MT-ND2 Gene Mitochondrial Complex I Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed

Executive Summary & Core Metrics

Executive Summary

This advanced genetic test provides precise detection of mutations in the MT-ND2 gene associated with Mitochondrial Complex I Deficiency, with a diagnostic sensitivity of 99.9% performed in a DHA-accredited and ISO 9001:2015 certified molecular diagnostics laboratory. We offer VIP mobile phlebotomy and temperature-controlled cold-chain home collection across all UAE emirates (available daily from 8 AM to 11 PM), followed by telephonic post-test genetic counselling by a DHA-licensed consultant medical geneticist to ensure complete patient understanding and actionable clinical guidance.

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited Processing.

Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM daily).

Clinical Guidance: Telephonic Post-Test Clinical Guidance by DHA-Licensed Consultant Medical Geneticist (Dr. Lina Osama Zaki Quteineh).

Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The MT-ND2 gene Next-Generation Sequencing (NGS) test analyzes the entire coding region of the MT-ND2 gene to detect pathogenic variants causing Mitochondrial Complex I Deficiency, a severe neurometabolic disorder often presenting with developmental delay, seizures, lactic acidosis, and muscle weakness. This targeted genetic test provides a definitive molecular diagnosis for affected individuals and enables accurate carrier screening and family planning.

Feature	Our MT-ND2 NGS Test	Whole Mitochondrial Genome Panel
Target Precision	100% coverage of MT-ND2 exons with deep read depth for heteroplasmy detection	Broad survey; may miss low-level heteroplasmy in MT-ND2
Methodology	Next-Generation Sequencing (NGS) with custom capture	NGS, but uniform coverage across all mitochondrial genes
Turnaround Time	3–4 weeks	4–6 weeks
Clinical Reporting	Variant interpretation based on ACMG guidelines, personalised with clinical correlation	Broad report; may require secondary confirmation

Physician Insight & Safety Protocols

“As a clinical geneticist, I emphasise the importance of integrating genetic test results with clinical history and family pedigree. A positive MT-ND2 variant confirms the molecular basis of mitochondrial complex I deficiency, but a negative result does not rule out other mitochondrial disorders. Pre- and post-test genetic counseling is essential to ensure accurate interpretation and to guide management decisions.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403

Advisory Note: Medication and Ongoing Care

⚠️ Important Medication Advisory

Do not discontinue any prescribed medication, vitamin, or supplement without consulting your treating physician. Genetic testing provides diagnostic information but is not a substitute for comprehensive neurological care and ongoing clinical management.

Safety Exclusion Criteria & Emergency Indicators

This test is not appropriate for acute medical emergencies. If the patient exhibits seizures, loss of consciousness, or rapid neurological deterioration, seek emergency care immediately.
Genetic testing for minors requires written consent from a legal guardian in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and UAE personal status laws.
This test must not be used as a standalone diagnostic tool for life-threatening metabolic crises; clinical evaluation remains paramount.
If the patient has a bleeding disorder or is on anticoagulants, inform the phlebotomist before sample collection to ensure safe venipuncture.

Patient FAQ & Clinical Guidance

1. What is the MT-ND2 gene test, and why is it performed?

The MT-ND2 gene test is a targeted genetic diagnostic tool that sequences the entire MT-ND2 gene to identify mutations responsible for Mitochondrial Complex I Deficiency. This condition is a severe neurometabolic disorder that often presents in infancy or early childhood with symptoms such as developmental delay, muscle weakness, seizures, and lactic acidosis. The test is ordered when a mitochondrial disorder is suspected based on clinical features and biochemical findings.

2. How is the sample collected, and is home collection available?

A small blood sample (3–5 mL in an EDTA tube) or an FTA card spot is collected by a trained phlebotomist. Yes, we provide VIP mobile phlebotomy and temperature-controlled cold-chain home collection across all UAE emirates from 8 AM to 11 PM daily. Alternatively, if you already have extracted DNA stored (e.g., from a previous biopsy), you may submit that sample after approval from the laboratory.

3. What do my test results mean, and how will I receive them?

A positive result indicates a pathogenic variant in MT-ND2, confirming the diagnosis of Mitochondrial Complex I Deficiency. A negative result reduces the likelihood of this specific disorder but does not exclude other mitochondrial or metabolic diseases. Results are delivered via a secure, DHA-compliant report within 3–4 weeks, followed by a telephonic consultation with a licensed consultant medical geneticist (Dr. Lina Osama Zaki Quteineh) to explain the implications and recommend next steps, including family testing if indicated.

4. Are there any pre-test requirements?

Yes, a thorough clinical history and a three-generation pedigree chart are mandatory. Ideally, these are collected during a pre-test genetic counselling session to ensure accurate interpretation and to discuss the potential implications of the results for the patient and their family.

UAE Regulatory & Data Privacy Adherence

This genetic testing service strictly adheres to UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted and processed in compliance with DHA standards. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and holds DHA Facility License No. 1143.

Clinical & Logistical Metadata

Test Name	MT-ND2 Gene Mitochondrial Complex I Deficiency Genetic Test (NGS)
Price (AED)	2,800
Turnaround Time	3–4 weeks
Sample Type / Matrix	Peripheral whole blood (EDTA tube) or FTA card; or extracted DNA (subject to approval)
Methodology Used	Next-Generation Sequencing (NGS) with custom capture and deep coverage
ICD-10-CM Code	E88.49, E88.9
LOINC Code	100204-3
DHA Facility License & Laboratory Address	License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE