Test Price
2,800 AED✅ Home Collection Available
ITM2B Gene (Familial British Dementia) Genetic Test in UAE | 2800 AED | DHA Accredited
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This genetic test sequences the entire coding region of the ITM2B gene using next‑generation sequencing (NGS) to detect pathogenic variants causing familial British dementia (FBD), a rare autosomal dominant cerebral amyloid angiopathy. Early molecular diagnosis enables targeted neurological surveillance, family risk assessment, and access to emerging disease‑modifying strategies.
| Feature | Our Test (ISO 9001:2015 Lab) | Closest Alternative |
|---|---|---|
| Methodology | NGS full gene sequencing & copy number analysis | Sanger sequencing of selected exons / research‑grade panels |
| Diagnostic Precision | >99.9% sensitivity for single nucleotide variants & indels | ~95% sensitivity, may miss deep intronic or regulatory variants |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks (variable) |
| Regulatory Status | DHA‑licensed, ISO 9001:2015, UAE PDPL compliant | Often non‑accredited or research only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403) emphasizes: “This genetic test provides definitive molecular evidence for familial British dementia when a pathogenic ITM2B variant is identified. However, results must always be interpreted within the complete clinical context, including neurological examination and family pedigree analysis. A positive result confirms genetic predisposition but does not predict age of onset or symptom severity. I strongly recommend pre‑ and post‑test genetic counseling to address psychological, familial, and medical implications.”
Advisory Notes
Important Clinical Advisory:
Genetic results from this test provide diagnostic and predictive information but do not replace ongoing clinical management. Do not discontinue or adjust any prescribed medication or therapy based solely on genetic findings. All treatment decisions must be made by your treating physician following comprehensive clinical evaluation.
Exclusion Criteria & Emergency Red Flags
- Asymptomatic minors under 18 years: Testing governed by UAE regulations — court approval and guardian consent required.
- Acute medical crisis: Individuals with rapid cognitive decline, seizures, or stroke‑like symptoms must seek emergency care. This test is for outpatient genetic risk assessment only.
- Emergency Red Flags: Sudden confusion, vision loss, focal weakness, or loss of consciousness — call 998 immediately.
Patient FAQ & Clinical Guidance
1. What is the ITM2B gene and familial British dementia?
The ITM2B gene encodes the BRI2 protein. Pathogenic mutations in this gene cause familial British dementia, a rare autosomal dominant cerebral amyloid angiopathy that leads to progressive cognitive decline, ataxia, and spasticity, typically manifesting in the fifth decade of life.
2. How is the test performed and what sample is needed?
A simple blood draw or buccal swab is collected at your home by our DHA‑licensed phlebotomist through our VIP Mobile Phlebotomy service. No fasting or special preparation is required. Extracted DNA is analyzed by high‑sensitivity NGS with full quality metrics.
3. What do the results mean and will my insurance cover it?
A positive report identifies a known disease‑causing ITM2B mutation, confirming the diagnosis or predicting future risk. A negative result significantly reduces the likelihood of FBD but does not exclude all neurodegenerative conditions. We provide direct billing verification with all major UAE insurers via WhatsApp at +971 54 548 8731 before the test is performed.
4. What is the turnaround time for results?
Results are typically available within 3 to 4 weeks from sample collection. This allows for comprehensive sequencing, bioinformatic analysis, and clinical validation of any identified variants.
5. Is genetic counseling provided with this test?
Yes, we offer telephonic post‑test clinical guidance to help interpret your results. We strongly recommend both pre‑ and post‑test genetic counseling with a qualified genetics professional to fully understand the implications for you and your family.
UAE Regulatory & Data Privacy Adherence
Legal & Privacy Compliance Framework
This genetic test and all associated data handling procedures comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of personal health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — regulating digital health information systems and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — establishing clinical safety standards and patient consent requirements for diagnostic procedures.
DNA Labs UAE operates under DHA Facility License Number 1143 and is ISO 9001:2015 certified. All genetic data is encrypted, access‑controlled, and retained only as necessary for clinical care and regulatory compliance.
Clinical & Logistical Metadata
| Test Name | ITM2B Gene (Familial British Dementia) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene sequencing & copy number analysis |
| ICD-10-CM Code | G31.09 – Other frontotemporal dementia; E75.58 – Other cerebral amyloid angiopathy |
| LOINC Code | 101423-5 – ITM2B gene mutation analysis in Blood or Tissue by NGS |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians