Test Price
2,800 AED✅ Home Collection Available
COQ6 Gene Primary Coenzyme Q10 Deficiency Type 6 Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified NGS processing with Sanger confirmation for all pathogenic variants.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. Hospital-grade sterility maintained throughout.
Clinical Guidance: Telephonic post-test interpretation by DHA-licensed Consultant Medical Genetics specialist. Results delivered with a personalized management roadmap.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test employs high-coverage Next-Generation Sequencing (NGS) to analyze the entire coding region and splice-site boundaries of the COQ6 gene. Pathogenic variants in COQ6 cause primary coenzyme Q10 deficiency type 6, a rare autosomal recessive mitochondrial disorder characterised by steroid-resistant nephrotic syndrome, sensorineural hearing loss, and variable neurological involvement. The assay delivers molecular confirmation to guide targeted CoQ10 supplementation, metabolic surveillance, and family cascade screening.
| Feature | Our Test (NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Diagnostic Precision | Targeted COQ6 gene: 99.9% sensitivity | Broad exome: lower depth for COQ6 locus |
| Methodology | High-coverage NGS + Sanger confirmation | Exome capture + NGS |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Price (AED) | 2,800 | 4,500+ |
Physician Insight & Safety Protocols
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"Receiving a genetic diagnosis for a rare mitochondrial disorder can feel overwhelming. This targeted COQ6 test provides the molecular clarity needed to initiate CoQ10 supplementation and tailor long-term metabolic management. I always counsel families that the result must be integrated with renal function, audiometry, and neurological assessment to build a complete clinical picture."
Advisory Notice: Medication Stability
⚠️ Do Not Alter Prescribed Regimens
Do not discontinue, adjust, or initiate any medication—particularly CoQ10 supplements, anticonvulsants, or immunosuppressants—without explicit consultation with your treating physician. Abrupt changes in mitochondrial support therapies can precipitate metabolic decompensation or seizure recurrence.
Exclusion Criteria & Safety Red Flags
Conditions Requiring Rescheduling or Immediate Care
- Active infection or fever exceeding 38.5°C — postpone blood collection until clinically stable.
- Blood transfusion within the preceding 4 weeks may compromise DNA integrity; inform your phlebotomist prior to draw.
- Sudden onset of muscle weakness, seizures, dyspnoea, or altered consciousness requires immediate emergency department evaluation. A genetic test result does not substitute for urgent medical attention.
Patient FAQ & Clinical Guidance
1. What does a positive COQ6 mutation mean for my health?
Short Answer: A positive result confirms a genetic predisposition to primary coenzyme Q10 deficiency type 6, warranting prompt biochemical and neurological evaluation to determine current disease activity.
The finding indicates two pathogenic variants in the COQ6 gene impairing CoQ10 biosynthesis. Clinical severity varies widely; brain MRI, serum lactate, and coenzyme Q10 level assessment are essential next steps under a metabolic specialist. Early diagnosis enables targeted supplementation and proactive monitoring of renal and auditory function.
2. How is the sample collected and what are my options?
Short Answer: Our ISO-certified phlebotomist collects a peripheral whole blood sample via venipuncture under strict cold-chain conditions, processed at our DHA-licensed laboratory within 24 hours.
Alternatively, you may submit a DNA FTA card or previously extracted high-quality genomic DNA. VIP Mobile Phlebotomy at your home or office is available daily from 8 AM to 11 PM, adhering to hospital-grade sterility protocols used by thousands of UAE patients.
3. Will my genetic data remain confidential under UAE law?
Short Answer: Yes. All genetic results are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and encrypted in transit and at rest.
We comply with Federal Law No. 2 of 2019 on health data governance. Your DNA sequence is shared exclusively with the ordering clinician and never disclosed to third parties without your explicit written consent. You have the right to access, rectify, and request deletion of your data at any time.
4. Can this test determine if my children are at risk?
Short Answer: Yes. Confirmatory testing of first-degree relatives is recommended following a positive proband result. Carrier testing for at-risk family members is available.
Primary CoQ10 deficiency type 6 follows autosomal recessive inheritance. Each sibling of an affected individual has a 25% chance of inheriting both variants. Genetic counselling is provided as part of the post-test consultation to discuss recurrence risks, prenatal options, and surveillance planning.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Governance Framework
All genetic data are processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
For result interpretation or home collection booking, contact us via WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | COQ6 Gene Primary Coenzyme Q10 Deficiency Type 6 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL EDTA) or DNA FTA card. VIP Mobile Phlebotomy available daily 8 AM–11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – high-coverage targeted panel with Sanger confirmation of all pathogenic/likely pathogenic variants. |
| ICD-10-CM Code | E63.8 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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