Test Price
2,800 AED✅ Home Collection Available
DNMT1 Gene Hereditary Sensory Neuropathy Type 1E DNA Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS with Sanger validation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This cutting-edge genetic test employs Next-Generation Sequencing (NGS) to analyze the DNMT1 gene for pathogenic variants linked to Hereditary Sensory Neuropathy Type 1E (HSAN1E), a progressive autosomal dominant disorder causing severe sensory loss and autonomic dysfunction. The test includes Sanger confirmation for all clinically significant variants, ensuring >99.9% diagnostic sensitivity.
| Parameter | Our Test (DNA Labs UAE) | Closest Alternative (Standard Genetic Panel) |
|---|---|---|
| Precision | 99.9% sensitivity/Sanger validation | ~95% without confirmatory testing |
| Methodology | High-coverage NGS + Sanger confirmation | Targeted genotyping arrays |
| Turnaround Time | 3–4 Weeks (express available) | 6–8 Weeks |
| Cost (AED) | 2800 | 2200–3600 |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I emphasize that this DNMT1 gene test provides a definitive molecular diagnosis for Hereditary Sensory Neuropathy Type 1E. The high sensitivity and confirmatory Sanger sequencing reduce false‐positive and false‐negative rates. However, results must be interpreted in the context of a complete neurological examination and family history. A negative result does not exclude other hereditary neuropathies, and genetic counselling is essential before and after testing."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA License: 9294403)
Patient Advisory
⚠️ Important Medication Notice
Do not discontinue or adjust any prescribed medication based on genetic test results without consulting your treating physician. Genetic findings are a diagnostic aid, not a substitute for ongoing clinical management.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (or legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability, for minors).
- Red Flag: Sudden, rapidly progressive sensory loss with autonomic instability — seek emergency medical evaluation immediately.
- Red Flag: New-onset severe neuropathic pain or unexplained falls — do not attribute solely to known neuropathy without urgent assessment.
Patient FAQ & Clinical Guidance
1. What does a DNMT1 gene test diagnose?
A DNMT1 gene test diagnoses hereditary sensory neuropathy type 1E (HSAN1E), a progressive autosomal dominant disorder causing severe sensory loss and autonomic dysfunction. It detects mutations in the DNMT1 gene that lead to misfolded proteins, affecting peripheral nerves. The test helps confirm clinical suspicion, guide surveillance for associated complications (e.g., hearing loss, dementia), and inform family planning.
2. How is the sample collected and is home collection available?
A small blood sample or a single drop of blood on an FTA card is collected via VIP mobile phlebotomy at your home, office, or hotel across all UAE Emirates. Our DHA‑licensed phlebotomists use ISO‑certified cold‑chain transport, ensuring specimen integrity from your door to our laboratory.
3. What is the turnaround time and how will I receive my results?
Results are delivered within 3 to 4 weeks via a secure, encrypted email link and explained during a telephonic consultation with our DHA physicians. Urgent preliminary reports can be expedited upon request, and we coordinate directly with your neurologist for integrated care.
4. Will my insurance cover the cost of this genetic test?
Coverage depends on your insurance plan and medical necessity as determined by your referring specialist. We can verify your direct billing eligibility by contacting our team via WhatsApp +971 54 548 8731 before testing.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance
DNA Labs UAE operates under DHA Facility License Number 1143 and fully complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the confidentiality and security of your genetic and health information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensuring secure electronic health data handling.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – covering patient consent, privacy, and clinical safety during genetic testing.
All test results are transmitted via encrypted channels. You retain full rights to access, correct, and request deletion of your data under PDPL.
Clinical & Logistical Metadata
| Test Name | DNMT1 Gene Sequencing for Hereditary Sensory Neuropathy Type 1E (HSAN1E) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (express available on request) |
| Sample Type / Matrix | Whole Blood (Peripheral) or FTA Card Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | G60.8 |
| LOINC Code | 21618-3 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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