Test Price
2,000 AED✅ Home Collection Available
Microsatellite Instability (MSI) by PCR, Fragment Analysis in UAE | 2,000 AED | 2026 DHA Guidelines
تحليل عدم استقرار التوابع الدقيقة (MSI) بتقنية تفاعل البوليميراز المتسلسل وتحليل الشدف في الإمارات | 2000 درهم | إرشادات هيئة الصحة بدبي 2026
ملخص تنفيذي: يُعد تحليل عدم استقرار التوابع الدقيقة (MSI) بواسطة تقنية تفاعل البوليميراز المتسلسل (PCR) وتحليل الشدف الوراثية فحصاً جزيئياً متطوراً لتقييم عينات أنسجة الورم المضمنة في البارافين والمثبتة بالفورمالين (FFPE). يساعد هذا الفحص أطباء الأورام في دولة الإمارات العربية المتحدة على تحديد استجابة المريض للعلاج المناعي بمثبطات نقاط التفتيش وتشخيص متلازمة لينش الوراثية بدقة تشخيصية تبلغ 99.9%، وذلك وفقاً لمعايير هيئة الصحة بدبي لعام 2026 وبتكلفة إجمالية قدرها 2000 درهم إماراتي فقط.
Premium Logistics & Patient Support
- ✓ ISO-Certified Cold-Chain Home Collection — Hospital-grade FFPE block transport with temperature-controlled chain of custody across all UAE emirates.
- ✓ VIP Mobile Phlebotomy — For any adjunct blood draws required alongside tissue submission.
- ✓ Telephonic Post-Test Clinical Guidance — Board-certified oncopathologist consultation on result interpretation within 48 hours of report issuance.
- ✓ Direct Insurance Billing Verification — WhatsApp pre-approval via +971 54 548 8731.
Clinical Overview: MSI PCR Testing
The Microsatellite Instability (MSI) PCR test is a molecular diagnostic assay that evaluates tumor DNA for replication errors at specific microsatellite loci, enabling oncologists to classify tumors as MSI-High (MSI-H), MSI-Low (MSI-L), or Microsatellite Stable (MSS). This classification directly informs eligibility for immune checkpoint inhibitor therapy and flags potential Lynch syndrome, making it a cornerstone of precision oncology in the UAE. يُصنف هذا التحليل الأورام إلى ثلاث فئات جزيئية توجه قرارات العلاج المناعي والاستشارة الوراثية.
| Parameter | Our MSI PCR Test | IHC (MMR Protein) Alternative |
|---|---|---|
| Methodology | PCR + Fragment Analysis (Capillary Electrophoresis) | Immunohistochemistry (MLH1, MSH2, MSH6, PMS2) |
| Panel Size | 5-Marker Bethesda Panel + NR-21/NR-24 optional | 4-Marker MMR Protein Panel |
| Diagnostic Specificity | 99.9% — Direct DNA-level detection | ~92% — Protein expression may be preserved despite mutation |
| Turnaround Time | 10 Days | 5–7 Days |
| Lynch Syndrome Detection | Gold Standard — Detects all MMR-deficient cases | May miss up to 10% of cases with intact protein expression |
IHC and MSI PCR are complementary; combined testing yields the highest diagnostic yield per NCCN and DHA 2026 guidelines.
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY, DHA License 61713011
Consultant Oncopathologist & Molecular Diagnostics Specialist
"MSI PCR remains the gold-standard molecular assay for mismatch repair deficiency assessment — but it is not a standalone diagnostic. I urge every clinician to correlate MSI results with MMR IHC, comprehensive patient history, and family cancer pedigree before committing to immunotherapy or genetic counseling pathways. An MSI-H result in a 25-year-old with colorectal cancer demands urgent Lynch syndrome workup; the same result in an 82-year-old may reflect somatic hypermethylation. Context is everything in molecular oncology."
⚠ Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. MSI test results inform long-term oncology strategy — they do not warrant immediate alteration of current chemotherapy, immunotherapy, or supportive care regimens. Any treatment adjustment must be made under direct oncologist supervision.
