Test Price
2,800 AED✅ Home Collection Available
ALPL Gene Hypophosphatasia (Childhood-Onset) Genetic Test in UAE | AED 2800 | 2026 DHA Guidelines
تحليل جين ALPL لنقص الفوسفاتاز الطفولي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
فحص جيني دقيق لتشخيص نقص الفوسفاتاز الطفولي بتقنية التسلسل الجيني للجيل التالي، بدقة تتجاوز ٩٩.٩%، مع استشارة وراثية شاملة وخدمة سحب منزلي آمن وفق معايير هيئة الصحة بدبي.
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO 9001:2015 accredited NGS platform.
- Home Collection: Hospital-grade VIP phlebotomy service with cold-chain transport (8 AM – 11 PM, all emirates).
- Post-Test Guidance: Complimentary telephonic clinical correlation with a DHA-licensed genetic counsellor.
- Insurance: Direct billing support – quick verification via WhatsApp +971 54 548 8731.
UAE Legal & Regulatory Compliance:
This test adheres to Federal Decree-Law No. 41 of 2024 (Art. 87 on genetic testing safeguards), UAE PDPL (Federal Decree-Law No. 45 of 2021), and the Child Rights Law (Federal Law No. 3 of 2016, as amended) for minors. Facility Licensed No. 9834453.
Clinical Overview & Test Technology
The ALPL gene NGS test detects pathogenic variants in the ALPL gene causing childhood-onset hypophosphatasia, a rare metabolic bone disease. يفحص الاختبار جين ALPL كاملاً لاكتشاف الطفرات المسببة لنقص الفوسفاتاز الطفولي، وهو مرض عظمي استقلابي نادر.
| Parameter | Our NGS Test (ALPL Whole Gene) | Alternative (Sanger Sequencing) |
|---|---|---|
| Technology | Next‑Generation Sequencing (Illumina®) with full bioinformatics pipeline | PCR‑based Sanger sequencing of individual exons |
| Sensitivity | >99.9% for single nucleotide variants, indels, and copy number changes | ~95% in targeted regions; missed deep intronic and large rearrangements |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Regulatory Status | DHA‑licensed lab, ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Often foreign reference labs without local UAE accreditation |
Physician Insight & Safety Protocol
“As a consultant clinical geneticist, I emphasise that ALPL gene testing must be integrated with clinical symptoms, low alkaline phosphatase levels, and radiographic findings. A negative NGS result does not exclude hypophosphatasia; careful paediatric follow‑up remains essential. Always involve a metabolic specialist before making any therapeutic decision.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011, Consultant Clinical Genetics
⚠️ Important: Do not discontinue any prescribed medication (e.g., asfotase alfa) without consulting your treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to provide informed consent, insufficient blood volume, or non‑viable FTA card sample.
- Paediatric Safeguard: For minors, a pre‑test genetic counselling session and legal guardian consent are mandatory as per UAE law.
- Sample Interference: Recent blood transfusion (<2 weeks) or active severe infection (fever >38.5°C) may compromise DNA integrity – reschedule if unsure.
- 🚨 Emergency Red Flags: If the child develops acute chest pain, sudden breathing difficulty, severe bone pain, or pathologic fracture, seek emergency care immediately – this test is not for acute crisis management.
Frequently Asked Questions (Bilingual Clinical Guidance)
Q: How sensitive is this NGS test for hypophosphatasia? / ما مدى حساسية اختبار NGS لنقص الفوسفاتاز؟
This whole‑gene NGS assay achieves 99.9% diagnostic sensitivity for ALPL pathogenic variants, encompassing missense, nonsense, splice‑site, and copy number changes, confirming its role as the definitive molecular standard for hypophosphatasia diagnosis.
الجواب: يحقق اختبار التسلسل الكامل لجين ALPL حساسية تشخيصية تصل إلى 99.9% للطفرات المسببة لنقص الفوسفاتاز الطفولي، مما يجعله المعيار الذهبي للتشخيص الجزيئي.
Q: What sample is required and how is it collected? / ما العينة المطلوبة وكيف يتم جمعها؟
A simple blood draw (3–5 mL EDTA tube) or a single drop on an FTA card is sufficient, and our DHA‑certified mobile phlebotomy team visits your home between 8 AM and 11 PM for a comfortable, cold‑chain compliant collection.
الجواب: يكفي أخذ عينة دم وريدي بسيطة أو قطرة دم واحدة على بطاقة FTA، ويقوم فريقنا المتنقل المعتمد بزيارة منزلية لجمع العينة بطريقة مريحة.
Q: Is genetic counselling included with the test? / هل تشمل الخدمة الاستشارة الوراثية؟
A mandatory pre‑ genetic counselling session is provided to draw the family pedigree and explain inheritance risks, ensuring fully informed consent in line with UAE Federal Decree‑Law No. 41 of 2024.
الجواب: تُقدم جلسة استشارة وراثية قبل الفحص لرسم شجرة العائلة وشرح الآثار، بما يضمن الموافقة المستنيرة وفقاً للقوانين الإماراتية.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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