Test Price
2,800 AED✅ Home Collection Available
LRRK2 Gene (PARK8) Parkinson Disease Genetic Test in UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: Temperature-Controlled Cold-Chain Home Collection and VIP Mobile Phlebotomy available daily from 8 AM to 11 PM. Clinical Guidance: Telephonic Post-Test Genetic Counseling included in result interpretation. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. Test Price: 2,800 AED with comprehensive NGS analysis and written report.
Test Overview & Methodology
The LRRK2 Gene (PARK8) Parkinson Disease Genetic Test utilizes Next Generation Sequencing (NGS) to detect pathogenic mutations linked to inherited Parkinson's disease with superior accuracy and depth. This test analyzes the entire coding region of the LRRK2 gene, including splice sites and flanking intronic regions, to identify point mutations, small insertions, deletions, and copy number variations associated with autosomal dominant Parkinson disease type 8.
Comparative Advantage
| Feature | DNA Labs UAE – LRRK2 NGS Test | Standard PCR / Sanger Method |
|---|---|---|
| Diagnostic Sensitivity | 99.9% with full gene coverage | Limited to common founder mutations only |
| Mutation Detection Scope | SNVs, indels, CNVs, splice variants | Targeted hotspot regions only |
| Turnaround Time | 3 to 4 Weeks (comprehensive analysis) | 1 to 2 Weeks (incomplete coverage) |
| Genetic Counseling | Pre- and Post-Test Counseling Included | Not included |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"Genetic testing for the LRRK2 gene provides valuable insight into hereditary risk for Parkinson disease and may guide clinical management, family planning, and eligibility for targeted therapies. However, a positive result does not guarantee disease onset; clinical correlation with neurological evaluation remains essential. Patients should discuss all findings with a qualified neurologist and genetic counselor before making any medical or lifestyle decisions. Our laboratory follows stringent quality control protocols to ensure accurate, reproducible results."
Important Safety Advisory
Do Not Discontinue Prescribed Medication Without Medical Consultation
Genetic test results must be interpreted by a qualified specialist to avoid unnecessary anxiety or misinterpretation. A positive LRRK2 mutation indicates increased susceptibility, not a guaranteed diagnosis. Always correlate genetic findings with complete neurological assessment and family history before drawing clinical conclusions.
Exclusion Criteria & Red Flags
Exclusion Criteria for Testing
- Minors under 18 years without parental consent and explicit guardian authorization as per UAE regulatory frameworks
- Individuals unable to provide informed consent due to cognitive impairment or legal incapacity
- Acute neurological crisis requiring immediate emergency medical intervention
Emergency Red Flags
Sudden onset of severe tremor, loss of balance, confusion, hallucinations, or signs suggestive of neuroleptic malignant syndrome. Seek emergency care immediately if these symptoms arise.
Patient FAQ & Clinical Guidance
1. What is the LRRK2 gene test and why is it performed?
The LRRK2 Genetic Test identifies inherited mutations in the LRRK2 gene that are strongly associated with autosomal dominant Parkinson disease type 8 (PARK8). This test is recommended for individuals with a confirmed family history of Parkinson disease, early-onset symptoms before age 50, or specific ethnic backgrounds with higher founder mutation prevalence. Results help neurologists confirm diagnosis, assess hereditary risk for family members, and guide personalized management strategies.
2. How is the test sample collected and what is the expected turnaround time?
A standard peripheral whole blood sample is collected via our VIP Mobile Phlebotomy service, available daily from 8 AM to 11 PM across Dubai and the Northern Emirates. Our ISO-certified medical couriers maintain strict temperature-controlled cold-chain transport to preserve genomic DNA integrity. The turnaround time is 3 to 4 weeks, which includes NGS library preparation, deep sequencing, bioinformatics variant annotation, and expert medical genetics review. A mandatory pre-test genetic counseling session is arranged prior to sample collection.
3. Is this test covered by insurance and how do I verify my coverage?
Many UAE health insurance plans cover genetic testing when deemed medically necessary by a neurologist or geneticist. Send a clear copy of your insurance card via WhatsApp to +971 54 548 8731 and our billing team will confirm coverage eligibility within 2 hours. We handle direct billing and pre-approval documentation with your insurer. Flexible self-pay options and installment plans are also available for patients without coverage.
4. Can a positive LRRK2 result guarantee I will develop Parkinson disease?
No. A pathogenic LRRK2 mutation indicates increased lifetime risk, but penetrance is incomplete and age-dependent. Many individuals carrying a mutation never develop clinical symptoms. Environmental factors, epigenetic modifiers, and additional genetic modifiers all influence disease expression. Our genetic counseling session explains these concepts thoroughly and provides risk stratification based on current medical literature.
UAE Regulatory & Data Privacy Adherence
Legal Compliance Framework
This genetic test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) governing the collection, processing, and storage of genetic data. All clinical testing adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure digital health records. Patient safety and informed consent protocols strictly follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
DNA Labs UAE operates under DHA Facility License Number 1143 with ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) for quality management systems. All genetic data remains confidential, encrypted, and accessible only to the ordering physician and the patient.
Clinical & Logistical Metadata
| Test Name | LRRK2 Gene (PARK8) Parkinson Disease Genetic Test – Next Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube); alternative: extracted genomic DNA (≥1 µg, ≥50 ng/µL) |
| Methodology Used | Next Generation Sequencing (NGS) – Whole gene coding region, splice sites, and flanking intronic regions; minimum 100x mean depth |
| ICD-10-CM Code | G20 (Parkinson disease), Z13.81 (Encounter for genetic testing for disease predisposition) |
| LOINC Code | 95540-2 (Parkinson disease associated gene mutation analysis [LRRK2] in blood by NGS) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians