how does it work?
The SPG21 Genetic Test detects pathogenic variants in the SPG21 gene responsible for spastic paraplegia type 21. Using next-generation sequencing, the test reads the entire coding sequence of the SPG21 gene from your blood or extracted DNA. The results are analyzed against international genetic databases and classified according to ACMG guidelines to determine if disease-causing mutations are present.
2. Who should consider this genetic test?
Individuals with progressive lower limb spasticity, gait disturbance, or a family history of autosomal recessive spastic paraplegia should consider testing. This includes adults experiencing unexplained stiffness and weakness in the legs, children with early-onset motor delay, and asymptomatic carriers who want to assess their reproductive risks. A pre‑genetic counselling session is mandatory to review your pedigree chart and ensure you meet clinical criteria.
3. What is included in the 2800 AED price?
The 2800 AED package includes DNA extraction, NGS sequencing, bioinformatics analysis, and a signed clinical report. You also receive complimentary access to a genetic counselling session for result interpretation, plus secure electronic delivery of your report. Home blood collection within Dubai/Abu Dhabi is available with the VIP mobile phlebotomy service; please confirm availability via WhatsApp.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance
This test operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient genetic data is encrypted, stored securely, and processed with explicit consent. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | SPG21 Gene Genetic Test (NGS) |
| Price (AED) | 2800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood (VIP Mobile Phlebotomy available) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 81247-9 |
| DHA Facility License & Lab Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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