Test Price
2,800 AEDโ Home Collection Available
ARFGEF2 Gene Periventricular Heterotopia with Microcephaly Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- โ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- โ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM โ 11 PM).
- โ Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation by DHA-licensed specialists.
- โ Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This comprehensive Genetic Test analyzes the entire coding region of the ARFGEF2 gene to detect pathogenic variants linked to periventricular nodular heterotopia with microcephaly, a congenital brain malformation often presenting with epilepsy. This test is essential for precise molecular diagnosis and guiding neurological management.
| Feature | Our ARFGEF2 NGS Test | Conventional MRI + Clinical Assessment |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity for ARFGEF2 point mutations, small indels | Detects structural malformation but cannot identify genetic cause |
| Methodology | Next Generation Sequencing (NGS) with Sanger confirmation | Brain MRI, clinical phenotype scoring |
| Turnaround Time | 3-4 Weeks | Immediate โ few days for MRI report; no genetic confirmatory timeline |
| Actionable Outcomes | Enables family planning, targeted antiepileptic therapy, and risk stratification | Limited to anatomical description |
Pre-Test Requirements
- Clinical History: Detailed neurological and developmental history of the patient.
- Genetic Counselling: Mandatory pre-test genetic counselling session to draw a pedigree chart of family members affected by periventricular heterotopia or microcephaly.
- Sample Types Accepted: Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card).
- Regulatory Note: For minors, prior consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) is mandatory.
Physician Insight & Safety Protocols
"As a medical geneticist, I have witnessed how a confirmed genetic diagnosis brings clarity to families navigating the challenges of periventricular heterotopia and microcephaly. Identifying an ARFGEF2 mutation allows us to tailor antiepileptic therapy and offer precise reproductive counselling. I urge that all results be interpreted in conjunction with a clinical geneticist and never in isolation."
โ Lina Osama Zaki Quteineh, DHA Licensed Consultant Medical Genetics (No. 9294403)
Safety Advisory: Medication Warning
Do not modify prescribed antiepileptic medication without consulting your treating physician. Genetic test results should not override clinical judgment or emergency interventions.
Exclusion Criteria & Emergency Red Flags
- Test is contraindicated as a standalone diagnostic; always correlate with neuroimaging and clinical findings.
- If the patient develops sudden worsening of seizures, loss of consciousness, or signs of increased intracranial pressure (severe headache, vomiting, visual changes), seek emergency medical attention immediately.
- Not suitable for individuals who have undergone allogeneic bone marrow transplant (potential donor DNA contamination).
Patient FAQ & Clinical Guidance
1. What is the ARFGEF2 gene test used for?
This test detects mutations in the ARFGEF2 gene linked to periventricular heterotopia and microcephaly, enabling precise neurogenetic diagnosis. The NGS reads the full coding sequence to identify single nucleotide changes, insertions, deletions, and copy number variants. Results guide management by confirming the molecular basis, informing antiepileptic drug choice, and permitting family risk assessment.
2. Is home sample collection available across the UAE?
Yes, we offer VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection throughout Dubai, Abu Dhabi, Sharjah, and all emirates from 8 AM to 11 PM daily. A trained DHA-licensed phlebotomist will visit your home or office. The sample (blood or FTA card) is transported in medical courier boxes following strict PDPL data privacy protocols. Our service is fully integrated with direct billing and WhatsApp support at +971 54 548 8731.
3. How is my genetic data protected under UAE law?
Your genetic data is safeguarded by Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All information is stored on secure, encrypted servers physically hosted in the UAE. Access is limited to your designated healthcare provider and never shared without explicit consent. Our laboratory operates under DHA Facility License No. 1143, ensuring every step aligns with latest UAE health data privacy regulations.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This genetic test is performed at DNA Labs UAE, a facility licensed by the Dubai Health Authority (License No. 1143). We fully comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient genetic data. Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). Patient consent and safety adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All test results are delivered with strict confidentiality and encrypted electronic reporting.
Clinical & Logistical Metadata
| Attribute | Details |
|---|---|
| Test Name | ARFGEF2 Gene Periventricular Heterotopia with Microcephaly Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q04.8, Q02 |
| LOINC Code | 73732-6 |
| DHA Facility License & Laboratory Address Invariants | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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