Test Price
2,800 AED✅ Home Collection Available
MT-ND6 Gene Sequencing Test for Leigh Syndrome (Mitochondrial Complex I Deficiency) in Dubai, UAE
Executive Summary & Core Metrics
This next-generation sequencing (NGS) test offers 99.9% diagnostic sensitivity for all coding and deep intronic variants in the MT-ND6 gene, the primary genetic cause of Leigh syndrome due to mitochondrial complex I deficiency. The test is performed on peripheral blood or FTA card samples, with a turnaround time of 3–4 weeks.
VIP mobile phlebotomy is available daily from 8 AM to 11 PM via temperature-controlled cold chain. Pre‑test genetic counselling and post‑result teleconsultation are included. Direct insurance eligibility confirmation is provided via WhatsApp at +971 54 548 8731. All services comply with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The MT-ND6 NGS assay uses massively parallel sequencing to interrogate the entire mitochondrial gene, including deep intronic regions. Bioinformatic variant filtering against gnomAD and ClinVar ensures detection of both known pathogenic mutations and novel, rare variants. This test is clinically validated for confirming Leigh syndrome in infants and children presenting with progressive encephalopathy, hypotonia, and developmental regression.
| Feature | Our Test (NGS) | Closest Alternative (Targeted Mutation Analysis) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% for all coding + deep intronic variants | ~85%, misses novel/rare mutations |
| Methodology | Next-Generation Sequencing (NGS) with bioinformatic variant filtering | PCR + Sanger Sequencing (limited to known loci) |
| Turnaround Time | 3–4 weeks (comprehensive analysis) | 2–3 weeks (narrower scope, may require reflex to NGS) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“The MT-ND6 NGS test is a vital confirmatory step when clinical and radiological signs point toward mitochondrial complex I deficiency, yet it must never replace thorough neurological examination and family history. I strongly advise pre- and post-test genetic counselling to help families understand inheritance risks and reproductive options. Please correlate every result with the patient’s evolving phenotype – this gene can manifest with variable severity, and management remains supportive and multidisciplinary.”
Medication Advisory
⚠️ Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic testing does not replace acute medical management.
Exclusion Criteria & Emergency Red Flags
- Patients without a clinical indication or documented neurological/developmental regression suggestive of Leigh syndrome.
- Minors (<18 years) cannot provide independent consent; parental/legal guardian consent is mandatory per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Any individual currently in a suspected metabolic crisis or acute encephalopathy requires urgent hospital evaluation; this test is elective.
- ER Red Flags: New-onset seizures, sudden loss of consciousness, respiratory distress, or rapid neurological deterioration require immediate emergency care – do not delay for test results.
Patient FAQ & Clinical Guidance
1. What does the MT-ND6 NGS test diagnose?
This test detects pathogenic mutations in the MT-ND6 gene, confirming the diagnosis of Leigh syndrome caused by mitochondrial complex I deficiency. It helps clinicians differentiate from other mitochondrial disorders and guide supportive care strategies.
2. Who should consider undergoing this genetic test?
It is recommended for infants and children presenting with progressive encephalopathy, hypotonia, and developmental regression, as well as for family members with a known history of Leigh syndrome for carrier detection. Pre‑test genetic counselling is mandatory.
3. How is the sample collected in the UAE, and what preparation is needed?
Sample collection is performed via standard venipuncture or a simple finger‑prick onto an FTA card. Our VIP mobile phlebotomy service is available daily from 8 AM to 11 PM. No fasting or medication cessation is required, but a genetic counselling session must be completed beforehand.
UAE Regulatory & Data Privacy Adherence
This test is performed in strict compliance with the UAE’s Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on the Use of Information and Communication Technology in Health Fields. Patient data is encrypted and anonymised, and results are shared only with the referring physician and the patient or legal guardian after secure authentication.
Clinical & Logistical Metadata
| Test Name | MT-ND6 Gene Sequencing (NGS) for Leigh Syndrome |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with bioinformatic variant filtering |
| ICD-10-CM Code | G31.81 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians