Test Price
2,800 AED✅ Home Collection Available
FGF23 Gene Analysis for Autosomal Dominant Hypophosphatemic Rickets (NGS) in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation by DHA‑licensed Consultant Medical Genetics.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Corporate Oversight: DNA Labs UAE – DHA Facility License No. 1143.
Test Overview & Methodology
The FGF23 Gene NGS Test provides definitive molecular diagnosis of autosomal dominant hypophosphatemic rickets (ADHR) through comprehensive sequencing of the entire FGF23 coding region. This advanced genetic analysis enables precise identification of gain‑of‑function mutations that disrupt phosphate homeostasis, guiding targeted therapy with phosphate supplements, calcitriol, or burosumab. In the UAE, this test is the gold standard for families with a history of childhood rickets, unexplained hypophosphatemia, or metabolic bone disease.
| Feature | Our Test (NGS Full Gene) | Sanger Sequencing (Alternative) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity, covers all exons and splice sites | 99.0% but may miss deep intronic variants |
| Methodology | Next Generation Sequencing (NGS) with confirmatory analysis | Sanger sequencing – single amplicon at a time |
| Turnaround | 3 to 4 weeks | 6 to 8 weeks |
| Variant Detection | SNVs, indels, splice‑site variants with 95% target coverage at 50x | Limited to known hotspot regions |
Physician Insight & Safety Protocols
“Detecting an FGF23 mutation is a pivotal step toward personalised care for hypophosphatemic rickets. While this test is highly specific, every result must be correlated with serum phosphate, FGF23 levels, and skeletal imaging. Our multidisciplinary team guides you through the diagnostic journey without delay—please do not interrupt any current therapy without a full clinical review.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Continuity and Clinical Oversight
Important clinical note
Maintain all prescribed therapies—phosphate supplements, calcitriol, or burosumab—unless your treating physician explicitly advises a change. Abrupt discontinuation can worsen metabolic bone disease and precipitate acute complications.
Exclusion Criteria and Emergency Red Flags
- Blood transfusion within the last 90 days may interfere with DNA extraction and NGS analysis.
- Active dental abscess or acute bone infection requires deferral of sample collection until resolution.
- Seek immediate emergency care for sudden severe bone pain, pathological fracture, or breathing difficulty—do not await test results.
Patient FAQ & Clinical Guidance
1. What is the FGF23 gene test and why do I need it?
This test sequences the FGF23 gene to identify mutations causing autosomal dominant hypophosphatemic rickets (ADHR), a condition leading to weak bones, dental problems, and growth disturbances. It is the gold standard for molecular diagnosis, guiding lifelong management with phosphate and active vitamin D analogues. In the UAE, it is commonly ordered when there is a family history of childhood rickets or unexplained hypophosphatemia.
2. How is the test performed and what sample types are accepted?
A simple blood draw or use of an FTA card (one drop of blood) is all that is required; whole blood, extracted DNA, or dried blood spots are accepted. Our VIP mobile phlebotomy team visits your home between 8 AM and 11 PM, ensuring sample stability via temperature‑controlled cold‑chain transport directly to our ISO‑certified genetics laboratory. Turnaround time is 3 to 4 weeks from sample receipt.
3. Will I receive telephonic guidance with my results?
Yes, every patient receives a scheduled telephonic consultation with a DHA‑licensed Consultant Medical Genetics to interpret the FGF23 result in the context of their complete clinical picture. The consultation includes pedigree review, recommendations for family cascade screening, and integration with the current treatment plan. You may also request a detailed written report for your primary physician.
4. Can this test be used for prenatal diagnosis?
Yes, after confirmation of the familial FGF23 mutation, targeted prenatal testing is available on chorionic villus sampling or amniotic fluid specimens. This requires prior genetic counselling and written informed consent. Please contact our genetics department to coordinate the necessary pre‑test consultations.
UAE Regulatory & Data Privacy Adherence
Compliance and data protection
All genetic data processing, storage, and sharing associated with the FGF23 Gene Analysis adhere to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License No. 1143 and maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | FGF23 Gene Analysis for Autosomal Dominant Hypophosphatemic Rickets (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or dried blood spots (FTA card). VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next Generation Sequencing (NGS) – whole gene sequencing with confirmatory Sanger analysis for clinically significant variants |
| ICD-10-CM Code | E83.31 (Hypophosphatemia, hereditary), E83.30 (Hypophosphatemia, unspecified) |
| LOINC Code | 104933-8 (FGF23 gene targeted mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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