Test Price
2,800 AED✅ Home Collection Available
MMR Genes Methylation Analysis (NGS Genetic Test) in Dubai, UAE | AED 2800
Executive Summary & Core Metrics
Executive Summary
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS laboratory processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic post-test clinical guidance in result interpretation by DHA-licensed consultant medical geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MMR Genes Methylation Analysis is a next‑generation sequencing (NGS) epigenetic test that identifies abnormal methylation patterns in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2), critical for diagnosing Lynch syndrome and guiding hereditary cancer surveillance. This genome‑wide methylation profiling offers single‑base resolution across all gene promoters, surpassing conventional methylation‑specific PCR methods.
| Feature | Our Test (NGS Methylation) | Closest Alternative (Methylation‑Specific PCR) |
|---|---|---|
| Precision | Single‑base resolution, genome‑wide methylation patterns | Targeted promoter region only, limited CpG sites |
| Methodology | NGS (bisulfite conversion + massive parallel sequencing) | Methylation‑specific PCR (MSP) |
| Turnaround Time | 3–4 Weeks | 7–10 Days (limited loci) |
Physician Insight & Safety Protocols
“This test reveals epigenetic silencing of MMR genes, particularly MLH1 promoter methylation, which can differentiate sporadic from hereditary colorectal cancers. Results must be integrated with family history and immunohistochemistry; a negative methylation test does not rule out Lynch syndrome, and follow‑up germline sequencing may be indicated.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Advisory & Exclusion Criteria
Advisory – Important Precautions
- Do not discontinue prescribed medication without consulting your doctor. Certain drugs (e.g., hypomethylating agents, valproic acid) may alter methylation signatures; inform your physician of all current treatments.
- Emergency Red Flag: If you experience new‑onset rectal bleeding, unexplained weight loss, or persistent abdominal pain, seek immediate oncologic evaluation. Do not wait for test results.
Exclusion Criteria
- Active chemotherapy or recent blood transfusion (within 2 weeks) may affect DNA yield and methylation stability.
- Known bone marrow transplant recipient; donor DNA interference possible.
- Pregnancy – hormonal changes can influence global methylation patterns; postpone test until after delivery unless clinically urgent.
Patient FAQ & Clinical Guidance
1. What is the purpose of the MMR genes methylation test?
Direct answer: This test detects abnormal methylation in DNA mismatch repair genes to help identify Lynch syndrome or sporadic cancers with epigenetic silencing.
2. How should I prepare for the test, and what sample is required?
Direct answer: You can provide a blood sample (one drop on FTA card, whole blood, or extracted DNA) after a genetic counselling session to document your family pedigree. Home collection is available via VIP mobile phlebotomy from 8 AM to 11 PM.
3. How accurate is this NGS methylation test compared to older methods?
Direct answer: Our NGS‑based analysis achieves >99.9% sensitivity and single‑base resolution across all MMR gene promoters, surpassing conventional MSP tests.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical data are processed under strict confidentiality and security standards. Additionally, patient consent and safety measures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MMR Genes Methylation Analysis (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or Dried Blood Spot on FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) with Bisulfite Conversion |
| ICD-10-CM Code | Z15.09 (Genetic susceptibility to other malignant neoplasm), Z13.89 (Encounter for screening for other disorder) |
| LOINC Code | 81247-1 (Mismatch repair gene mutation detection) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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