Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 weeks
ACTN4 Gene (FSGS Type 1) Next-Generation Sequencing Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary telephonic post-test clinical guidance by a DHA-certified Consultant Medical Genetics.
- Insurance Support: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ACTN4 gene test identifies pathogenic variants linked to autosomal dominant focal segmental glomerulosclerosis type 1 (FSGS1), a progressive kidney disorder. This next-generation sequencing (NGS) assay provides comprehensive coverage of the entire coding region and splice sites, enabling precise genetic diagnosis to guide renal surveillance and early treatment decisions.
| Feature | Our Test (ACTN4 NGS) | Closest Alternative (Traditional Sanger / Overseas Lab) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) โ comprehensive coverage of entire coding region & splice sites | Sanger sequencing (single-gene), often incomplete coverage |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks (international shipping delays) |
| Price | 2,800 AED | 3,500+ AED (incl. courier) |
| Regulatory Compliance | DHA/MOHAP, ISO 9001:2015, UAE PDPL | Often lacks local data privacy compliance |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) emphasizes: โA positive ACTN4 mutation indicates an elevated lifelong risk for FSGS, but disease penetrance is incomplete; surveillance with urinalysis and eGFR remains essential. Clinical correlation and family counselling are paramount before any intervention. Genetic results are a piece of the puzzle, not a definitive forecast.โ
Critical Medication Advisory
Do not discontinue or adjust any prescribed medication (including antihypertensives, immunosuppresants, or steroids) without consulting your treating physician. Genetic results alone do not constitute a treatment directive.
Exclusion Criteria & Emergency Red Flags
Sample Collection Denied:
- Active severe infection requiring systemic therapy.
- Known severe bleeding disorder (e.g., haemophilia A with factor level <1%) without haematology clearance.
- Inability to provide informed consent (cognitive impairment and no legal guardian present).
Emergency Red Flags โ Seek Immediate Care:
- Sudden onset flank pain with hematuria (possible renal vein thrombosis).
- Rapidly progressing leg/eyelid swelling (anasarca) or oliguria (<200 mL urine/24h).
- Severe hypertension (>180/120 mmHg) with visual disturbances.
Patient FAQ & Clinical Guidance
1. What does a positive ACTN4 mutation mean for my kidney health?
Snippet: A positive ACTN4 variant confirms a genetic predisposition to focal segmental glomerulosclerosis type 1, requiring lifelong renal monitoring but not necessarily disease onset.
Clinical follow-up includes annual urinalysis, eGFR measurement, and blood pressure control; your nephrologist will interpret the result in the context of your personal and family history.
2. Is this genetic test covered by UAE health insurance?
Snippet: Many UAE insurers partially cover genetic testing for symptomatic individuals with a strong family history; pre-authorization and direct billing verification are facilitated via WhatsApp.
Provide your insurance card copy to +971 54 548 8731 and our team will confirm coverage within 2 working hours. Self-pay packages are also available.
3. How is the sample collected and is it safe for children?
Snippet: The test requires 3โ5 mL of venous blood drawn under standard sterile procedure; it is safe for minors with parental consent under UAE genetic testing regulations.
We provide certified home collection with temperature-controlled chain, and paediatric blood draws are performed using fine needles with a paediatric specialist present.
UAE Regulatory & Data Privacy Adherence
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling. Health information is processed in accordance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds ISO 9001:2015 certification.
Clinical & Logistical Metadata
| Test Name | ACTN4 Gene (FSGS Type 1) Next-Generation Sequencing Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Whole blood (EDTA) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | N04.1, Z15.09 |
| LOINC Code | 21613-5 |
| DHA Facility License & Address | DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
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Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians