Test Price
3,000 AEDโ Home Collection Available
Myeloproliferative Neoplasm with Eosinophilia (MPN-Eo) Test | Molecular FISH & Morphology Panel | DNA Labs UAE
Executive Summary & Core Metrics
โ Diagnostic Accuracy: >99% analytical sensitivity via ISO 9001:2015 accredited Fluorescence In-Situ Hybridization (FISH) and expert bone marrow morphology workflows.
๐ฅ Hospital Extraction Only โ Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
๐ Clinical Guidance: Post-test telephonic consultation to explain results and next steps.
๐ Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
This integrated panel combines automated hematology analysis, expert bone marrow morphology, and FISH to detect clonal rearrangements in PDGFRA, PDGFRB, FGFR1, and JAK2, providing definitive molecular diagnosis for targeted tyrosine kinase inhibitor therapy.
Test Overview & Methodology
The Myeloproliferative Neoplasm with Eosinophilia (MPN-Eo) test integrates automated blood cell analysis, expert bone marrow morphology, and Fluorescence In-Situ Hybridization (FISH) to detect rearrangements involving PDGFRA, PDGFRB, FGFR1, or JAK2 that drive clonal eosinophilia. This comprehensive approach provides a definitive molecular diagnosis that guides targeted therapy with tyrosine kinase inhibitors.
| Feature | Our MPN-Eo Test | Standard CBC + Basic Morphology |
|---|---|---|
| Precision | FISH probes for 4 gene rearrangements with >99% analytical sensitivity | Morphological suspicion only; no molecular confirmation |
| Methodology | Electrical Impedance + Automated Differential + Microscopy + FISH | Manual differential count; no cytogenetic analysis |
| Turnaround Time | 7 working days | 24โ48 hours for CBC only |
Physician Insight & Safety Protocols
โAs a DHA-licensed Consultant Medical Genetics, I understand the complexity that a suspected MPN-Eo diagnosis brings. This integrated panel delivers definitive molecular evidence through FISH analysis; however, every result must be interpreted alongside your full clinical history, physical examination, and bone marrow findings. I emphasize that no single laboratory test can replace a thorough physician evaluation.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
โ ๏ธ Advisory โ Medication Continuation
Do not discontinue any prescribed medication, including corticosteroids, anticoagulants, or tyrosine kinase inhibitors, without explicit instruction from your treating physician. Sudden withdrawal may worsen disease activity or provoke thrombotic events.
๐จ Safety Exclusion Criteria & Emergency Red Flags
- Bone Marrow Biopsy Contraindications: Severe coagulopathy (INR >1.5, platelets <20ร10โน/L), active infection at the sampling site, inability to lie flat due to respiratory distress.
- After-Procedure Alerts: Persistent oozing or hematoma expansion, fever >38.5โฏยฐC within 24 hours, or new-onset severe back pain.
- Patient Responsibility: Immediately report any of these signs to the emergency department or call our support line.
Patient FAQ & Clinical Guidance
1. How does the FISH test confirm MPN with eosinophilia?
FISH analysis directly visualizes gene rearrangements in PDGFRA, PDGFRB, FGFR1, or JAK2 using fluorescent probes, providing a definitive molecular diagnosis that guides targeted therapy. A positive FISH result indicates eligibility for tyrosine kinase inhibitors such as imatinib, which can induce durable remission.
2. Why do I need both a blood sample and a bone marrow biopsy?
Peripheral blood identifies eosinophil counts and circulating blasts, while the bone marrow aspirate and biopsy assess cellularity, fibrosis, and provide the optimal cellular material for FISH testing. This dual-sample approach ensures a complete diagnostic picture and accurate risk stratification.
3. What legal protections apply to my genetic data in the UAE?
Your genetic information is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. These laws mandate strict confidentiality, informed consent, and secure data handling for all genetic and molecular test results.
UAE Regulatory & Data Privacy Adherence
๐๏ธ UAE Regulatory Compliance: This testing service adheres strictly to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
๐ Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). DHA Facility License: 1143.
๐ Support & WhatsApp: +971 54 548 8731
๐ Pre-requisite: A fully completed Chromosome & FISH Analysis Requisition Form (Form 17) is mandatory before sample collection.
Clinical & Logistical Metadata
| Test Name | Myeloproliferative Neoplasm with Eosinophilia (MPN-Eo) โ FISH & Morphology Panel |
| Price (AED) | 3,000 |
| Turnaround Time | 7 working days |
| Sample Type / Matrix | Peripheral Blood & Bone Marrow Aspirate / Biopsy โ Hospital Extraction Only |
| Methodology Used | Electrical Impedance, Automated Differential, Morphology, FISH (PDGFRA, PDGFRB, FGFR1, JAK2) |
| ICD-10-CM Code | D47.2, D72.1 |
| LOINC Code | 48768-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians