Test Price
2,800 AED✅ Home Collection Available
MMADHC Gene Methylmalonic Aciduria CblD Type Next-Generation Sequencing (NGS) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next-Generation Sequencing (NGS) at our DHA-licensed facility.
- Premium Logistics: VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all Emirates.
- Clinical Guidance: Complimentary telephonic post-test guidance in result interpretation by a DHA-certified Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 (message for instant pre-approval).
Test Overview & Methodology
The MMADHC gene NGS test detects pathogenic variants causing methylmalonic aciduria and homocystinuria, CblD type—a rare inherited metabolic disorder. This comprehensive DNA analysis screens the entire coding region and splice sites to confirm diagnosis, guide treatment (high-dose vitamin B12, dietary management), and inform family genetic counseling.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | Next-Generation Sequencing (NGS) | Sanger Sequencing |
| Gene Coverage | Full coding region + splice sites | Selected exons only |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Analytical Sensitivity | 99.9% | ~95% (limited to targeted regions) |
| Variant Detection | SNVs, indels, copy number changes | Mostly point mutations |
Physician Insight & Safety Protocols
"Providing clarity for families facing a potential metabolic disorder is a profound responsibility. This NGS-based test offers a detailed molecular window into the MMADHC gene, yet results must always be interpreted within the full clinical context, including biochemical markers and specialist assessment. A negative result does not rule out all metabolic conditions, and a positive finding should prompt structured genetic counseling and a coordinated care plan with a metabolic specialist."
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication and Treatment Guidance
Do not alter, pause, or discontinue any prescribed vitamin or dietary therapy based solely on genetic test results. Management of methylmalonic aciduria requires a multidisciplinary approach combining genetic, metabolic, and nutritional expertise. Always consult your treating physician before making any changes to your treatment regimen.
Exclusion Criteria and Emergency Red Flags
- Exclusion Criteria: Inability to provide a blood or DNA sample; contraindication to venipuncture.
- Emergency Red Flags: In a child with suspected metabolic crisis – sudden onset of lethargy, vomiting, respiratory distress, or seizures – seek immediate emergency care. This test is not a substitute for emergency metabolic management.
Patient FAQ & Clinical Guidance
1. What is the MMADHC gene test used for?
It screens for pathogenic variants in the MMADHC gene causing methylmalonic aciduria and homocystinuria, CblD type, aiding accurate diagnosis and targeted metabolic management.
2. How is the sample collected and how long for results?
Our VIP phlebotomist collects a blood sample or FTA card drop at your home; temperature-controlled cold-chain transport ensures sample integrity, delivering results in 3 to 4 weeks.
3. Is this test covered by UAE health insurance?
Most UAE insurers cover genetic metabolic testing when medically necessary. We verify your policy instantly via WhatsApp at +971 54 548 8731 before proceeding with any billing.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the following UAE federal frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the secure collection, processing, and storage of your genetic and health information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating electronic health data exchange and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing the legal standards for clinical testing safety, informed consent, and patient care accountability.
Our DHA-licensed facility (License No. 1143) adheres to ISO 9001:2015 quality management standards (Cert: INT/EGQ/2509DA/3139) and follows stringent data security protocols for all genetic testing workflows.
Clinical & Logistical Metadata
| Test Name | MMADHC Gene Methylmalonic Aciduria CblD Type Next-Generation Sequencing (NGS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (venous collection) or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full coding region and splice site analysis |
| ICD-10-CM Code | E71.128, Z15.09, E71.120 |
| LOINC Code | 85913-5 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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