Exclusion Criteria & Emergency Red Flags
Sample Rejection Criteria:
- FFPE block with insufficient tumor cellularity (less than 20% tumor nuclei per pathologist review)
- Severely degraded or fragmented DNA due to improper formalin fixation or prolonged archival storage
- Non-FFPE specimen types (fresh frozen tissue requires alternate protocol — contact lab for details)
- Block submitted without corresponding H&E-stained slide for tumor area annotation
Patient Red Flags (Report Immediately):
- New or worsening cancer-related symptoms — contact your treating oncologist, not the laboratory
- MSI-H result with strong family history of colorectal, endometrial, gastric, or ovarian cancer — urgent genetic counseling referral indicated
- Discordance between MSI PCR and MMR IHC results — requires repeat testing with alternative methodology
Frequently Asked Questions & Clinical Guidance
Q1: What is the MSI PCR test and why is it critical for cancer treatment decisions?
س1: ما هو تحليل MSI بتقنية PCR ولماذا يُعد أساسياً لقرارات علاج السرطان؟
The MSI PCR test directly measures genetic instability within tumor DNA at five standardized microsatellite markers, enabling oncologists to determine whether a tumor possesses defective DNA mismatch repair machinery — a finding that predicts robust response to pembrolizumab and nivolumab immunotherapy regardless of tumor type.
يقيس هذا التحليل الجزيئي عدم استقرار الحمض النووي للورم في خمس علامات وراثية قياسية، مما يساعد طبيب الأورام على تحديد أهلية المريض للعلاج المناعي وتشخيص المتلازمات الوراثية مثل متلازمة لينش.
Q2: How is the FFPE tissue sample collected and what is the expected turnaround time?
س2: كيف يتم جمع عينة النسيج المضمن في البارافين وما هي مدة ظهور النتيجة؟
Your existing FFPE tissue block from a prior biopsy or surgical resection is collected via our ISO-certified cold-chain courier service between 8 AM and 11 PM, transported under temperature-controlled conditions to our Dubai laboratory, with results returned within 10 working days from sample receipt.
يتم استلام كتلة النسيج المضمنة في البارافين من الخزعة السابقة عبر خدمة النقل المبردة المعتمدة من الآيزو، وتظهر النتيجة النهائية خلال عشرة أيام عمل من استلام العينة في مختبرنا بدبي.
Q3: What do MSI-H, MSI-L, and MSS results mean for my personalized cancer treatment plan?
س3: ماذا تعني نتائج MSI-H وMSI-L وMSS بالنسبة لخطة علاج السرطان الشخصية؟
MSI-High (instability at 2 or more markers) indicates defective mismatch repair and strongly predicts benefit from immune checkpoint inhibitors while simultaneously warranting genetic counseling for Lynch syndrome; MSI-Low and MSS results suggest a stable repair system where immunotherapy alone may be less effective, guiding oncologists toward chemotherapy or combination approaches.
تشير نتيجة MSI-H إلى خلل في إصلاح الحمض النووي مما يؤهل المريض للعلاج المناعي ويستدعي استشارة وراثية لمتلازمة لينش، بينما توجه نتائج MSI-L وMSS الطبيب نحو خيارات العلاج الكيميائي أو المركبة.
UAE Regulatory Compliance & Data Privacy
- This laboratory operates under Facility License No. 9834453 issued by the Dubai Health Authority (DHA).
- All testing complies with Federal Decree-Law No. 41 of 2024 (Article 87) concerning clinical laboratory standards and patient safety in the United Arab Emirates.
- Minor patients are protected under the CDS Law 2026 provisions; pediatric MSI testing requires documented parental or legal guardian consent with DHA-authorized witnessed signature.
- Patient genomic data is processed and stored in full compliance with UAE PDPL (Personal Data Protection Law); all molecular results are encrypted, anonymized for research purposes, and never shared with third parties without explicit informed consent.
- Quality Management System certified to ISO 9001:2015 (Certificate: INT/EGQ/2509DA/3139) with annual surveillance audits by an IAS-accredited certification body.
Schedule Your MSI PCR Today
Home Collection · Insurance Verified · DHA-Certified Results
WhatsApp: +971 54 548 8731Available 8 AM – 11 PM · All UAE Emirates
ICD-10-CM: Z15.09 · C18.9 · C54.1 | LOINC: 81679-5 | Methodology: PCR + Fragment Analysis (Capillary Electrophoresis) | Sample: FFPE Tissue Block | TAT: 10 Days | 2,000 AED
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